Protein Alignment Mbs and ppp1r12c

DIOPT Version :10

• Sequence 1: NP_001246786.1
• Gene: Mbs / 49070
• FlyBaseID: FBgn0005536
• Length: 1273
• Species: Drosophila melanogaster
• Sequence 2: NP_001071047.1
• Gene: ppp1r12c / 570218
• ZFINID: ZDB-GENE-010724-11
• Length: 672
• Species: Danio rerio
• Alignment Length: 1301
• Identity: 272/1301 - (20%)
• Similarity: 412/1301 - (31%)
• Gaps: 667/1301 - (51%)

  Fly     9 NSAMMKRAEQLKRWEESDTNRAAPTPRH-----------EHGR------------RIKFSSGCVF 50
            ::|:.||.|||.||..|.|::....||.           :.||            |:.|.....|
Zfish     3 DAAVAKRREQLTRWSGSSTDKEPAVPRSRWRGETSTRAPDGGRPDTNERQKKNRWRVTFEKTAEF 67

  Fly    51 LAACLSGDKDEVVQLLDQ----GAD--INTANVDGLTALHQACIDDNLDMVEFLVERGADINRQD 109
            ||.|.|||.:|...:|.:    |.|  :|.||.||:|||||||||.:::||:||:..||::|:.|
Zfish    68 LAVCASGDTEEAKAMLREVLLNGEDDVVNCANADGITALHQACIDGSMEMVDFLLSHGANVNQVD 132

  Fly   110 NEGWTPLHATASCGFVSIARYLVENGADVAAVNSDGDLALDLAIDVQHMAMIDYMEKMVQELNIN 174
            :|||||||..||||.:.||.:|:::||.:.:||.|||:.||:|.|.....:   ::|.:.:..::
Zfish   133 SEGWTPLHVAASCGNLEIAEFLLQHGASLCSVNCDGDVPLDIAKDEDTQML---LQKHILKQGMD 194

  Fly   175 VDEARKAEELAMLNDAKKWLRSDAAEVDRPHPKTGATALHVAAAKGYTKVLGLLLAGRGNVDRQD 239
            ::.|::|||..:::||:.|| :|....:...|:||||.|||||||||.:.:.||.....:|..:|
Zfish   195 LEAAKRAEEEWIMHDARHWL-TDGLPANLCQPRTGATPLHVAAAKGYLEAIKLLCQCGLDVSAKD 258

  Fly   240 NDGWTPLHAASHWGQRETAEMLVESLADMDIRNYAGQSCIDVADRKIVKFLEELRANKRNKRRPS 304
            .|||||||||:||||.:...:|.|.|.||:..:..|||..||||..:...||||     :||
Zfish   259 CDGWTPLHAAAHWGQSDACRLLAEQLCDMEAHSNRGQSPFDVADESVASLLEEL-----SKR--- 315

  Fly   305 SQIRISDAMENHVEKTPTKLVRVEVRTDATKDAENVKPNQQIHAVEHPVEEEAPWRRKLPRTPSD 369
                                                               :|.||
Zfish   316 ---------------------------------------------------QANWR--------- 320

  Fly   370 SPTNNQVPDRELGTNSSETANDVILRRTQSFENDQKFYQKYNELRARIKANSCPILPANANANAA 434
              |..|         :|:|:|                                 :.|||....::
Zfish   321 --TEQQ---------NSQTSN---------------------------------VNPANKKRRSS 341

  Fly   435 AANKSNNNNNLSSNNYHNNNNNNNKSDLLLGYAAGTTTTTSTPTTTTTTTSSTFNNTHSNTNNTS 499
            ....| :.:.:|..:.......:.:.:|       :....|:|      .|||.::..|...::.
Zfish   342 VCRMS-SKDKISVQDQSKERGVSGELEL-------SDERESSP------ESSTVSSPESTVPSSG 392

  Fly   500 TTQQQPAAAAAASAANQLYSVQRSASLKDNSMYYRKPTVTIATSTAATAINSPSTTVQTPPIRSQ 564
            ||:::
Zfish   393 TTEEK------------------------------------------------------------ 397

  Fly   565 VTAKIAEKSNNGSSSTASVSDAESSKPPPKQSASNMIKNFFKSFVPPVRDEESETQRKAHAKRVR 629
               ::.....:.:|.||.|......:..|.:|.|| .....:.:..||||||||.||||.::.:|
Zfish   398 ---EVKANDQDRASRTAVVPPTPQKRESPAESPSN-TSGDGRKYQAPVRDEESEFQRKARSRLMR 458

