DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Catr and ctn-1

DIOPT Version :9

Sequence 1:	NP_726389.4	Gene:	alpha-Catr / 49713	FlyBaseID:	FBgn0029105	Length:	810	Species:	Drosophila melanogaster
Sequence 2:	NP_001364770.1	Gene:	ctn-1 / 171818	WormBaseID:	WBGene00000832	Length:	812	Species:	Caenorhabditis elegans

Alignment Length:	809	Identity:	276/809 - (34%)
Similarity:	409/809 - (50%)	Gaps:	128/809 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 NEQIMSTFGNIGHLLNIAVERFITIGEIIAEENIDIKGDMYEAAKEARDAGKSIERL---CDISP 82
            :|:.|.....||..:..|:|||:.:||.||:||.||:.:||:|..|||.||.|:..|   |:..|
Worm    83 SERAMRAALKIGSAVEAAIERFVCVGETIADENADIQPEMYDACTEARLAGASMANLSCACNDDP 147

  Fly    83 LSGMELRHHIEPLKDYGAIILAARSLLSSVTRILLLVDIIVVKKLLTAKKRASESLEKLESVMNF 147
            .|          :.|...::.|:|.|||||||:|||.|.::||::|.|:.:.:.||.:|||..:|
Worm   148 NS----------VVDKAVLVRASRQLLSSVTRVLLLADRVLVKQVLRAEDKIAFSLSRLESTRSF 202

  Fly   148 TEFVRAFSVFGTEMIELAYLTGHHRNSFKEERRRAQMFSARQILEKSIAILLTSSKNSLIHSDCV 212
            .:||:.|:|||.||:|||:.:|..::..|.|:|:|||..||..||:...:|||:||..|.|.||.
Worm   203 NDFVKVFAVFGGEMVELAHRSGDRQHDLKSEKRKAQMSIARTSLERLTMLLLTASKTYLRHPDCD 267

  Fly   213 IVKENRDTVFCQIRRAMDLIHFVVKDSIFDTAKHMPFEKQASNP---------NYENESIYTTIK 268
            ...:.||.||.|::.:::||...|.|.|..|.|....:.:...|         |       ..||
Worm   268 SALQCRDGVFYQMKLSLELIAICVCDGILTTEKSRYIQDEPDMPIDIALQLTAN-------AAIK 325

  Fly   269 RIVNLIKRYKYQMSYYEGSGEGNNNSDAYFSFLDDDLWKSEKNLPSAAGGGRMVNNTNFRKHLSS 333
            ::..:::..:  |:...|:|
Worm   326 QLTEMLEMIR--MTVRVGAG--------------------------------------------- 343

  Fly   334 ESLDLREELSLAFEKLFEKAHDFTDSPYISHNHRKNILSYCDNCKLEFDLYLNTIMKDQHEGGGG 398
                :||.:..|.:.|.:...|||||.|..|:.|:.||.:.:.|:.|.   .|.|..|::|....
Worm   344 ----VRERIVSALDALCQLTQDFTDSAYTPHHQREQILDFLEECRFEM---TNLIQPDENEQLAA 401

  Fly   399 AGGVGGVGGGQVKGRSDPELGMLS-SLEELCKQLVVSVSSQIEDF---NESLKICSKLVKSFHVL 459
            :|             .:..:..|: .|::|.|||.:....||.:.   ||.    ..|:.|....
Worm   402 SG-------------LEVTVERLNRRLKDLSKQLQIVAMEQISEVLRANED----QVLLSSMKAC 449

  Fly   460 ATNYDIDNLNQRSSKFHDCCDHIFDICKLLQHIAPTERLQVQAKCLAINLRIYGPQVFIAAKILW 524
            |.:.|||.:.:...||.:..||:.::|:||.||:.|:.|.|....:..|:|...|...:|.:.|.
Worm   450 AVSGDIDGVEKYMHKFREHADHMQEVCRLLHHISITDALHVHTGHVERNMRALAPLTILAGRTLC 514

  Fly   525 KYSNSSAANENFESFSDMWKWLTNEISMIAKKILVSINTTKGDRDADAEKCESSSDKLTKSGV-- 587
            .:.:|..|.||.|.|.|.|....|::|.:||:..|:.|    .|.|..::...|..:..|.|.
Worm   515 VHPSSRIARENLEVFCDTWGQAVNDLSRVAKESDVAAN----GRVAAEKQAYMSLPRPGKHGTTQ 575

  Fly   588 ----PAT---EDGEMVEYSGLEGK-NNGDLNTYQSKWSEDLSDDNDILKRAKNMSAMAFLMYQFT 644
                |.|   ||.:.:...|||.| ...:::....||.|  ..:|||:||||.||:||:.||.||
Worm   576 KPSKPITLDVEDQQKMAKVGLEMKLLTSEVDAEAEKWDE--YAENDIVKRAKAMSSMAYNMYLFT 638

  Fly   645 KGNGSLRTTQDLFTQAEYFAEEANRLYKVLRHFSYQVPASDNKKDLLNILDRVPTFVQALQFTVK 709
            :|:|.|:||.|||||||:|||:||::|:.:|.|||:||.|..|.||..||:|:|...|.||..||
Worm   639 RGDGPLKTTHDLFTQAEFFAEQANQMYRTVREFSYEVPGSAEKSDLSAILERIPLHCQQLQVMVK 703

  Fly   710 DHTVGKAATFVKVDHVIRETKNLMNVINKVVSKCFECATK-YKLNLTGITGGLTSERSNENMAGG 773
            ..||||.|||.|||.||:|||||||.|.|:|:..|.|||| ::.:..|:........|   |.|.
Worm   704 SPTVGKTATFGKVDSVIQETKNLMNEIAKLVTASFVCATKMFQDSQQGMKSSFAEVLS---MGGR 765

  Fly   774 MCDSKGTTSSSDIPXHYGMARRAKGDARR 802
            :...||..::    ..:|...:|..:.||
Worm   766 VPTVKGQVAN----RLFGAGHQASDEPRR 790

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Catr	NP_726389.4	Vinculin	52..755	CDD:279395	254/729 (35%)
ctn-1	NP_001364770.1	Vinculin	114..751	CDD:395830	254/730 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165726
Domainoid	1	1.000	160	1.000	Domainoid score	I2477
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2815
Inparanoid	1	1.050	416	1.000	Inparanoid score	I1021
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46067
OrthoDB	1	1.010	-	-		D127258at33208
OrthoFinder	1	1.000	-	-		FOG0007235
OrthoInspector	1	1.000	-	-		oto19911
orthoMCL	1	0.900	-	-		OOG6_107795
Panther	1	1.100	-	-	LDO	PTHR46342
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5795
SonicParanoid	1	1.000	-	-		X5337
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.940