Protein Alignment CAH16 and CA4

DIOPT Version :10

• Sequence 1: NP_001287620.1
• Gene: CAH16 / 50101
• FlyBaseID: FBgn0040628
• Length: 286
• Species: Drosophila melanogaster
• Sequence 2: XP_005257696.1
• Gene: CA4 / 762
• HGNCID: 1375
• Length: 336
• Species: Homo sapiens
• Alignment Length: 316
• Identity: 94/316 - (29%)
• Similarity: 133/316 - (42%)
• Gaps: 59/316 - (18%)

  Fly     9 LLLLLPLAFYQSTNGME--WNYLKNGKD----------WEDLCSSGKHQSPILLDSRTARKWVLP 61
            ||.||.|:..:.:...|  |.|....:.          |...|...: ||||.:.:..|:.....
Human     4 LLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDR-QSPINIVTTKAKVDKKL 67

  Fly    62 GITFWHYYRLLKRPFYIRNNGHSISLDIPVTSNGRKPFITGGRLKGRYYADGLHFHWGSYKSRGS 126
            |..|:..|. .|:.:.::|||||:.:.:.     .|..|:||.|...|.|..||.||.....:||
Human    68 GRFFFSGYD-KKQTWTVQNNGHSVMMLLE-----NKASISGGGLPAPYQAKQLHLHWSDLPYKGS 126

  Fly   127 EHLINKRRFDAEIHIVHRNEK--YRNIAQAVRQKDGLAVVAIMVAI-----------VRKDNAKS 178
            ||.::...|..|:||||..||  .||:.:|...:|.:||:|.:|.|           .|.....|
Human   127 EHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEIGRMNWPPPLAPCRLSQDPS 191

  Fly   179 TPLSR----------LMEAVVRVPIEDSNATVFGQSSLDQLIGGVSHRDFFTYEGSLTTPLCDET 233
            .|...          |:||:..:|..:.:.|:...|.||.|......|.:|.|.||||||.|||.
Human   192 LPFQAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEK 256

  Fly   234 VTWIVFTETTTVTMSSVSKFWLLRDHWGHRLI----------NNYRIVQDLNNRTV 279
            |.|.||.|...:....:..|       ..:|.          :|.|.:|.|..|||
Human   257 VVWTVFREPIQLHREQILAF-------SQKLYYDKEQTVSMKDNVRPLQQLGQRTV 305

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CAH16	NP_001287620.1	Carb_anhydrase	33..281	CDD:459707	86/290 (30%)
CA4	XP_005257696.1	alpha_CA_IV_XV_like	48..307	CDD:239391	84/272 (31%)