DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15864 and p4ha1a

DIOPT Version :9

Sequence 1:	NP_652183.2	Gene:	CG15864 / 50001	FlyBaseID:	FBgn0040528	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	XP_009304776.1	Gene:	p4ha1a / 562774	ZFINID:	ZDB-GENE-040724-91	Length:	541	Species:	Danio rerio

Alignment Length:	552	Identity:	153/552 - (27%)
Similarity:	255/552 - (46%)	Gaps:	88/552 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LIGFLSACFINCQGFVKSNPKKS-YAASTMELMKLLEVEDELVDNLKGYVKTLKMKFNLMERSLI 72
            ::|..|.|.......:||:...| :..|...:..||..|.:||.:||.|:|..:.|...:::...
Zfish     1 MMGVRSVCCFLLISLLKSSSAHSDFFTSIGHMTDLLFTEKDLVTSLKDYIKAEESKLEQVKQWAE 65

  Fly    73 DMSRENMEMKSDYESYLGNPLNSFRLIHRLHTSWRKWYQYAIKVENNALGHIENARLMRKMLPTS 137
            .:.........|.|.:||:|:|:|:|:.||:|.|.:.....:|..::  |.|.|..:.|:..|..
Zfish    66 KLDALTATAVQDPEGFLGHPVNAFKLMKRLNTEWGEVEDLVLKDMSD--GFISNLTIQRQYFPND 128

  Fly   138 SDLQQACRGIHDLMSFYDLKPEELAAGNLAGYSQPGTG------LTAYDCLALGEFSVQKREDDL 196
            .|...|.:.:..|...|.|..:.:::|:|.|.:   ||      ||..||..||:.:....:...
Zfish   129 EDQNGAAKALLRLQDTYKLDTQTISSGDLPGVN---TGLPYKSTLTVEDCFELGKIAYSDADYYH 190

  Fly   197 AEAWYNLSLIRFEN------------KFDKYRVH-----------------------KAWGLL-- 224
            .|.|...:|.:.:.            .:..|.|:                       :|.|.|
Zfish   191 TELWMAQALKQLDEGEESSVEIATALDYLSYSVYQQGELERALEYTKRLLTVEPEHQRALGNLKY 255

  Fly   225 ----LAKNK-----QLTDAFYHFENKPEGIIASNEVIHFKEELSTKQNC-----AVVVQKPSRLH 275
                |||.|     |.|..    |:|.|...:..:..:..|:...::.|     .:..::...|.
Zfish   256 FDYQLAKQKKAEKEQSTKE----ESKKEQETSDGKKEYLPEKRKYEKLCRGEGLKMTPRRQKHLF 316

  Fly   276 CRY-NTTTTPFTRIAPLKMEELGLDPYMVVFHDVIYDTEIDGM-------LNSSNFGLSLTDSGQ 332
            ||| |....||..|.|:|.|:....|.::.:|::|.:.||:.:       |..:.....:|...:
Zfish   317 CRYFNGNRHPFYTIGPVKQEDEWDRPRIIRYHEIITEQEIEKIKELSKPRLRRATISNPITGVLE 381

  Fly   333 KSEVRTSKDSY-------IVDAKTLNERVTDMTGFSMEMSDPFSLINYGLGGHYMLHYDFHEYTN 390
            .:..|.||.::       :||  .:|:|:.|:||.:::.::...:.|||:||.|..|:||.....
Zfish   382 TAHYRISKSAWLAAYEHPVVD--RINQRIEDITGLNVKTAEELQVANYGVGGQYEPHFDFGRKDE 444

  Fly   391 TTRPKQ---GDRIATVLFYLGEVDSGGATIFPMINITVTPKKGSAVFWYNLHNSGAMNLKSLHSA 452
            ....|:   |:||||.|||:.:|.:||||:||.:...|.|.||:|||||||..||..:..:.|:|
Zfish   445 PDAFKELGTGNRIATWLFYMSDVAAGGATVFPEVGAAVKPLKGTAVFWYNLFPSGEGDYSTRHAA 509

  Fly   453 CPVISGSKYVLTKWINELPQMFVTPC-MKDSN 483
            |||:.|:|:|..|||:|..|.|..|| :|:::
Zfish   510 CPVLVGNKWVSNKWIHERGQEFRRPCGLKETD 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15864	NP_652183.2	P4Ha_N	35..166	CDD:285528	35/130 (27%)
		metallo-dependent_hydrolases	<237..>306	CDD:294200	17/74 (23%)
		P4Hc	313..467	CDD:214780	61/170 (36%)
p4ha1a	XP_009304776.1	P4Ha_N	28..157	CDD:285528	35/130 (27%)
		TPR repeat	172..207	CDD:276809	7/34 (21%)
		TPR repeat	212..242	CDD:276809	2/29 (7%)
		Fis1	218..262	CDD:304536	6/43 (14%)
		P4Hc	352..525	CDD:214780	62/174 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583431
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.850