Protein Alignment alpha-Catr and Ctnnal1

DIOPT Version :10

• Sequence 1: NP_726389.4
• Gene: alpha-Catr / 49713
• FlyBaseID: FBgn0029105
• Length: 810
• Species: Drosophila melanogaster
• Sequence 2: NP_001100119.1
• Gene: Ctnnal1 / 298019
• RGDID: 1311434
• Length: 731
• Species: Rattus norvegicus
• Alignment Length: 754
• Identity: 210/754 - (27%)
• Similarity: 373/754 - (49%)
• Gaps: 100/754 - (13%)

  Fly     7 STVNNQRFRVRDMDNEQIMSTFGNIGHLLNIAVERFITIGEIIAEENIDIKGDMYEAAKEARDAG 71
            :|:.|.:...:..|  :.:.....:|..:|:||.||:.:||.||.||.|:|.::..|..||:.||
  Rat    48 TTLINHKDNTKKSD--KTLQAIQRVGQAVNLAVGRFVKVGEAIANENWDLKEEISIACIEAKQAG 110

  Fly    72 KSIERLCDISPLSGMELRHHIEPLKDYGAIILAARSLLSSVTRILLLVDIIVVKKLLTAKKRASE 136
            ::|..|.|::..:.:|....:..|.|...::.|||.||||||::|||.|.:|:|:::|::.:...
  Rat   111 ETIASLTDVTKWNHLESDGQVTILTDKTGVVQAARLLLSSVTKVLLLADQVVIKQIVTSRNKVLA 175

  Fly   137 SLEKLESVMNFTEFVRAFSVFGTEMIELAYLTGHHRNSFKEERRRAQMFSARQILEKSIAILLTS 201
            ::|:||.|.:|.|||:.||.||.||:|.|||||..:|..|:|:::|:|..||.:|||...:|||:
  Rat   176 TMERLERVNSFQEFVQIFSQFGNEMVEFAYLTGDRQNDLKDEKKKARMAVARAVLEKGTMMLLTA 240

  Fly   202 SKNSLIHSDCVIVKENRDTVFCQIRRAMDLIHFVVKDSIFDTAKHMPFEKQASNPNYENESIYTT 266
            ||..|.|..|....:|::.||.::|.|::.:..:|.|.           :...:.:..:.||:|.
  Rat   241 SKTCLRHPSCESAHKNKEGVFDRMRAALEKVIEIVTDC-----------RLNRDTDSSSVSIFTG 294

  Fly   267 IKRIVNLIKRYKYQMSYYEGSGEGNNNSDAYFSFLDDDLWKSEKNLPSAAGGGRMVNNTNFRKHL 331
            ||.:                                                  .:|....|:::
  Rat   295 IKEL--------------------------------------------------KLNMEALRENV 309

  Fly   332 SSESLDLREELSLAFEKLFEKAHDFTDSPYISHNHRKNILSYCDNCKLEFDLYLNTIMKDQHEGG 396
            ..||   :|.||.|.|.:.|:..|||||.|.||.||:.||......:.|...:::..|:.|....
  Rat   310 YFES---KENLSAALEVILERVEDFTDSAYTSHEHRERILELSAQARTEVQQFISVWMQAQSRKT 371

  Fly   397 GGAGGVGGVGGGQVKGRSDPELGMLS---SLEELCKQL---VVSVSSQIEDFNESLKICSKLVKS 455
            ..|.             .:.||.:|.   ||:||.|:|   .:.:::.:..|:..    ..::|:
  Rat   372 KSAA-------------EELELTVLKVSHSLDELRKELHCTAMQLAADLLKFHAD----HVVLKA 419

  Fly   456 FHVLATNYDIDNLNQRSSKFHDCCDHIFDICKLLQHIAPTERLQVQAKCLAINLRIYGPQVFIAA 520
            ..|.....:::.|.:.:.|..:..:.:.:.|:||:|::.||.|::.........::.|.|:..||
  Rat   420 LKVTGVEGNLEALAEYACKLSEQKEQLVETCRLLRHVSGTEPLEITCMHAEETFQVTGQQIISAA 484

  Fly   521 KILWKYSNSSAANENFESFSDMWKWLTNEISMIAKKILVSINTTKGDR----DADAEKCESSSDK 581
            :.|..:.:|..|.||.:.|.:.|:...::::.:.::|.......:|::    ........:::.|
  Rat   485 ETLTLHPSSKIAKENLDVFCEAWESQISDLATLLREISDVFEGRRGEKYDHLSLPKPMKNNANLK 549

  Fly   582 LTKSGVPATEDGEMVEYSGLE-GKNNGDLNTYQSKWSEDLSDDNDILKRAKNMSAMAFLMYQFTK 645
            ..||..|.:|:...:...||: |..:.|.:....||.:   |||:|::..:|||.||:.:|.||:
  Rat   550 SVKSDKPDSEEQAKIAKLGLKLGLLSSDADCEIEKWED---DDNEIVRHGRNMSRMAYSLYLFTR 611

  Fly   646 GNGSLRTTQDLFTQAEYFAEEANRLYKVLRHFSYQVPASDNKKDLLNILDRVPTFVQALQFTVKD 710
            |.|.|:|:|||....|.||.|..:|...::.||.|:...|....||.|...:|...| ||...|
  Rat   612 GEGPLKTSQDLIHFLEVFATEGLKLTSSIQSFSKQLKDDDKLMLLLEINKLIPLCHQ-LQTITK- 674

  Fly   711 HTVGKAATFVKVDHVIRETKNLMNVINKVVSKCFECATK 749
             |..::..|:|||..:.:.:::|.::.:::|.|::...|
  Rat   675 -TSLQSKVFLKVDKCVTKIRSMMTLVVQLLSLCYKLLKK 712

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Catr	NP_726389.4	Vinculin	38..755	CDD:460040	205/723 (28%)
Ctnnal1	NP_001100119.1	Vinculin	30..674	CDD:460040	200/712 (28%)