DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15864 and p4ha3

DIOPT Version :9

Sequence 1:	NP_652183.2	Gene:	CG15864 / 50001	FlyBaseID:	FBgn0040528	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	XP_021322008.1	Gene:	p4ha3 / 563281	ZFINID:	ZDB-GENE-041010-4	Length:	616	Species:	Danio rerio

Alignment Length:	543	Identity:	141/543 - (25%)
Similarity:	249/543 - (45%)	Gaps:	96/543 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 FVKSNPKKSYA---ASTMELMKLLEVEDELVDNLKGYVKTLKMKFNLMERSLIDMSRENMEMKSD 84
            ::.:.|.:|:.   .|.:.:.:.:..|.:|:|:|..|::....:...::|....::..:..:.::
Zfish    12 YLLNMPDESFGEMFTSMLSVNQAVSAERKLIDHLIIYIEHEAQRLEDIKRFFSRVTSLHDGIYNE 76

  Fly    85 YESYLGNPLNSFRLIHRLHTSWRKWYQYAIKVENNALGHIENARLMRKMLPTSSDLQQACRGIHD 149
            ....:.||:.:|:|:.||.:.|.. ..::.:.|.|.....|:.|.|...||...||:.|..|:..
Zfish    77 PSDPIANPIAAFKLVKRLKSEWLN-VVHSTEAEENIKVLREDYRRMESSLPKLEDLRGAAHGLMR 140

  Fly   150 LMSFYDLKPEELAAGNLAGYSQP--------GTGLTAYDCLALGEFSVQKREDDLAEAWYNLSLI 206
            |...|:|..|.|..|:....|.|        ...|:..||..:|:.:.     || |.:|: |::
Zfish   141 LQDVYNLHVESLVRGHFQQISDPVDFYKLSVSDMLSGDDCFLVGKVAY-----DL-EDYYH-SVL 198

  Fly   207 RFENKFDKYRVHKAWGLLLAKNK-QLTD-----AFYHFE--NKPEGIIASNEV---------IHF 254
            .||.....:| ...|.   .:|: .|.|     ||.||:  |....:..|.|:         :||
Zfish   199 WFEEAVRLFR-GTEWS---PENEGTLEDALDHLAFSHFKTGNISHALSLSRELLLHDPMNRRVHF 259

  Fly   255 KEE--------------------------LSTK----QNCAVVVQKPSR-----LHCRYNTTTTP 284
            ..|                          |.|:    |.|.....:|..     |.|.|.|..:|
Zfish   260 NVEKYEKLLNENLPATSSGLTLKRPDGIYLRTRNAYEQLCQTKGSQPKHFENPSLFCDYFTNGSP 324

  Fly   285 FTRIAPLKMEELGLDPYMVVFHDVIYDTEIDGMLNSSNFGL--SLTDSGQK---SEVRTSKDSYI 344
            ...:.|::.|.:.|.||:|:||..:...|...:...:..||  |:..||..   :|.|.||.:::
Zfish   325 ALFLQPIRREIISLQPYVVLFHGFVTQAEAKNIRKYAMPGLRRSVVASGMNQATAEYRISKSAWL 389

  Fly   345 VDAK-----TLNERVTDMTGFSME--MSDPFSLINYGLGGHYMLHYDFHEYTNTT---RPKQGDR 399
            .::.     .|::|:|.:||.:::  .::...::|||:||||..|:| |..::::   |.|.|:|
Zfish   390 KESAHEVVGKLDQRITLVTGLNVQPPYAEYLQVVNYGIGGHYEPHFD-HATSDSSPLYRLKTGNR 453

  Fly   400 IATVLFYLGEVDSGGATIFPMINITVTPKKGSAVFWYNLHNSGAMNLKSLHSACPVISGSKYVLT 464
            :||::.||..|.:||:|.|...|.:|...:.:|:||:|||.:|..|:.:||:.||||.|:|:.:.
Zfish   454 VATIMIYLSPVQAGGSTAFIYANFSVPVVQNAALFWWNLHKNGQGNVDTLHAGCPVIVGNKWGMF 518

  Fly   465 KWINELPQMFVTPCMKDSNL-HP 486
            |..|    .....|...:|: ||
Zfish   519 KNKN----FHKVTCTAVTNIVHP 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15864	NP_652183.2	P4Ha_N	35..166	CDD:285528	31/130 (24%)
		metallo-dependent_hydrolases	<237..>306	CDD:294200	24/114 (21%)
		P4Hc	313..467	CDD:214780	57/168 (34%)
p4ha3	XP_021322008.1	P4Ha_N	27..157	CDD:311993	31/130 (24%)
p4ha3	XP_021322008.1	P4Hc	350..519	CDD:214780	56/169 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583399
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.850