Protein Alignment CAH16 and CA12

DIOPT Version :10

• Sequence 1: NP_001287620.1
• Gene: CAH16 / 50101
• FlyBaseID: FBgn0040628
• Length: 286
• Species: Drosophila melanogaster
• Sequence 2: NP_001209.1
• Gene: CA12 / 771
• HGNCID: 1371
• Length: 354
• Species: Homo sapiens
• Alignment Length: 291
• Identity: 88/291 - (30%)
• Similarity: 141/291 - (48%)
• Gaps: 34/291 - (11%)

  Fly     9 LLLLLPLAFYQST----NGMEWNYLKNGKDWEDLCS------SGKHQSPILLDSRTAR-KWVLPG 62
            :|||:.|....|:    ||.:|.|.  |.|.|:..|      .|..||||.|.|...: ...|..
Human    11 VLLLVILKEQPSSPAPVNGSKWTYF--GPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTP 73

  Fly    63 ITFWHYYRLLKRPFYIRNNGHSISLDIPVTSNGRKPFITGGRLKGRYYADGLHFHWGSYKS-RGS 126
            :.|..|.....:.|.:.|||||:.|::|...:     |.|  |:.||.|..||.|||:... .||
Human    74 LEFQGYNLSANKQFLLTNNGHSVKLNLPSDMH-----IQG--LQSRYSATQLHLHWGNPNDPHGS 131

  Fly   127 EHLINKRRFDAEIHIVHRN-EKYRNIAQAVRQKDGLAVVAIMVAIVRKDNAKSTPLSRLMEAVVR 190
            ||.::.:.|.||:||||.| :.|.:.:.|..:.:||||:|:::.:    .:.:....::...:..
Human   132 EHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEM----GSFNPSYDKIFSHLQH 192

  Fly   191 VPIEDSNATVFGQSSLDQLIGGVSHRDFFTYEGSLTTPLCDETVTWIVFTETTTVTMSSVSKFWL 255
            |..:...|.|.| .::::|:...: .:::.|.||||||.|:.||.|.||.....::...:.....
Human   193 VKYKGQEAFVPG-FNIEELLPERT-AEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALET 255

  Fly   256 ------LRDHWGHRLINNYRIVQDLNNRTVF 280
                  :.|.....:|||:|.||..:.|.|:
Human   256 ALYCTHMDDPSPREMINNFRQVQKFDERLVY 286

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CAH16	NP_001287620.1	Carb_anhydrase	33..281	CDD:459707	78/263 (30%)
CA12	NP_001209.1	alpha_CA_XII_XIV	39..289	CDD:239400	77/261 (30%)