Protein Alignment alpha-Catr and Ctnnal1

DIOPT Version :10

• Sequence 1: NP_726389.4
• Gene: alpha-Catr / 49713
• FlyBaseID: FBgn0029105
• Length: 810
• Species: Drosophila melanogaster
• Sequence 2: NP_061231.3
• Gene: Ctnnal1 / 54366
• MGIID: 1859649
• Length: 731
• Species: Mus musculus
• Alignment Length: 783
• Identity: 218/783 - (27%)
• Similarity: 379/783 - (48%)
• Gaps: 118/783 - (15%)

  Fly     7 STVNNQRFRVRDMDNEQIMSTFGNIGHLLNIAVERFITIGEIIAEENIDIKGDMYEAAKEARDAG 71
            :|:.|.:...:..|  :.:.....:|..:|:||.||:.:||.||.||.|:|.::..|..||:.||
Mouse    48 TTLINHKDNTKKSD--KTLQAIQRVGQAVNLAVGRFVKVGEAIANENWDLKEEINIACIEAKQAG 110

  Fly    72 KSIERLCDISPLSGMELRHHIEPLKDYGAIILAARSLLSSVTRILLLVDIIVVKKLLTAKKRASE 136
            ::|..|.|::..|.:|....:..|.|...::.|||.||||||::|||.|.:|:|:::|::.:...
Mouse   111 ETIASLTDVTKRSHLESDGQVTILTDKTGVVQAARLLLSSVTKVLLLADRVVIKQIVTSRNKILA 175

  Fly   137 SLEKLESVMNFTEFVRAFSVFGTEMIELAYLTGHHRNSFKEERRRAQMFSARQILEKSIAILLTS 201
            ::|:||.|.:|.|||:.||.||.||:|.|:|||..:|..|:|:::|:|..||.:|||...:|||:
Mouse   176 TMERLEKVNSFQEFVQIFSQFGNEMVEFAHLTGDRQNDLKDEKKKARMAVARAVLEKGTMMLLTA 240

  Fly   202 SKNSLIHSDCVIVKENRDTVFCQIRRAMDLIHFVVKDSIFDTAKHMPFEKQASNPNYENESIYTT 266
            ||..|.|..|.....|::.||.::|.|::.:..:|.|.           :.:...:..:.||:|.
Mouse   241 SKTCLRHPSCESAHTNKEGVFDRMRVALEKVTEIVTDC-----------RLSGETDSSSVSIFTG 294

  Fly   267 IKRIVNLIKRYKYQMSYYEGSGEGNNNSDAYFSFLDDDLWKSEKNLPSAAGGGRMVNNTNFRKHL 331
            ||.:                                                  .||....|:::
Mouse   295 IKEL--------------------------------------------------KVNIEALRENV 309

  Fly   332 SSESLDLREELSLAFEKLFEKAHDFTDSPYISHNHRKNILSYCDNCKLEFDLYLNTIMKDQHEGG 396
            ..||   :|.||.|.|.:.|...|||||.|.||.||:.||......:.|....|:..|:.|....
Mouse   310 CFES---KENLSAALEAVLEHVEDFTDSAYTSHEHRERILELSSQARTELQQLLSVWMQTQSRKT 371

  Fly   397 GGAGGVGGVGGGQVKGRSDPELGMLS---SLEELCKQL---VVSVSSQIEDFNESLKICSKLVKS 455
            ..|.             .:.||.:|.   ||:||.::|   .:.:::.:..|:..    ..::|:
Mouse   372 KSAA-------------EELELTVLKISHSLDELRRELHCTAMQLAADLLKFHAD----HVVLKA 419

  Fly   456 FHVLATNYDIDNLNQRSSKFHDCCDHIFDICKLLQHIAPTERLQVQAKCLAINLRIYGPQVFIAA 520
            ..|.....:::.|.:.:.|..:..:.:.:.|:||:||:.||.|::.........::.|.|:..||
Mouse   420 LKVTGVEGNLEALAEYACKLSEQKEQLVETCRLLRHISGTEPLEITCIHAEETFQVTGQQIISAA 484

  Fly   521 KILWKYSNSSAANENFESFSDMWKWLTNEISMIAKKILVSINTTKGDRDADAEKCE--------- 576
            :.|..:.:|..|.||.:.|.:.|:...::::.:.::|.......:|      |:|:
Mouse   485 ETLTLHPSSKIAKENLDVFCEAWESQMSDMATLLREISDVFEGRRG------ERCDHLSLPKPTK 543

  Fly   577 -SSSDKLTKSGVPATEDGEMVEYSGLE-GKNNGDLNTYQSKWSEDLSDDNDILKRAKNMSAMAFL 639
             |::.|..|...|.:|:...:...||: |..:.|.:....||.:   ::|:|::..:|||.||:.
Mouse   544 NSANLKSLKPDKPDSEEQAKIAKLGLKLGLLSSDADCEIEKWED---EENEIVRHGRNMSRMAYS 605

  Fly   640 MYQFTKGNGSLRTTQDLFTQAEYFAEEANRLYKVLRHFSYQVPASDNKKDLLNILDRVPTFVQAL 704
            :|.||:|.|.|:|:|||....|.||.|..:|...::.||.|:...|....||.|...:|...| |
Mouse   606 LYLFTRGEGPLKTSQDLIHFLEVFAAEGLKLTSSVQSFSKQLKDDDKLMLLLEINKLIPLCHQ-L 669

  Fly   705 QFTVKDHTVGKAATFVKVDHVIRETKNLMNVINKVVSKCFECATKYKLNLTGITGGLTSERSNEN 769
            |...|  |..::..|:|||..|.:.:::|.::.:::|.|::...|.:.|..|      |..:.:.
Mouse   670 QTITK--TSLQSKVFLKVDKCITKIRSMMTLVVQLLSLCYKLLKKMENNRWG------SATNKDT 726

  Fly   770 MAG 772
            |.|
Mouse   727 MDG 729

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Catr	NP_726389.4	Vinculin	38..755	CDD:460040	209/733 (29%)
Ctnnal1	NP_061231.3	Vinculin	30..674	CDD:460040	202/718 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	535..559		4/23 (17%)