Protein Alignment Cadps and unc-31

DIOPT Version :10

• Sequence 1: NP_001245439.1
• Gene: Cadps / 49968
• FlyBaseID: FBgn0053653
• Length: 1534
• Species: Drosophila melanogaster
• Sequence 2: NP_001293901.1
• Gene: unc-31 / 178233
• WormBaseID: WBGene00006767
• Length: 1401
• Species: Caenorhabditis elegans
• Alignment Length: 1588
• Identity: 715/1588 - (45%)
• Similarity: 965/1588 - (60%)
• Gaps: 274/1588 - (17%)

  Fly     1 MIDPSSSEEEGED-----DAVPNVSSKGRLTNTTKGTSAVSIIGGSAGSVVGSNIPVSGSNTDLI 60
            |:..||||||.:|     |::|....|.|           |::.|:  ....|:.|....:....
 Worm     1 MLGASSSEEEDDDFQEDHDSLPIAQVKKR-----------SLLSGA--MTPRSSSPAPSDSVSQT 52

  Fly    61 GNQRQSNISSICNRNDVGNISVAALGSTSNKIEQICGNRADTGNLEVPSNGIPSGISQETLNQS- 124
            .:.:::|.||...|.|    ||.:.....:.:..       .....:|...|.|.:|:..:..|
 Worm    53 NSLKRNNSSSQGRRKD----SVQSQTPARSPMRM-------NAPSPMPQARIMSNVSKPIMQNSQ 106

  Fly   125 ----------------VGSSRANSLPRPLSPSPSLTSEKHETAEPHGKHEREEEERKRRIQLYVF 173
                            |||...       ...|:|:.|:.|..    |.|||||:.|:.:|:|:|
 Worm   107 EFDGDEEEGEEGSTTVVGSGDE-------CGGPALSKEEQERM----KAEREEEDHKKNLQMYMF 160

  Fly   174 ISRCISYPFNAKQPTDMTKRQTKISKQQLEIITQRFQAFLKGETQIMADEAFQNAVQSYHDVFLK 238
            ::|||:||||.:|..||.:||.|::||:|..|.:||..||||||.|.|||||..|:|||.:||||
 Worm   161 LARCIAYPFNGQQTGDMARRQMKVNKQELARIRERFTLFLKGETNIAADEAFTKAIQSYFEVFLK 225

  Fly   239 SERVLKMVQSGASSQHDFREVFRNNIEKRVRSLPEIDGLSKETVLTSWMAKFDIILKGTGEEDSK 303
            ||||.|:|.:|..||||||||||.||||||||||:|:||||:|||.||:||||.|:|| .|.|..
 Worm   226 SERVQKVVHAGGFSQHDFREVFRLNIEKRVRSLPDIEGLSKDTVLNSWLAKFDAIIKG-DETDQN 289

  Fly   304 RPSR-----MQQSLNSELILSKEQLYDMFQQILLVKKFEHQILFNALMLDSADEQAAAIRRELDG 363
            |.:|     .|.:::::.:|.||||||:|||||.||||||||:||||.||:.||||||||||...
 Worm   290 RNARGRSRNPQNAMSADAVLGKEQLYDVFQQILGVKKFEHQIIFNALQLDNPDEQAAAIRREFAT 354

  Fly   364 RMQRVGEMEKNRKLMPKFVLKEMESLYVEELKSSINLLMANLESLPVSKGNMDSKYGLQKLKRYN 428
            |.:.:.:..|.::|.||||:|:||:||::|::.|||.|:.|||::||:  ...:..|.:|.|..|
 Worm   355 REEALKDPIKMKRLTPKFVVKDMETLYMDEVRMSINTLIGNLETVPVT--TRGATVGKRKDKSRN 417