  Fly   630 ETRRSTQGVTLDEIKSAEELVKKKNMGMANNNNNNNISTTTTNTISNSGNETSSASSTSAPTPSI 694
            ::|||||||||.::|.||.                                            ||
Zfish   459 QSRRSTQGVTLTDLKEAER--------------------------------------------SI 479

  Fly   695 LGSNEQQD-ELQPPPPPTTPPPAVIPTTTTATDETEIEEVVSSPPAGQSQNDTTASFTLSAPVRR 758
            :..||.|. .:||..|..|..||                          :.||
Zfish   480 VKDNEPQHVSVQPVSPNVTVTPA--------------------------ERDT------------ 506

  Fly   759 SLSTEGEADANSDPEGDQDQTVVSASYTIMPRRERLPESSENVESIRSPQKTEPVAKSSSEDKSE 823
                        |||                 ||.|
Zfish   507 ------------DPE-----------------RESL----------------------------- 513

  Fly   824 EPPHARPTDLPLIPAPAAPSTEAIKSSSAATTPAALESPVRLRDKRGLSGSQESETKSDTASPVS 888
                                                                |::||
Zfish   514 ----------------------------------------------------EAQTK-------- 518

  Fly   889 SHPDFNARDSLLSLYARRTTDSSAGGGGVGGGAGVGAGGASGAATSSSTSAAERRPSWRLKFDAG 953
                                                                             
Zfish   519 ----------------------------------------------------------------- 518

  Fly   954 SKFKLEDITSGGTYPPNNSTIIPSAPAVMAAANLSTTTGVQRRISSGPIALNASNQSLNSVGRPV 1018
                                                 .||:.|
Zfish   519 -------------------------------------LGVRDR---------------------- 524

  Fly  1019 SAPSEGTNNSAYVTPSARKFETNATSTGATTAATTTSNSTSNSVSATSANHTTATAPNATSNHDD 1083
                                                                             
Zfish   525 ----------------------------------------------------------------- 524

  Fly  1084 KDNDKENDNRTQTVIQRRRKPKRRSTGVVHI--DMDELDPERQNESSNNDNEEKEKESGSERTSR 1146
                            |:.:.:|||||||.:  :.|::|   .||.:..||..::.:
Zfish   525 ----------------RKGRKERRSTGVVQLAEENDDMD---ANEDAQQDNNARDHQ-------- 562

  Fly  1147 SRLGSTASTATTSESKSSSSNDKTENGDGIDYKALWEAEKLENDKLRQMLKQKDDEAVQTRATLE 1211
                       ..:|..||          :||:.|:.....||..|::.|::...:..:::..||
Zfish   563 -----------LDDSIHSS----------LDYRKLYLRVLQENGNLKEKLQETQLQLNESKVQLE 606

  Fly  1212 RF----ANATTKNSLSELEKRERRAMERKLSELEEELKQLDAYKSDNHRLKEENAALIRVISKLS 1272
            :.    .|.:.:.:|.|||:.|::.::|:..|||:|||.|...::||.|||:|||||||||||||
Zfish   607 KLKQNQENGSDRPALLELERYEKKLLQRRAFELEDELKVLVDLRADNQRLKDENAALIRVISKLS 671

  Fly  1273 K 1273
            |
Zfish   672 K 672

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mbs	NP_001246786.1	ANKYR	50..300	CDD:440430	115/255 (45%)
		ANK repeat	78..109	CDD:293786	18/30 (60%)
		ANK repeat	111..142	CDD:293786	16/30 (53%)
		ANK repeat	209..239	CDD:293786	15/29 (52%)
		ANK repeat	241..272	CDD:293786	18/30 (60%)
		IPD_PPP1R12	606..648	CDD:412018	24/41 (59%)
		PRKG1_interact	1177..1273	CDD:464927	40/99 (40%)
ppp1r12c	NP_001071047.1	ANKYR	<78..312	CDD:440430	106/237 (45%)
		ANK repeat	101..132	CDD:293786	18/30 (60%)
		ANK repeat	134..165	CDD:293786	16/30 (53%)
		ANK repeat	179..258	CDD:293786	27/82 (33%)
		ANK repeat	260..289	CDD:293786	18/28 (64%)
		IPD_PPP1R12C	428..481	CDD:412020	29/97 (30%)
		PRKG1_interact	572..672	CDD:464927	40/99 (40%)