Protein Alignment RDH8 and CG31937

DIOPT Version :10

• Sequence 1: NP_056540.3
• Gene: RDH8 / 50700
• HGNCID: 14423
• Length: 311
• Species: Homo sapiens
• Sequence 2: NP_608616.2
• Gene: CG31937 / 326177
• FlyBaseID: FBgn0031360
• Length: 321
• Species: Drosophila melanogaster
• Alignment Length: 197
• Identity: 60/197 - (30%)
• Similarity: 97/197 - (49%)
• Gaps: 15/197 - (7%)

Human     6 RTVLISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLG-----KKETLEAAAGEALGQTLTVAQL 65
            :.|.|:|.|||||..||:.||....|   :|.:.|.|.     ::|.|.||.|....:.:.|.|:
  Fly    47 QVVWITGASSGIGRALALSLARHGVK---LVLSARRLEQLEQVQEECLAAARGLLATKDVLVIQM 108

Human    66 DVCSDESVAQCLSCIQG---EVDVLVNNAGMGLVGPLEGLSLAAMQNVFDTNFFGAVRLVKAVLP 127
            |:...:.....|:.:..   .:||||||||.........:.:...:.:|:.:.|..|.|.:.|:.
  Fly   109 DMLDLDEHKTHLNTVLNHFHRLDVLVNNAGRSQRASWTEVEIEVDRELFELDVFAVVHLSRLVVR 173

Human   128 GMKRRR--QGHIVVISSVMGLQGVIFNDVYAASKFALEGFFESLAIQLLQFNIFISLVEPGPVVT 190
            ....:.  :|||...||:.|...|.|:..|.|:|.||..:..||.:::.:.:  :||..|||:.|
  Fly   174 YFVEQNGGRGHIAATSSIAGFSPVPFSPTYCAAKHALNAYLLSLKVEMRKLD--VSLFAPGPIAT 236

Human   191 EF 192
            :|
  Fly   237 DF 238

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RDH8	NP_056540.3	type1_17beta-HSD-like_SDR_c	6..262	CDD:187666	60/197 (30%)
CG31937	NP_608616.2	Rossmann-fold NAD(P)(+)-binding proteins	44..293	CDD:473865	60/197 (30%)