DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15864 and CG32201

DIOPT Version :9

Sequence 1:	NP_652183.2	Gene:	CG15864 / 50001	FlyBaseID:	FBgn0040528	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	NP_730346.2	Gene:	CG32201 / 317911	FlyBaseID:	FBgn0052201	Length:	520	Species:	Drosophila melanogaster

Alignment Length:	523	Identity:	171/523 - (32%)
Similarity:	267/523 - (51%)	Gaps:	68/523 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LIGF-LSACFINCQGFVKSNPKKSYAASTMELMKLLEVEDELVDNLKGYVKTLKMKFNLMERSLI 72
            |:|| :...|:.|...::.  |:.|::||:.|:|||:||::..|||...|..|..||..:...|.
  Fly    11 LLGFAVLNSFVGCVEDIEE--KERYSSSTVGLLKLLKVEEKFTDNLLNQVDQLGEKFEALRMYLS 73

  Fly    73 DMSRENMEMKSDYESYLGNPLNSFRLIHRLHTSWRKWYQYAIKVENNALGHIENARL--MRKMLP 135
            .:..|.....::...|:.||:|:|.|:.|.|....||::|.    ..|:|....:.|  :.||:|
  Fly    74 SVGYELHRSLNEKVQYVSNPINAFSLLRRTHEDLPKWHEYF----KEAIGEGNQSILVDLVKMVP 134

  Fly   136 TSSDLQQACRGIHDLMSFYDLKPEELAAGNLAGYSQPGTGLTAYDCLALGEFSVQKREDDLAEAW 200
            ...|:..|..||..:...||||.::||.|.|.|. |....||..|.:|:|....|:.:...|..|
  Fly   135 NDVDMLSAMHGIQRIEKIYDLKIDDLAQGVLQGV-QYNVQLTYRDLIAMGNSMYQQSDYQTAAKW 198

  Fly   201 YNLSLIR-FENKFDKY---------RVHKAWGLLLAK--------NKQLTDAFYHFENKPEGIIA 247
            |.::..| .||....:         .:|:.:...|.|        :|.:.:||...:...|
  Fly   199 YRIACKRELENPEQLFIQILGDPSEHLHRQYIKSLFKYGSTTSEPSKSIEEAFIMVQASQE---- 259

  Fly   248 SNEVIHFKEELSTKQN---------------------CAVVVQKPSRLHCRYNTTTTPFTRIAPL 291
              |:.:...:|:..||                     |..:.::.:.|.|||.:|...|.|:|||
  Fly   260 --ELDNIMSDLNEPQNDVEVEKDLYQVKRSPSNCELGCRGLYRQKTNLVCRYKSTANTFLRLAPL 322

  Fly   292 KMEELGLDPYMVVFHDVIYDTEIDGMLNSS-NFGLSLTDSGQKSEVRTSKDSYIVDAKT------ 349
            |:||:.|||:|.::|:|:||:||..:...| |...........:|:|.:...|...:.|
  Fly   323 KLEEISLDPFMAMYHEVLYDSEIRELKGQSMNMVNGYASQRNGTEIRDTVVRYDWWSNTSLVRER 387

  Fly   350 LNERVTDMTGFSMEMSDPFSLINYGLGGHYMLHYDF----HEYTNTTRPKQGDRIATVLFYLGEV 410
            :|:|:.|||||:....:...:.|||||.::..|:|:    .|..|.|  ..|||:|::|||..||
  Fly   388 INQRIIDMTGFNFLKDEKLQIANYGLGTYFQPHFDYSSDGFETPNIT--TLGDRLASILFYASEV 450

  Fly   411 DSGGATIFPMINITVTPKKGSAVFWYNLHNSGAMNLKSLHSACPVISGSKYVLTKWINELPQMFV 475
            ..||||:||.||:||.|:|||.::|:|||:.|..:::||||.|||::|.::.||||:...||||.
  Fly   451 PQGGATVFPEINVTVFPQKGSMLYWFNLHDDGKPDIRSLHSVCPVLNGDRWTLTKWVPMFPQMFS 515

  Fly   476 TPC 478
            .||
  Fly   516 FPC 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15864	NP_652183.2	P4Ha_N	35..166	CDD:285528	45/132 (34%)
		metallo-dependent_hydrolases	<237..>306	CDD:294200	23/89 (26%)
		P4Hc	313..467	CDD:214780	64/164 (39%)
CG32201	NP_730346.2	P4Ha_N	36..165	CDD:285528	45/132 (34%)
CG32201	NP_730346.2	P4Hc	341..507	CDD:214780	66/167 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461774
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	10	9.900