Protein Alignment alpha-Catr and Ctnna1

DIOPT Version :10

• Sequence 1: NP_726389.4
• Gene: alpha-Catr / 49713
• FlyBaseID: FBgn0029105
• Length: 810
• Species: Drosophila melanogaster
• Sequence 2: NP_033948.1
• Gene: Ctnna1 / 12385
• MGIID: 88274
• Length: 906
• Species: Mus musculus
• Alignment Length: 945
• Identity: 195/945 - (20%)
• Similarity: 329/945 - (34%)
• Gaps: 293/945 - (31%)

  Fly    33 HLLNIAVER----FITIGEIIAEENIDIKGDMYEAAKEARDAG---KSIERLCDISPLSGMELRH 90
            |:|..:||:    |:..|:.||:|:..:|.::..|.::.|..|   ||........|.|.::
Mouse    59 HVLAASVEQATENFLEKGDKIAKESQFLKEELVVAVEDVRKQGDLMKSAAGEFADDPCSSVK--- 120

  Fly    91 HIEPLKDYGAIILAARSLLSSVTRILLLVDIIVVKKLLTAKKRASESLEKLESVMNFTEFVRAFS 155
                   .|.::.|||:|||:|||:|:|.|:..|.|||...|...:.:.||.:..|..:....:.
Mouse   121 -------RGNMVRAARALLSAVTRLLILADMADVYKLLVQLKVVEDGILKLRNAGNEQDLGIQYK 178

  Fly   156 VFGTEMIELAYLTGHHRNSFKEERRRAQMFSARQILEKSIAILLTSSKNSLIHSDCVIVKENRDT 220
            ....|:.:|..:....:...|:...|.||.:||.||:|::.||.|:|:..|.|.|....|.|||.
Mouse   179 ALKPEVDKLNIMAAKRQQELKDVGNRDQMAAARGILQKNVPILYTASQACLQHPDVAAYKANRDL 243

  Fly   221 VFCQIRRAMDLIHFVVKDSIFDTAKHMPFEKQASNPNYENESIYTTIKRIVNLIKRYKYQMSYYE 285
            ::.|:::|:..|
Mouse   244 IYKQLQQAVTGI----------------------------------------------------- 255

  Fly   286 GSGEGNNNSDAYFSFLDDDLWKSEKNLPSAAGGGRMVNNTNFRKHLSSESLDLREE-----LSLA 345
                    |:|..:...||..:.:    ..:||.......||.|.:..:.|...||     |...
Mouse   256 --------SNAAQATASDDAAQHQ----GGSGGELAYALNNFDKQIIVDPLSFSEERFRPSLEER 308

  Fly   346 FEKLFEKAHDFTDSPYISHNHRKNILSYCDNCKLEFDLYLNTIMKDQHEGGGGAGGVGGVGGGQV 410
            .|.:...|....||.....:.|:.|::.|:..:......|:..|       |.||.
Mouse   309 LESIISGAALMADSSCTRDDRRERIVAECNAVRQALQDLLSEYM-------GNAGR--------- 357

  Fly   411 KGRSDPELGMLSSLEELCK-------QLVVSVSSQIED-FNESLKICSKLVKSFHVLATNYDIDN 467
            |.|||   .:.|:::::.|       ||..:|...:.| |.|:......|:::    |.|.:...
Mouse   358 KERSD---ALNSAIDKMTKKTRDLRRQLRKAVMDHVSDSFLETNVPLLVLIEA----AKNGNEKE 415

  Fly   468 LNQRSSKFHDCCDHIFDICKLLQHIAPTERLQVQAKCLAINLRIYGPQVFIAAKILWKYSNSSAA 532
            :.:.:..|.:..:.:.::..|...|:..|......:..|..|....|||..||..|.....|..|
Mouse   416 VKEYAQVFREHANKLIEVANLACSISNNEEGVKLVRMSASQLEALCPQVINAALALAAKPQSKLA 480

  Fly   533 NENFESFSDMW----KWLT---NEISMIAKKILVSINTTKGD----------RDAD--------- 571
            .||.:.|.:.|    :.||   ::|:.|...:.||.|....|          :|.|
Mouse   481 QENMDLFKEQWEKQVRVLTDAVDDITSIDDFLAVSENHILEDVNKCVIALQEKDVDGLDRTAGAI 545

  Fly   572 ------------------------------------------AEKCESSSDKLTKSGVPATEDGE 594
                                                      .|:.|::.:.|:.......::.|
Mouse   546 RGRAARVIHVVTSEMDNYEPGVYTEKVLEATKLLSNTVMPRFTEQVEAAVEALSSDPAQPMDENE 610

  Fly   595 MVE-----YSGL-------------EGKNNGDLNT----YQSKWSEDLSDD-------------- 623
            .::     |.|:             |..::.|..|    .:|:.|....||
Mouse   611 FIDASRLVYDGIRDIRKAVLMIRTPEELDDSDFETEDFDVRSRTSVQTEDDQLIAGQSARAIMAQ 675

  Fly   624 ----------------------------------NDILKRAKNMSAMAFLMYQFTKGNGSLRTTQ 654
                                              |||:..||.|..:...|..||:|.|.|:.|.
Mouse   676 LPQEQKAKIAEQVASFQEEKSKLDAEVSKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTS 740

  Fly   655 DLFTQAEYFAEEANRLYKVLRHFSYQVPASDNKKDLLNILDRVPTFVQALQFTVK----DHTVGK 715
            |:.:.|:..||..:|:.|:.|..:...|.|..|:|||..|.|:..:...|....|    ...:|.
Mouse   741 DVISAAKKIAEAGSRMDKLGRTIADHCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGG 805

  Fly   716 AATFVKVD---HVIRETKNLMNVINKVVSKCFECATKYK-------LNLTGITGGLTSERSNENM 770
            ......||   .:|:..|||||.:.:.|...:..:|||:       |||..::..:.:
Mouse   806 ELVVSGVDSAMSLIQAAKNLMNAVVQTVKASYVASTKYQKSQGMASLNLPAVSWKMKA------- 863

  Fly   771 AGGMCDSKGTTSSSDIPXHYGMARRAKGDARRTRV 805
                            |....:.:|.|.|..:|::
Mouse   864 ----------------PEKKPLVKREKQDETQTKI 882

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Catr	NP_726389.4	Vinculin	38..755	CDD:460040	187/888 (21%)
Ctnna1	NP_033948.1	Involved in homodimerization. /evidence=ECO:0000250	2..228		53/178 (30%)
		Vinculin	19..867	CDD:460040	191/928 (21%)
		Interaction with JUP and CTNNB1. /evidence=ECO:0000250	97..148		19/60 (32%)
		Interaction with alpha-actinin. /evidence=ECO:0000250	325..394		18/87 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	864..894		5/19 (26%)