Protein Alignment alpha-Catr and Vcl

DIOPT Version :10

• Sequence 1: NP_726389.4
• Gene: alpha-Catr / 49713
• FlyBaseID: FBgn0029105
• Length: 810
• Species: Drosophila melanogaster
• Sequence 2: XP_006518985.1
• Gene: Vcl / 22330
• MGIID: 98927
• Length: 1134
• Species: Mus musculus
• Alignment Length: 1131
• Identity: 170/1131 - (15%)
• Similarity: 321/1131 - (28%)
• Gaps: 467/1131 - (41%)

  Fly    38 AVERFITIGEIIAEENID--IKGDMYEAAKEARDAGKSIERLCDISPLSGMELRHHIEPLKDYGA 100
            ||...:.:|:...:...|  :|.||..|..:..:|...:.:...:     ::...:..|.:||
Mouse    50 AVSNLVRVGKETVQTTEDQILKRDMPPAFIKVENACTKLVQAAQM-----LQSDPYSVPARDY-- 107

  Fly   101 IILAARSLLSSVTRILLLVDIIVVKKLLTAKKRASESLEKLESVMNFTEFVRAFSVFGTEMIELA 165
            :|..:|.:||..:.:||..|...|:|::...|...|.|...|.|....:.|......|..|.::|
Mouse   108 LIDGSRGILSGTSDLLLTFDEAEVRKIIRVCKGILEYLTVAEVVETMEDLVTYTKNLGPGMTKMA 172

  Fly   166 YLTGHHRNSFKEERRRAQMFSARQILEKSIAILLTSSKNSLIHSDCVIVKENRDTVFCQIRRAMD 230
            .:....:.....:..|..:.::...:::.:.:|:::.|
Mouse   173 KMIDERQQELTHQEHRVMLVNSMNTVKELLPVLISAMK--------------------------- 210

  Fly   231 LIHFVVKDSIFDTAKHMPFEKQASNPNYENESIYTTIKRIVNLIKRYKYQMSYYEGSGEGNNNSD 295
             |....|:|     |:...|:...|.|:..|.:...|..|:.::     |::.::.....:.:::
Mouse   211 -IFVTTKNS-----KNQGIEEALKNRNFTVEKMSAEINEIIRVL-----QLTSWDEDAWASKDTE 264

  Fly   296 AY---FSFLDDDL-----WKSEKNL-PSAAG------------------GGR----MVNNTNFRK 329
            |.   .:.:|..|     |..:.|. |..||                  .|:    ::.......
Mouse   265 AMKRALASIDSKLNQAKGWLRDPNASPGDAGEQAIRQILDEAGKVGELCAGKERREILGTCKMLG 329

  Fly   330 HLSSESLDLR---------------------EELSLAFEKLFEKAHDFTDSPY-------ISHN- 365
            .::.:..|||                     :.|:...|....|....|:|..       .:.|
Mouse   330 QMTDQVADLRARGQGASPVAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKIDAAQNW 394

  Fly   366 -------------------HRKNILSYCDNCKLEFDLY--------LNTIMKDQHEGGGG----- 398
                               ..:.|...||:.|...|:.        |.:.:.|....|.|
Mouse   395 LADPNGGPEGEEQIRGALAEARKIAELCDDPKERDDILRSLGEIAALTSKLGDLRRQGKGDSPEA 459

  Fly   399 ----------------------------------AGGV--------------GGVGGGQVKG--- 412
                                              .|.:              .|||...::|
Mouse   460 RALAKQVATALQNLQTKTNRAVANSRPAKAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVA 524

  Fly   413 -------------RSDPELGMLSSLEELCKQL-------------VVSVSSQIEDFNESLKI--- 448
                         |.| .|.....:::|..||             ..:::||::|..:.||.
Mouse   525 EGHRLANVMMGPYRQD-LLAKCDRVDQLTAQLADLAARGEGESPQARALASQLQDSLKDLKAQMQ 588

  Fly   449 -------------CSKLVKSFHVLAT-NYDIDN----LNQRSSKFHDCCDHIFDICKLLQHI--- 492
                         .:..:|...|.|| ..|..|    .::|::.|.:....:....:....:
Mouse   589 EAMTQEVSDVFSDTTTPIKLLAVAATAPPDAPNREEVFDERAANFENHSGRLGATAEKAAAVGTA 653

  Fly   493 --APTERLQVQAKCLAINLRIYGPQVFIAAKILWKYSNSSAANENFESFSDMW------------ 543
              :..|.:|...|    ..|...|||..||:||.:...:.||.|:||:..:.|
Mouse   654 NKSTVEGIQASVK----TARELTPQVISAARILLRNPGNQAAYEHFETMKNQWIDNVEKMTGLVD 714

  Fly   544 --------------------------------KWLTNEISMIAKK----ILVSINTTKGDRDAD- 571
                                            :.|....:.||::    :||:....:...|..
Mouse   715 EAIDTKSLLDASEEAIKKDLDKCKVAMANIQPQMLVAGATSIARRANRILLVAKREVENSEDPKF 779

  Fly   572 AEKCESSSDKLTK---------------------------SGV---------------------- 587
            .|..:::||:|:|                           ||.
Mouse   780 REAVKAASDELSKTISPMVMDAKAVAGNISDPGLQKSFLDSGYRILGAVAKVREAFQPQEPDFPP 844

  Fly   588 ---------------------------------PATEDGEMVEYSGLEGKNN------GDLNTYQ 613
                                             |..:|.|..|....|..|.      ..|:...
Mouse   845 PPPDLEQLRLTDELAPPKPPLPEGEVPPPRPPPPEEKDEEFPEQKAGEVINQPMMMAARQLHDEA 909

  Fly   614 SKWS-----------------------------EDLSDD-------------------------- 623
            .|||                             .|:.||
Mouse   910 RKWSSKPGIPAAQVGIGVVAEANAADAVGFPFPSDMEDDYEPELLLMPSNQPVNQPILAAAQSLH 974

  Fly   624 ----------NDILKRAKNMSAMAFLMYQFTKGNGSLRTTQDLFTQAEYFAEEANRLYKVLRHFS 678
                      |||:..||.|:.:...|.:..:|...  |.:.|...|:..|:.::.:.::.:..:
Mouse   975 REATKWSSKGNDIIAAAKRMALLMAEMSRLVRGGSG--TKRALIQCAKDIAKASDEVTRLAKEVA 1037

  Fly   679 YQVPASDNKKDLLNILDRVPTFVQALQF--TVKDHTVGKA---------ATFVKVDHVIRETKNL 732
            .|......:.:||.:.:|:||....|:.  |||...:|:.         ||    :.::...:||
Mouse  1038 KQCTDKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNISDEESEQAT----EMLVHNAQNL 1098

  Fly   733 MNVINKVVSKCFECATKYKLNLTGIT 758
            |..:.:.|.:....:.|.:.: .|.|
Mouse  1099 MQSVKETVREAEAASIKIRTD-AGFT 1123

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Catr	NP_726389.4	Vinculin	38..755	CDD:460040	168/1126 (15%)
Vcl	XP_006518985.1	Vinculin	3..1134	CDD:460040	170/1131 (15%)