Protein Alignment Cadps and Cadps2

DIOPT Version :10

• Sequence 1: NP_001245439.1
• Gene: Cadps / 49968
• FlyBaseID: FBgn0053653
• Length: 1534
• Species: Drosophila melanogaster
• Sequence 2: XP_006505170.1
• Gene: Cadps2 / 320405
• MGIID: 2443963
• Length: 1309
• Species: Mus musculus
• Alignment Length: 1509
• Identity: 783/1509 - (51%)
• Similarity: 986/1509 - (65%)
• Gaps: 244/1509 - (16%)

  Fly     1 MIDPSSSEEEGEDDAVPNVSSKGRLTNTTKGTSAVSIIGGSAGSVVGSNIPVSGSNTDLIGNQRQ 65
            |:||||||||.::    .:..:.|......|.|                             ||.
Mouse     1 MLDPSSSEEESDE----GLEEESREVLVAPGVS-----------------------------QRA 32

  Fly    66 SNISSICNRNDVGNISVAALGSTSNKIEQICGNRADTGNLEVPSNGIPSGISQETLNQSVGSSRA 130
            ...:                              |..|..:.|...              |....
Mouse    33 PPAA------------------------------AREGRRDAPGRS--------------GGGSG 53

  Fly   131 NSLPRPLSPSPSLTSEKHETAEPHGKHE-----REEEERKRRIQLYVFISRCISYPFNAKQPTDM 190
            ....||:|||||:.||        |::|     .||:||:.|:|||||:.|||:|||||||||||
Mouse    54 GGAARPVSPSPSVLSE--------GRNEPELQLDEEQERRIRLQLYVFVVRCIAYPFNAKQPTDM 110

  Fly   191 TKRQTKISKQQLEIITQRFQAFLKGETQIMADEAFQNAVQSYHDVFLKSERVLKMVQSGASSQHD 255
            .:||.|::||||:::.:||||||.|||||:|||||.|||:||::|||||:||.:|||||..|.:|
Mouse   111 ARRQQKLNKQQLQLLKERFQAFLNGETQIVADEAFCNAVRSYYEVFLKSDRVARMVQSGGCSAND 175

  Fly   256 FREVFRNNIEKRVRSLPEIDGLSKETVLTSWMAKFDIILKGTGEED-SKRPSRMQQSLNSELILS 319
            |||||:.|||||||||||||||||||||:||:||:|.|.:  |||| .|:|:||..|..||||||
Mouse   176 FREVFKKNIEKRVRSLPEIDGLSKETVLSSWIAKYDAIYR--GEEDLCKQPNRMTLSAVSELILS 238

  Fly   320 KEQLYDMFQQILLVKKFEHQILFNALMLDSADEQAAAIRRELDGRMQRVGEMEKNRKLMPKFVLK 384
            |||||:||||||.:||.|||:|:||..||:||||||.||||||||:|...:|.|.|: .|:|:.|
Mouse   239 KEQLYEMFQQILGIKKLEHQLLYNACQLDNADEQAAQIRRELDGRLQLAEKMAKERR-FPRFISK 302

  Fly   385 EMESLYVEELKSSINLLMANLESLPVSKGNMDSKYGLQKLKRYNHSTPSFLKLILRSHGSLSKLE 449
            ||||:|:|||::|:|||||||||||||||..:.|  ||||||..:|  :||.|
Mouse   303 EMESMYIEELRASVNLLMANLESLPVSKGGPEFK--LQKLKRSQNS--AFLDL------------ 351

  Fly   450 GDSEDGSTQLTKLDVVLTFQLEVIVMEVKGLKSLAPNRIVYCTMEVENGEKLQTDQAEASKPMWD 514
            ||  :...||:|.||||:|.||:::|||:||||:|||||||||||||.||||||||||||:|.|.
Mouse   352 GD--ENEIQLSKSDVVLSFTLEIVIMEVQGLKSVAPNRIVYCTMEVEGGEKLQTDQAEASRPQWG 414

  Fly   515 TQGDFTTTHPLPVVKVKLYTENPGMLALEDKELGKVTLKPTPLSSKSPEWHRMIVPKNLPDQDIR 579
            |||||.||||.|||||||:||:.|:|||||||||:|.|.||..||||.|.|||.||||..|.|::
Mouse   415 TQGDFNTTHPRPVVKVKLFTESTGVLALEDKELGRVVLYPTSNSSKSAELHRMTVPKNSQDSDLK 479

  Fly   580 IKIACRLDKPLNMKHCGYLYAIGKSVWKKWKRRYFVLVQVSQYTFAMCSYKEKKSEPSEMMQLDG 644
            ||:|.|:|||.:|||.|||||:|:.|||:||:||||||||||||||||||:||||||.|:|||:|
Mouse   480 IKLAVRMDKPAHMKHSGYLYALGQKVWKRWKKRYFVLVQVSQYTFAMCSYREKKSEPQELMQLEG 544

  Fly   645 YTVDYIEAASANLMFGIDLNGGRYFFNAVREGDSISFACDDENECSLWVMAMYRATGQSHKPTPP 709
            |||||.:....       |.||:.|||||:|||::.||.|||.:..|||.|||||||||:||.|.
Mouse   545 YTVDYTDPHPG-------LQGGQVFFNAVKEGDTVIFASDDEQDRILWVQAMYRATGQSYKPVPA 602

  Fly   710 ITQDK-NSAMSKIQGD----ADKARKHGMEDFISTDPCTFDHATLFKTLQNLTLEYRLNDPYASL 769
            :...| |.....:..|    ||:.:||||::|||..||..|||.||:.||..||::||||.|:.|
Mouse   603 VQSQKLNPKGGALHADAQLYADRFQKHGMDEFISASPCKLDHAFLFRILQRQTLDHRLNDSYSCL 667

