DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15864 and CG18233

DIOPT Version :9

Sequence 1:	NP_652183.2	Gene:	CG15864 / 50001	FlyBaseID:	FBgn0040528	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	NP_649044.3	Gene:	CG18233 / 40025	FlyBaseID:	FBgn0036795	Length:	515	Species:	Drosophila melanogaster

Alignment Length:	519	Identity:	167/519 - (32%)
Similarity:	266/519 - (51%)	Gaps:	72/519 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 SACFINCQGFVKSNP-----KKSYAASTMELMKLLEVEDELVDNLKGYVKTLKMKFNLMERSLID 73
            :|..|..|....::|     :|.|::|.:.|:|||::|.|.:.|...|...|:.|.:.:...|..
  Fly     8 AAVLILVQSIHSTDPNDFLNRKYYSSSVLGLVKLLKMEQEFMVNFSIYANILQEKVDNLNIFLDA 72

  Fly    74 MSRENMEMKSDYESYLGNPLNSFRLIHRLHTSWRKWYQYAIKVENNALGHIENARLMRKML---P 135
            :.|.|.:..::.|.::.||||:|.||.||:..|.|...|..|    .|| :|....|:.::   |
  Fly    73 LKRPNHKTHNEREKFVSNPLNAFGLIRRLNQDWPKLQNYTQK----PLG-LEQLTAMQDIVSAAP 132

  Fly   136 TSSDLQQACRGIHDLMSFYDLKPEELAAGNLAGYSQPGTGLTAYDCLALGEFSVQKREDDLAEAW 200
            .|.|:.:..:.:|.:.:.|||:|:::|.| |...::....|...|||||.....:..|...:..|
  Fly   133 ESFDMNEKLKAMHRIETTYDLQPKDIAKG-LLQRTEFNYRLLFRDCLALAYHKFEIGEFKRSLLW 196

  Fly   201 YNLSL-------IRFENKFDKYRVHKAWGLLLAK-------------------NKQLTDA-FYHF 238
            :..:|       :...|:..:..: |.:...:||                   |.||.|| ....
  Fly   197 FQEALKLSTDGSLEIMNRLKEIEL-KGFATAVAKRSIYLSNQGLTNETIDDMANSQLQDAKLMDL 260

  Fly   239 ENKPEGIIASNEVIHFKEELST------KQNCAVVVQKPSRLHCRYNTTTTPFTRIAPLKMEELG 297
            |.     :.|:|:..:..:.||      ...|..:..|.|.|.||||::|..|.::|||||||:.
  Fly   261 EQ-----LISSELKQWINDDSTTPPTDHNLGCRGLFPKKSNLVCRYNSSTNAFLKLAPLKMEEIS 320

  Fly   298 LDPYMVVFHDVIYDTEIDGMLNS-SNFGLSLTDSGQKSEVRT-----SKDSYIVDAKTLNERVTD 356
            .|||:|:||:||.|.:|:.|... :......|..|...|:.:     .|:|..  :|.:|:|::|
  Fly   321 RDPYIVMFHEVISDKDIEEMKGEITEMENGWTSLGDPKEIVSRVYWIRKESSF--SKRINQRISD 383

  Fly   357 MTGFSMEMSDPFSLINYGLGGHYMLHYDFHEYTNTTRPKQ-------GDRIATVLFYLGEVDSGG 414
            ||||.:|......|.|:|:||::..||||:    |.|.|:       ||||.:::||.|||..||
  Fly   384 MTGFKLEEFPAIQLANFGVGGYFKPHYDFY----TDRLKEVDVNNTLGDRIGSIIFYAGEVSQGG 444

  Fly   415 ATIFPMINITVTPKKGSAVFWYNLHNSGAMNLKSLHSACPVISGSKYVLTKWINELPQMFVTPC 478
            .|:||.:.:.|.||||:|:||:|..:....:.:||||.|||:.||::.:|||::..||:||.||
  Fly   445 QTVFPDLKVAVEPKKGNALFWFNAFDDSTPDPRSLHSVCPVLVGSRWTITKWLHYAPQLFVKPC 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15864	NP_652183.2	P4Ha_N	35..166	CDD:285528	42/133 (32%)
		metallo-dependent_hydrolases	<237..>306	CDD:294200	26/74 (35%)
		P4Hc	313..467	CDD:214780	62/166 (37%)
CG18233	NP_649044.3	P4Ha_N	34..163	CDD:285528	42/134 (31%)
		ATP-synt_B	<198..278	CDD:304375	14/85 (16%)
		P4Hc	333..498	CDD:214780	64/170 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461790
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	10	9.900