DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15864 and CG18234

DIOPT Version :9

Sequence 1:	NP_652183.2	Gene:	CG15864 / 50001	FlyBaseID:	FBgn0040528	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	NP_649043.3	Gene:	CG18234 / 40024	FlyBaseID:	FBgn0265268	Length:	515	Species:	Drosophila melanogaster

Alignment Length:	526	Identity:	153/526 - (29%)
Similarity:	245/526 - (46%)	Gaps:	79/526 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYILKNLTLIGF---LSACFINCQGFVKSNPKKSYAASTMELMKLLEVEDELVDNLKGYVKTLKM 62
            |:|:.::.||..   :..|.|.           :.|.|...:.:|:::|...:..::.|...||.
  Fly     1 MFIILSICLISLGPPIGLCEIT-----------NSAMSIAGMKELVDLEGFFISEMESYTAALKN 54

  Fly    63 KFNLMERSLIDMSRENMEMKSDYESYLGNPLNSFRLIHRLHTSWRKWYQYAIKVENNALGHIENA 127
            |.:|||..|.::..:....:.:.|.::.:|||:|.||.|||..|.:  ...:.:....|.|::..
  Fly    55 KIDLMESLLQEVQSKREISRRNPEEFVAHPLNAFSLIRRLHEDWTQ--AELLMLNQVGLEHLQAI 117

  Fly   128 RL-MRKMLPTSSDLQQACRGIHDLMSFYDLKPEELAAGNLAGYSQPGTGLTAYDCLALGEFSVQK 191
            .. :.:..|:.:||..|..||..|..||:|:|.::|.|.|.| .|....||..:|.||....:..
  Fly   118 ETGLEEAQPSDNDLNDAIGGIISLQQFYNLQPSDIANGLLMG-QQYNASLTTLNCQALANACMNF 181

  Fly   192 REDDLAEAWYNLSLIRFENKFDKYRVHKAWGLLLAKNKQLTDAFYHFEN--KPEGI-IASNEVIH 253
            ..|..|..|:..::..:.:..|.....:.:..      :|.|.:.::.:  ..:|. .|:.:|:.
  Fly   182 NYDKYALNWFKAAVDHYNDDRDGQVYREVFDF------RLPDLYINYTSVLVTKGFRKAAWKVLQ 240

  Fly   254 FKEELSTK-----------------------------QNCAVVVQKPSRLHCRYNTTTTPFTRIA 289
            ...:|...                             ..|..|.|....|.|.|...|:.|.|||
  Fly   241 DVADLDATLWLLRKDIYEVGKIDVPDPTFIITPWFDVTGCLRVGQTSQHLSCHYEKNTSEFLRIA 305

  Fly   290 PLKMEELGLDPYMVVFHDVIYDTEIDGMLNSSNFGLSLTDSGQKSEVRTSKDSYIVD-----AK- 348
            |||:|.|.|.|::|::||||||:||..:.|.|...|       ||.:|.   .|.:|     ||
  Fly   306 PLKVETLSLKPHIVLYHDVIYDSEISKVKNISLPSL-------KSPLRI---LYAIDYNLKFAKI 360

  Fly   349 ------TLNERVTDMTGFSMEMSDPFSLINYGLGGHYMLHYDFHEYTNTTRPKQGDRIATVLFYL 407
                  .|:.|:.||||..::....|.:.|||:.|....|.|..|..:.| .:.|||:.:::|::
  Fly   361 REDHQSPLSLRIKDMTGEDVQEDTDFQIDNYGICGFRNFHTDNIELQDQT-AELGDRLTSIMFFM 424

  Fly   408 GEVDSGGATIFPMINITVTPKKGSAVFWYNLHNSGAMNLKSLHSACPVISGSKYVLTKWINELPQ 472
            .:|..|||..||.:|:|:.|:||||:.|.||.:....|...||.:|||:.|||:.|.||::|.||
  Fly   425 NDVAQGGALAFPNLNLTIWPQKGSALVWRNLDHRMQPNQDLLHVSCPVVVGSKWTLVKWLHERPQ 489

  Fly   473 MFVTPC 478
            ||..||
  Fly   490 MFSRPC 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15864	NP_652183.2	P4Ha_N	35..166	CDD:285528	37/131 (28%)
		metallo-dependent_hydrolases	<237..>306	CDD:294200	23/100 (23%)
		P4Hc	313..467	CDD:214780	58/165 (35%)
CG18234	NP_649043.3	P4Ha_N	27..157	CDD:285528	37/131 (28%)
CG18234	NP_649043.3	P4Hc	<371..485	CDD:214780	46/114 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461932
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	9	8.900