DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp303a1 and cyp2p8

DIOPT Version :9

Sequence 1:	NP_001285977.1	Gene:	Cyp303a1 / 49165	FlyBaseID:	FBgn0001992	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_001076504.1	Gene:	cyp2p8 / 100034366	ZFINID:	ZDB-GENE-061030-1	Length:	496	Species:	Danio rerio

Alignment Length:	519	Identity:	145/519 - (27%)
Similarity:	244/519 - (47%)	Gaps:	43/519 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFYTVIWIFCATLLA-----ILFGGVRK---PKRFPPGPAWYPIVGSALQVSQLRCRLGMFCKVI 57
            ::|...||...::|.     :|.|...|   ||.|||||...||:|....:...:..| .|.|
Zfish     3 LWYLYEWIDIKSILIFLCVFLLLGDYIKNKAPKNFPPGPWSLPIIGDLHHIDNSKIHL-QFTK-- 64

  Fly    58 DVFARQYVNPYGFYGLKIGKDKVVIAYTNDAISE--MMTNEDIDGRPD-GIFYRLRTFNSRLGVL 119
              ||.:|.|.:.|   ::...::|:....:.:.|  :...:::..||. .:||.:   ....|::
Zfish    65 --FAERYGNIFSF---RLFGPRIVVLNGYNLVKEVYIKQGDNLADRPVLPLFYEI---VGDKGLI 121

  Fly   120 LTDGEMWVEQRRFILRHLKNFGFARSGMMDIVHNEATCLLQDLKDKVLKSGGK--QTRIEMHDLT 182
            |:.|..|..||||.|..|:|||..:..:...::.|...    |.:.:....|:  ..|:.:::..
Zfish   122 LSSGYKWKHQRRFALSTLRNFGLGKKSLEPSINVECGF----LNEAISNEQGRPFDPRLLLNNAV 182

  Fly   183 SVYVLNTLWCMLSGRRYEPGSPEITQLLETFFE-LFKNIDMVGALFSHFPLL--RFIAPNFSGYN 244
            |    |.:..::.|.|::........||:...| ::....:...|::.||.|  |...|    :.
Zfish   183 S----NVICVLVFGNRFDYSDHHFQTLLKNISEAVYLEGSICNQLYNMFPWLMERLPGP----HK 239

  Fly   245 GFVESHRSLYTFMSKEIELHRLTYKNYDEPRDLMDSYLRAQDEGNDEKGMFSDQSLLAIC-LDMF 308
            ..:...|.:..|:.:::..||:.| :...|||.:|.:|...::..|:.....|...|.|| ||:|
Zfish   240 TIITLWRKVTDFVREKVNEHRVDY-DPSNPRDYIDCFLTEMEKLKDDTAAGFDVENLCICSLDLF 303

  Fly   309 LAGSETTNKSLGFCFMHLVLQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVRMF 373
            :||:|||:.:|.:..::::..||||.:..:||..|||..|.|..| ||..:||..|:..|..||.
Zfish   304 VAGTETTSTTLYWGLLYMIKYPEIQAKVQEEIDAVVGGSRQPSVS-DRDNMPYTNAVIHEIQRMG 367

  Fly   374 MLHTFGIPHRAVCDTRLSGYEIPKDTMVIACFRGMLINPVDFPDPESFNPDRYL-FDGHLKLPEA 437
            .:....:......||::..|.|||.|||.:....:|.:..::..|.||||..:| .:|..:..:|
Zfish   368 NIAPINLARSTSEDTQIGNYSIPKGTMVTSNLTSVLFDESEWETPHSFNPGHFLDAEGKFRRRDA 432

  Fly   438 FNPFGFGRHRCMGDLLGRQNLFMFTTTVLQNFKMVAIPGQVPEEVPLEGATAAVKPYDIMLVAR 501
            |.||..|:..|:|:.|.|..||:|.:::||.|......|..|......|.|...||:.:..|.|
Zfish   433 FLPFSLGKRVCLGEQLARMELFLFFSSLLQRFTFSPPAGVEPSLDYKMGGTHCPKPFKLCAVPR 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	128/461 (28%)
cyp2p8	NP_001076504.1	p450	38..492	CDD:278495	133/478 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.820