  Fly   429 HS----TPSFLKLIL-------RSHGSLSKLEGDSEDGSTQLTKLDVVLTFQLEVIVMEVKGLKS 482
            .:    :.|...|.|       .|.|||:|  ||||||...|||.||.|...:||:||||:||||
 Worm   418 QTKNKRSRSIEDLSLFNSLKRRTSSGSLNK--GDSEDGDVTLTKSDVSLALSMEVVVMEVQGLKS 480

  Fly   483 LAPNRIVYCTMEVENGEKLQTDQAEASKPMWDTQGDFTTTHPLPVVKVKLYTENPGMLALEDKEL 547
            :.|::||||||||: |.|||||.||||||.|||||||:|.:||||||||||||...|:|.|||||
 Worm   481 VQPSKIVYCTMEVD-GHKLQTDHAEASKPKWDTQGDFSTKNPLPVVKVKLYTEVKSMIAFEDKEL 544

  Fly   548 GKVTLKPTPLSSKSPEWHRMIVPKNLPDQDIRIKIACRLDKPLNMKHCGYLYAIGKSVWKKWKRR 612
            |||.::|||..::||||:.|.:||:..||:::|:||.|::||.|:|:|||.|.||::.|||||:|
 Worm   545 GKVIIQPTPNCARSPEWYTMTLPKSSQDQNLKIRIAIRVEKPPNLKYCGYCYCIGRNAWKKWKKR 609

  Fly   613 YFVLVQVSQYTFAMCSYKEKKSEPSEMMQLDGYTVDYIEAASANLMFGIDLNGGRYFFNAVREGD 677
            :|.|||||||.||:||:::||::|:|.:||||:|:||:..:...|    ...||::||.|::|||
 Worm   610 FFCLVQVSQYAFAVCSFRQKKADPTEFIQLDGFTIDYMPESDPEL----SAQGGKHFFTAIKEGD 670

  Fly   678 SISFACDDENECSLWVMAMYRATGQSHKPTPPITQDKNSAMS-KIQGDADKARKHGMEDFISTDP 741
            .:.||.|||||..|||.|:||||||::||.||    |.|.:: |.||..|||.||||:..|..|.
 Worm   671 ELKFATDDENERHLWVQALYRATGQAYKPVPP----KQSTIAPKAQGFQDKASKHGMDAMIQADS 731

  Fly   742 CTFDHATLFKTLQNLTLEYRLNDPYASLGWFSPGQVFVLDEYCARYGVRGCYRHLCYLSDLLDRA 806
            ..|||...:..:|.|||::|:|:|..|||||||||.|||:||.|||.||||:||:..||:|||:|
 Worm   732 INFDHDHFYSDVQRLTLDFRINEPICSLGWFSPGQAFVLEEYSARYMVRGCFRHVTLLSNLLDKA 796

  Fly   807 EKQHMIDPTLIHYSFAFCASHVHGNR-------PDGVGSITHEEKEKFSEIKERLRQLLEFQITN 864
            :...:|||.|||||||||||||||||       |:|||::|.||||||.|||||||.|||.||||
 Worm   797 DDGLLIDPALIHYSFAFCASHVHGNRCMPDRQGPEGVGTVTLEEKEKFQEIKERLRVLLEKQITN 861

  Fly   865 FRYCFPFGRPEGALKATLSLLERVLMKDIVTPVPPEEVRQMIKKSLETAALVNYTRLSNKAKIDE 929
            |||||||||||||||.||.|||||||||:|:||||||||.:|:|.||.||||||||:.|:|||::
 Worm   862 FRYCFPFGRPEGALKGTLGLLERVLMKDVVSPVPPEEVRAVIRKCLEDAALVNYTRICNEAKIEQ 926

  Fly   930 DLRGDVIVPAPKKLEDLIHLAELCVDLLQQNEEHYGE-LRKHDKMDKKKLLKEDEDVSGGHNESE 993
            .:..|| .|| :::||:|.:.|.|:|||::||||:|| ||
 Worm   927 RMGIDV-SPA-QRIEDMIRVTEFCIDLLKENEEHHGEQLR------------------------- 964

