Protein Alignment SERCA and ATP1A4

DIOPT Version :10

• Sequence 1: NP_726381.1
• Gene: SERCA / 49297
• FlyBaseID: FBgn0263006
• Length: 1020
• Species: Drosophila melanogaster
• Sequence 2: NP_653300.2
• Gene: ATP1A4 / 480
• HGNCID: 14073
• Length: 1029
• Species: Homo sapiens
• Alignment Length: 1062
• Identity: 311/1062 - (29%)
• Similarity: 510/1062 - (48%)
• Gaps: 160/1062 - (15%)

  Fly     3 DGHSKTVEQSLNFFGTDPERGLTLDQIKANQKKYGPNELPTEEGKSIWQLVLEQFDDLLVKILLL 67
            |.|..|:|:....:..|..:|.:..:.|....:.|||.:........|....:|.......:|..
Human    50 DDHKLTLEELSTKYSVDLTKGHSHQRAKEILTRGGPNTVTPPPTTPEWVKFCKQLFGGFSLLLWT 114

  Fly    68 AAIISFV---LALFEEHEETFTAFVEPLVILLILIANAVVGVWQERNAESAIEALKEYEPEMGKV 129
            .||:.||   :.::...|.|.......:|:.:::|.......:||..:...:|:.|...|:...|
Human   115 GAILCFVAYSIQIYFNEEPTKDNLYLSIVLSVVVIVTGCFSYYQEAKSSKIMESFKNMVPQQALV 179

  Fly   130 VRQDKSGIQKVRAKEIVPGDLVEVSVGDKIPADIRITHIYSTTLRIDQSILTGESVSVIKHTDAI 194
            :|..:.  .::..:|:|.|||||:..||::|||:|:  |.:...::|.|.|||||
Human   180 IRGGEK--MQINVQEVVLGDLVEIKGGDRVPADLRL--ISAQGCKVDNSSLTGES---------- 230

  Fly   195 PDPRAVNQD--------KKNILFSGTNVAAGKARGVVIGTGLSTAIGKIRTEMSETEEIKTPLQQ 251
             :|::.:.|        .:||.|..||...|.|||:||.||.||.:|:|.:..|.....:||:..
Human   231 -EPQSRSPDFTHENPLETRNICFFSTNCVEGTARGIVIATGDSTVMGRIASLTSGLAVGQTPIAA 294

  Fly   252 KLDEFGEQLSKVISVICVAVWAINIGHFNDPAHGGSWIKGAIYYFKIAVALAVAAIPEGLPAVIT 316
            :::.|...::.|...:.|..:|:::      ..|..|::..|:    .:.:.||.:||||.|.:|
Human   295 EIEHFIHLITVVAVFLGVTFFALSL------LLGYGWLEAIIF----LIGIIVANVPEGLLATVT 349

  Fly   317 TCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFIFDKVEGNDSSFLE 381
            .||.|..:|||:||.:|::|.:|||||.||.||||||||||.|:|:|:.|:
Human   350 VCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMW-------------- 400

  Fly   382 FEMT----GSTYEPIGEVFLNGQRIKAADYDTLQELSTICIMCNDSAIDYNE-----FKQAFEKV 437
            |:||    .:|.|..|:.|....       ||...|:.|..:||.:....|:     .|:|  ..
Human   401 FDMTVYEADTTEEQTGKTFTKSS-------DTWFMLARIAGLCNRADFKANQEILPIAKRA--TT 456

  Fly   438 GEATETALIVLAEKLNSFSVNKSGLDRRSAAIACRGEIETKWKKEFTLEFSRDRKSMSSYCTPLK 502
            |:|:|:||:...|:  |:|           ::|   |:..|..|...:.|:...|...|......
Human   457 GDASESALLKFIEQ--SYS-----------SVA---EMREKNPKVAEIPFNSTNKYQMSIHLRED 505

