DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp303a1 and cyp2ad6

DIOPT Version :9

Sequence 1:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_001076405.1	Gene:	cyp2ad6 / 799957	ZFINID:	ZDB-GENE-041001-157	Length:	492	Species:	Danio rerio

Alignment Length:	502	Identity:	139/502 - (27%)
Similarity:	233/502 - (46%)	Gaps:	41/502 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 WIFCATLLAILFGGVR--KPKRFPPGPAWYPIVGSALQVSQLRCRLGMFCKVIDVFARQYVNPYG 69
            |:|....|.:|...:|  .|..|||||...||:|:..        ..:..|.:|    |.:..||
Zfish    15 WLFLTCFLLLLIDLIRNKNPANFPPGPWPLPILGNVF--------TDVNYKTVD----QLIEKYG 67

  Fly    70 -FYGLKIGKDKVVIAYTNDAISEMM--TNEDIDGRPDGIFYRLRTFNSRLGVLLTDGEMWVEQRR 131
             .:.::||.||:|.......:.:::  ..|:...||....:  .|.....|:...:|..|.:.::
Zfish    68 NIFSVRIGSDKIVYVSGFKMVKDVLITQGENFTDRPVSPLF--DTLYKGRGLSFNNGYSWRKHQQ 130

  Fly   132 FILRHLKNFGFARSGMMDIVHNEATCLLQDLKDKVLKSGGKQTRIEMHD-LTSV--YVLNTLWCM 193
            |.:.||||||..|..:.:  :|:..|..       |....|:.:....| |..:  .|.|.:..:
Zfish   131 FSMSHLKNFGEGRKTLEE--NNQRECYF-------LCGAFKEEQGRPFDPLVKINNAVANVIGFL 186

  Fly   194 LSGRRYEPGSPEITQLLETFFE-LFKNIDMVGALFSHFP-LLRFIAPNFSGYNGFVESHRSLYTF 256
            :.|.|||.......:.|:...| :|....:...|:..|| :::::.   ..:...:.:::.|..|
Zfish   187 VFGHRYEYSDVNFQKRLQMSAESVFLTGSVWNQLYDAFPGIMKWVP---GPHQTIISNYQKLANF 248

  Fly   257 MSKEIELHRLTYKNYDEPRDLMDSYL-RAQDEGNDEKGMFSDQSLLAICLDMFLAGSETTNKSLG 320
            :.::||.|:..: :...|||.:|:|| .|:.:.||.:..|:..||:...:|:|..|:|||..:|.
Zfish   249 LEEKIEQHKPDW-DISNPRDYIDAYLTEAEKKKNDTEAGFTVGSLVWSMVDLFEGGTETTTNTLR 312

  Fly   321 FCFMHLVLQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVRMFMLHTFGIPHRAV 385
            :..:.|:..|:||::...||.||:| .|:|..| |:..:.|..|...|.:|...|....:...|.
Zfish   313 WALLFLIKYPDIQKKVQAEIDEVIG-SRLPSMS-DKANMHYLNAFIHEVLRRANLVPLNMARVAK 375

  Fly   386 CDTRLSGYEIPKDTMVIACFRGMLINPVDFPDPESFNPDRYL-FDGHLKLPEAFNPFGFGRHRCM 449
            .||.|.||.|.|.|::|.....:|.:..::..|::|||..:| .:||.....||..|..|:.:|.
Zfish   376 KDTTLGGYFITKGTVMITNLTSVLYDKQEWETPDAFNPKHFLDSEGHFCRRNAFFAFSAGKRQCP 440

  Fly   450 GDLLGRQNLFMFTTTVLQNFKMVAIPGQVPEEVPLEGATAAVKPYDI 496
            |:.|....||:|.|.:||.|......|:.|......|.|.|..||.|
Zfish   441 GEYLAHLELFIFLTILLQTFSFSPPDGEEPSLDSQVGFTQAPLPYKI 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	125/461 (27%)
cyp2ad6	NP_001076405.1	p450	38..488	CDD:278495	132/479 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.010