Protein Alignment alpha-Catr and CTNNA1

DIOPT Version :10

• Sequence 1: NP_726389.4
• Gene: alpha-Catr / 49713
• FlyBaseID: FBgn0029105
• Length: 810
• Species: Drosophila melanogaster
• Sequence 2: NP_001894.2
• Gene: CTNNA1 / 1495
• HGNCID: 2509
• Length: 906
• Species: Homo sapiens
• Alignment Length: 946
• Identity: 195/946 - (20%)
• Similarity: 330/946 - (34%)
• Gaps: 295/946 - (31%)

  Fly    33 HLLNIAVER----FITIGEIIAEENIDIKGDMYEAAKEARDAGKSIE----RLCDISPLSGMELR 89
            |:|..:||:    |:..|:.||:|:..:|.::..|.::.|..|..::    ...| .|.|.::
Human    59 HVLAASVEQATENFLEKGDKIAKESQFLKEELVAAVEDVRKQGDLMKAAAGEFAD-DPCSSVK-- 120

  Fly    90 HHIEPLKDYGAIILAARSLLSSVTRILLLVDIIVVKKLLTAKKRASESLEKLESVMNFTEFVRAF 154
                    .|.::.|||:|||:|||:|:|.|:..|.|||...|...:.:.||.:..|..:....:
Human   121 --------RGNMVRAARALLSAVTRLLILADMADVYKLLVQLKVVEDGILKLRNAGNEQDLGIQY 177

  Fly   155 SVFGTEMIELAYLTGHHRNSFKEERRRAQMFSARQILEKSIAILLTSSKNSLIHSDCVIVKENRD 219
            .....|:.:|..:....:...|:...|.||.:||.||:|::.||.|:|:..|.|.|....|.|||
Human   178 KALKPEVDKLNIMAAKRQQELKDVGHRDQMAAARGILQKNVPILYTASQACLQHPDVAAYKANRD 242

  Fly   220 TVFCQIRRAMDLIHFVVKDSIFDTAKHMPFEKQASNPNYENESIYTTIKRIVNLIKRYKYQMSYY 284
            .::.|:::|:..|....:.:..|.|                                     |.:
Human   243 LIYKQLQQAVTGISNAAQATASDDA-------------------------------------SQH 270

  Fly   285 EGSGEGNNNSDAYFSFLDDDLWKSEKNLPSAAGGGRMVNNTNFRKHLSSESLDLREE-----LSL 344
            :|.|                            ||.......||.|.:..:.|...||     |..
Human   271 QGGG----------------------------GGELAYALNNFDKQIIVDPLSFSEERFRPSLEE 307

  Fly   345 AFEKLFEKAHDFTDSPYISHNHRKNILSYCDNCKLEFDLYLNTIMKDQHEGGGGAGGVGGVGGGQ 409
            ..|.:...|....||.....:.|:.|::.|:..:......|:..|       |.||.
Human   308 RLESIISGAALMADSSCTRDDRRERIVAECNAVRQALQDLLSEYM-------GNAGR-------- 357

  Fly   410 VKGRSDPELGMLSSLEELCK-------QLVVSVSSQIED-FNESLKICSKLVKSFHVLATNYDID 466
             |.|||   .:.|:::::.|       ||..:|...:.| |.|:......|:::    |.|.:..
Human   358 -KERSD---ALNSAIDKMTKKTRDLRRQLRKAVMDHVSDSFLETNVPLLVLIEA----AKNGNEK 414

  Fly   467 NLNQRSSKFHDCCDHIFDICKLLQHIAPTERLQVQAKCLAINLRIYGPQVFIAAKILWKYSNSSA 531
            .:.:.:..|.:..:.:.::..|...|:..|......:..|..|....|||..||..|.....|..
Human   415 EVKEYAQVFREHANKLIEVANLACSISNNEEGVKLVRMSASQLEALCPQVINAALALAAKPQSKL 479

  Fly   532 ANENFESFSDMW----KWLT---NEISMIAKKILVSINTTKGD----------RDAD-------- 571
            |.||.:.|.:.|    :.||   ::|:.|...:.||.|....|          :|.|
Human   480 AQENMDLFKEQWEKQVRVLTDAVDDITSIDDFLAVSENHILEDVNKCVIALQEKDVDGLDRTAGA 544

  Fly   572 -------------------------------------------AEKCESSSDKLTKSGVPATEDG 593
                                                       .|:.|::.:.|:.......::.
Human   545 IRGRAARVIHVVTSEMDNYEPGVYTEKVLEATKLLSNTVMPRFTEQVEAAVEALSSDPAQPMDEN 609

  Fly   594 EMVE-----YSGL-------------EGKNNGDLNT----YQSKWSEDLSDD------------- 623
            |.::     |.|:             |..::.|..|    .:|:.|....||
Human   610 EFIDASRLVYDGIRDIRKAVLMIRTPEELDDSDFETEDFDVRSRTSVQTEDDQLIAGQSARAIMA 674

  Fly   624 -----------------------------------NDILKRAKNMSAMAFLMYQFTKGNGSLRTT 653
                                               |||:..||.|..:...|..||:|.|.|:.|
Human   675 QLPQEQKAKIAEQVASFQEEKSKLDAEVSKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNT 739

  Fly   654 QDLFTQAEYFAEEANRLYKVLRHFSYQVPASDNKKDLLNILDRVPTFVQALQFTVK----DHTVG 714
            .|:.:.|:..||..:|:.|:.|..:...|.|..|:|||..|.|:..:...|....|    ...:|
Human   740 SDVISAAKKIAEAGSRMDKLGRTIADHCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLG 804

  Fly   715 KAATFVKVD---HVIRETKNLMNVINKVVSKCFECATKYK-------LNLTGITGGLTSERSNEN 769
            .......||   .:|:..|||||.:.:.|...:..:|||:       |||..::..:.:
Human   805 GELVVSGVDSAMSLIQAAKNLMNAVVQTVKASYVASTKYQKSQGMASLNLPAVSWKMKA------ 863

  Fly   770 MAGGMCDSKGTTSSSDIPXHYGMARRAKGDARRTRV 805
                             |....:.:|.|.|..:|::
Human   864 -----------------PEKKPLVKREKQDETQTKI 882

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Catr	NP_726389.4	Vinculin	38..755	CDD:460040	187/889 (21%)
CTNNA1	NP_001894.2	Involved in homodimerization	2..228		52/179 (29%)
		Vinculin	19..867	CDD:460040	191/929 (21%)
		Interaction with JUP and CTNNB1. /evidence=ECO:0000269|PubMed:9152027	97..148		18/61 (30%)
		Interaction with alpha-actinin	325..394		18/87 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	864..894		5/19 (26%)