  Fly   503 ASRLGTGPKLFVKGAPEGVLERCTHARVGTTKVPLTSALKAKILALTGQY----GTGRDTLRCLA 563
            :|:...   |.:|||||.:||.|:...:...:..:...:|.   |....|    |.|...|....
Human   506 SSQTHV---LMMKGAPERILEFCSTFLLNGQEYSMNDEMKE---AFQNAYLELGGLGERVLGFCF 564

  Fly   564 LAVADS-----PMKPDE----MDLGDSTKFYQYEVNLTFVGVVGMLDPPRKEVFDSIVRCRAAGI 619
            |.:..|     |...||    ||            ||.|||::.|:||||..|.|::.:||:|||
Human   565 LNLPSSFSKGFPFNTDEINFPMD------------NLCFVGLISMIDPPRAAVPDAVSKCRSAGI 617

  Fly   620 RVIVITGDNKATAEAICRRIGVFAEDEDTTGKSYS--------------------GREFDDLSPT 664
            :||::|||:..||:||.:.:|:.:|..:|..:..:                    |.|..|:. :
Human   618 KVIMVTGDHPITAKAIAKGVGIISEGTETAEEVAARLKIPISKVDASAAKAIVVHGAELKDIQ-S 681

  Fly   665 EQKAAVARSR---LFSRVEPQHKSKIVEFLQSMNEISAMTGDGVNDAPALKKAEIGIAMG-SGTA 725
            :|...:.::.   :|:|..||.|..|||..|.:..:.|:|||||||:||||||:|||||| ||:.
Human   682 KQLDQILQNHPEIVFARTSPQQKLIIVEGCQRLGAVVAVTGDGVNDSPALKKADIGIAMGISGSD 746

  Fly   726 VAKSAAEMVLADDNFSSIVSAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAALGLPEALIPV 790
            |:|.||:|:|.||||:|||:.|||||.|::|:|:.|.|.::|||.|:....:...||:|..|..:
Human   747 VSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIMYTLTSNIPEITPFLMFIILGIPLPLGTI 811

  Fly   791 QLLWVNLVTDGLPATALGFNPPDLDIMEKPPR--KADEGLISGWLFFRYMAIGFYVGAATVGAAA 853
            .:|.::|.||.:||.:|.:...:.|||::.||  |.|..:....:...|..||..  .|..|...
Human   812 TILCIDLGTDMVPAISLAYESAESDIMKRLPRNPKTDNLVNHRLIGMAYGQIGMI--QALAGFFT 874

  Fly   854 WWFVFSDEGPK-------LSYWQLTHHLSCL--GGGDEFKGVDCKI--FSDPHAMTMALSVLVTI 907
            ::.:.::.|.:       ..:|: ..:|:.|  ..|.::.....|:  |:   ..|.....:|.:
Human   875 YFVILAENGFRPVDLLGIRLHWE-DKYLNDLEDSYGQQWTYEQRKVVEFT---CQTAFFVTIVVV 935

  Fly   908 EMLNAMNSLSENQSLITMPPWCNLWLIGSMALSFTLHFVILYVDVLSTVFQVTPLSAEEWITVMK 972
            :..:.:.|.:...||........:.:.|.:..:....| :.|...:....::.||....|:..:.
Human   936 QWADLIISKTRRNSLFQQGMRNKVLIFGILEETLLAAF-LSYTPGMDVALRMYPLKITWWLCAIP 999

  Fly   973 FSIPVVLLDETLKFVARKIADG 994
            :||.:.:.||..|.:.|:..||
Human  1000 YSILIFVYDEIRKLLIRQHPDG 1021

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SERCA	NP_726381.1	P-type_ATPase_SERCA	5..989	CDD:319778	307/1053 (29%)
ATP1A4	NP_653300.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..37
		P-type_ATPase_Na-K_like	70..1026	CDD:319794	306/1042 (29%)
		Interaction with phosphoinositide-3 kinase. /evidence=ECO:0000250	90..92		0/1 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	223..242		8/29 (28%)