  Fly   994 VDLIDSTGLISASELATAASTDGSSFRYCMPTHAVYTPPVPTAFAWFSDLLVEHAEIFWSLFAVD 1058
                                                     .|||||||||.:|:||||||::||
 Worm   965 -----------------------------------------GAFAWFSDLLSDHSEIFWSLYSVD 988

  Fly  1059 MDRVLSEQAPDTWDSFPLFQILNDYLRTDDNLRNGRFHQHLRDTFAPLVVRYVDLMESSIAQSIH 1123
            :|..|..|..|:||||||||:|||:|.::.:|:.|.||..:...|.||||||:||||.||||:|.
 Worm   989 LDSALEVQPHDSWDSFPLFQMLNDFLLSESSLKGGIFHNKIVQQFQPLVVRYIDLMEHSIAQAID 1053

  Fly  1124 KGFEKERWESKGINAALNPAALNNAAQALNTAALNPSMILCGKKDQVNFYVPKLPKQSNSTAAND 1188
            |||.||:|||:
 Worm  1054 KGFSKEKWESR------------------------------------------------------ 1064

  Fly  1189 EMRNGCATSEDLFWKLDALQSFIRDLHWPDAEFRQHLEQRLKMMAVDMIEQCIQRTDSSFQSWLK 1253
              :.|||||||::||||||.:|:.||:||:.:||::|:.::|.:..|||.:....|.::|.||::
 Worm  1065 --KEGCATSEDIYWKLDALHTFVIDLNWPEEDFRKYLQTKMKSLTSDMISKVSDCTFTAFDSWMQ 1127

  Fly  1254 KNIAFISTDYILPSEMCAMVNVILDAKNQSFKLTTIDGIDLYKFHAKIDDQIDKANVAMTQGLSG 1318
            :  |..||||:||||:|..:||:..:|:::.::|...|  .||:.:|:|:.::.....|...:..
 Worm  1128 R--AKKSTDYMLPSEVCVQINVMFSSKSRAVRVTVDSG--EYKYQSKLDETLETMLKTMESCIQE 1188

  Fly  1319 KLMSVLESTLSKLARYDEGSLIGSILS------------------------------FTNVSSSG 1353
            ||..||||.||:|||||||:.||:||:                              .|...|||
 Worm  1189 KLHGVLESVLSRLARYDEGNPIGAILNIAPKPASIFNKLKTMAGDTSAQATTTARQPLTAQQSSG 1253

  Fly  1354 KDLGQGYVNFFRNNMDQVRGKIADDLWTLHFFEQWYSQQINMLCNWLSERVDHALHYAQVASISH 1418
            : :|..||.||....:.:|..|.|::|....||.||..|:..:..||:||:..:|...|..|:|.
 Worm  1254 Q-IGNSYVTFFHGCTELLRQVIIDEIWVNGLFEHWYDNQMKSINEWLTERLQQSLSATQYISLST 1317

  Fly  1419 IIKKIYSDFELQGVLEDKLNSKAYQAVAQRMATEEATCALTMPDACEDEPCDEIREGEEEDNGDE 1483
            |:||:|.||.|||:.|::||||.||::::|:..||:...:.                |...||..
 Worm  1318 IVKKVYQDFSLQGIDEERLNSKTYQSISRRLQLEESNSHIQ----------------EAAINGSA 1366

  Fly  1484 STSNIPRGLPKPKVAAAQAAAVTNVVAG 1511
            ..|..|..|..   |.|..:.::::|.|
 Worm  1367 QGSVFPTSLGN---ATAAVSNMSSMVEG 1391

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cadps	NP_001245439.1	PH_CADPS	585..711	CDD:269940	70/125 (56%)
		MUN	904..1427	CDD:461870	196/553 (35%)
unc-31	NP_001293901.1	PH_CADPS	582..704	CDD:269940	70/129 (54%)
		MUN	901..1326	CDD:461870	196/553 (35%)