  Fly   770 GWFSPGQVFVLDEYCARYGVRGCYRHLCYLSDLLDRAEKQHMIDPTLIHYSFAFCASHVHGNRPD 834
            |||||||||||||||||||||||:||||||::|::.:|...:|||||:|||||||||||||||||
Mouse   668 GWFSPGQVFVLDEYCARYGVRGCHRHLCYLTELMEHSENGAVIDPTLLHYSFAFCASHVHGNRPD 732

  Fly   835 GVGSITHEEKEKFSEIKERLRQLLEFQITNFRYCFPFGRPEGALKATLSLLERVLMKDIVTPVPP 899
            |:|:::.||||:|.|||:||..|||.||::|||||||||||||||||||||||||||||.||:|.
Mouse   733 GIGTVSVEEKERFEEIKDRLSSLLENQISHFRYCFPFGRPEGALKATLSLLERVLMKDIATPIPA 797

  Fly   900 EEVRQMIKKSLETAALVNYTRLSNKAKID-----EDLRGDVIVPAPKKLEDLIHLAELCVDLLQQ 959
            |||:::::|.||.|||:|||||:..|||:     |....:...|| :|||:::||||||:::|||
Mouse   798 EEVKKVVRKCLEKAALINYTRLTEYAKIEGPAEKETETMNQATPA-RKLEEVLHLAELCIEVLQQ 861

  Fly   960 NEEHYGELRKHDKMDKKKLLKEDEDVSGGHNESEVDLIDSTGLISASELATAASTDGSSFRYCMP 1024
            ||||:.|.|:
Mouse   862 NEEHHAEGRE------------------------------------------------------- 871

  Fly  1025 THAVYTPPVPTAFAWFSDLLVEHAEIFWSLFAVDMDRVLSEQAPDTWDSFPLFQILNDYLRTDDN 1089
                       ||||:.|||.||||.||:||.||||..|..|..|:||||||||:||::||.|..
Mouse   872 -----------AFAWWPDLLAEHAEKFWALFTVDMDTALEAQPQDSWDSFPLFQLLNNFLRNDTL 925

  Fly  1090 LRNGRFHQHLRDTFAPLVVRYVDLMESSIAQSIHKGFEKERWESKGINAALNPAALNNAAQALNT 1154
            |.||:||:||::.|.||||||||||||:||||||:|||:|.|:           .:.|.|.:|..
Mouse   926 LCNGKFHKHLQEIFVPLVVRYVDLMESAIAQSIHRGFEQETWQ-----------PVKNIANSLPN 979

  Fly  1155 AALN--PSMILCGKKDQVNFYVPKLPKQSNS--TAANDEMRNGCATSEDLFWKLDALQSFIRDLH 1215
            .||.  ||:.|         .:|::|..|..  .|:..|..||..|||||||||||||.|:.|||
Mouse   980 VALPKVPSLPL---------NLPQIPSFSTPPWMASLYESTNGSTTSEDLFWKLDALQMFVFDLH 1035

  Fly  1216 WPDAEFRQHLEQRLKMMAVDMIEQCIQRTDSSFQSWLKKNIAFISTDYILPSEMCAMVNVILDAK 1280
            ||:.||..|||||||:||.||||.|::||.::|:..|:|  |..:||..:|:.:|.|.||::|||
Mouse  1036 WPEQEFAHHLEQRLKLMASDMIEACVKRTRTAFELKLQK--ANKTTDLRIPASVCTMFNVLVDAK 1098

  Fly  1281 NQSFKLTTIDGIDLYK-----FHAKIDDQIDKANVAMTQGLSGKLMSVLESTLSKLARYDEGSLI 1340
            .||.||..:||...::     :|:||||.||.....:...|..|.:||||..||||:|||||:..
Mouse  1099 KQSTKLCALDGGQEFRNQWQQYHSKIDDLIDNTVKEIIALLVSKFVSVLEGVLSKLSRYDEGTFF 1163

  Fly  1341 GSILSFT--------NVSSSGKDLGQGYVNFFRNNMDQVRGKIADDLWTLHFFEQWYSQQINMLC 1397
            .||||||        :|...|.||...|:.|.|.|.|.:|.|:.::::....|:||||..:.::|
Mouse  1164 SSILSFTVKAAAKYVDVPKPGMDLADTYIMFVRQNQDILREKVNEEMYIEKLFDQWYSNSMKVIC 1228

  Fly  1398 NWLSERVDHALHYAQVASISHIIKKIYSDFELQGVLEDKLNSKAYQAVAQRMATEEATCA----- 1457
            .||::|:|..||..|:.::..|:||.|.||.||||||..||||.|..:.:|:..||||.:
Mouse  1229 VWLADRLDLQLHIYQLKTLIKIVKKTYRDFRLQGVLEGTLNSKTYDTLHRRLTVEEATASVSEGG 1293

  Fly  1458 ----LTMPDACEDE 1467
                :||.|:.|:|
Mouse  1294 GLQGITMKDSDEEE 1307

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cadps	NP_001245439.1	PH_CADPS	585..711	CDD:269940	83/125 (66%)
		MUN	904..1427	CDD:461870	229/544 (42%)
Cadps2	XP_006505170.1	C2	369..452	CDD:214577	65/82 (79%)
		PH_CADPS	485..604	CDD:269940	83/125 (66%)
		MUN	802..1258	CDD:461870	229/544 (42%)