Protein Alignment Mbs and Ppp1r12c

DIOPT Version :10

• Sequence 1: NP_001246786.1
• Gene: Mbs / 49070
• FlyBaseID: FBgn0005536
• Length: 1273
• Species: Drosophila melanogaster
• Sequence 2: NP_001178875.2
• Gene: Ppp1r12c / 499076
• RGDID: 1584883
• Length: 784
• Species: Rattus norvegicus
• Alignment Length: 1305
• Identity: 310/1305 - (23%)
• Similarity: 444/1305 - (34%)
• Gaps: 580/1305 - (44%)

  Fly    10 SAMMKRAEQLKRWEESDTNRAAPTPRHEHGRRIKFSSGCVFLAACLSGDKDE---VVQLLDQG-- 69
            :|..:|.|||::|  .....|.|.|.....|.::|.....|||||..||.||   :::..|.|
  Rat    19 AARERRQEQLRQW--GARAGADPGPGERRARTVRFERAAEFLAACAGGDLDEARLMLRAADPGPG 81

  Fly    70 --------------ADINTANVDGLTALHQACIDDNLDMVEFLVERGADINRQDNEGWTPLHATA 120
                          |.:::.|.||::||||||||:||::|.||||:||.:|:.|||||||||..|
  Rat    82 SGAATDPAVPPPARAVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAA 146

  Fly   121 SCGFVSIARYLVENGADVAAVNSDGDLALDLAIDVQHMAMIDYMEKMVQELNINVDEARKAEELA 185
            |||::.|||||:.:||::|||||||||.||||   :..||...::..:....::|:.|::|||..
  Rat   147 SCGYLDIARYLLSHGANIAAVNSDGDLPLDLA---ESDAMEGLLKAEITRRGVDVEAAKRAEEEL 208

  Fly   186 MLNDAKKWLRSDAAEVDRPHPKTGATALHVAAAKGYTKVLGLLLAGRGNVDRQDNDGWTPLHAAS 250
            :|:|.:.||...|....| ||:|||:||||||||||.:|:.|||....:.:.:|.|||||||||:
  Rat   209 LLHDTRCWLNGGAMPEAR-HPRTGASALHVAAAKGYIEVMRLLLQAGYDTELRDGDGWTPLHAAA 272

  Fly   251 HWGQRETAEMLVESLADMDIRNYAGQSCIDVADRKIVKFLEELRANKRNKRRPSSQIRISDAMEN 315
            |||..:...:|.|....||...:|||...|:||..::..|||| |.|:
  Rat   273 HWGVEDACRLLAEHGGGMDSLTHAGQRPCDLADEDVMNLLEEL-AQKQ----------------- 319

  Fly   316 HVEKTPTKLVRVEVRTDATKDAENVKPNQQIHAVEHPVEEEAPWRRKLPRTPSDSPTNNQVPDRE 380
                               :|..|.|...|....|                       :|||
  Rat   320 -------------------EDLRNQKEASQGRGQE-----------------------SQVP--- 339

  Fly   381 LGTNSSETANDVILRRTQSFENDQKFYQKYNELRARIKANSCPILPANANANAAA---ANKSNNN 442
              :||....:.|.  |..|.|...  .|..::.|....|...||...:....|.|   |.:....
  Rat   340 --SNSKHRRSSVC--RLSSREKIS--LQDLSKERRPGGAGGLPIGDEDEGEEALAEHPAVEPRAL 398

  Fly   443 NNLSSNNYHNNNNNNNKSDLLLGYAAGTTTTTSTPTTTTTTTSSTFNNTHSNTNNTSTTQQQPAA 507
            |.:||                        ..:|:|.:......:.|:.........|:....|:.
  Rat   399 NGVSS------------------------PASSSPKSPVPPEEAPFSRRFGLQKTGSSGALGPSE 439

  Fly   508 AAAASAANQLYSVQRSAS---LKDNSMYYRKPTVTIATSTAATAINSPSTTVQ---------TPP 560
            ......   :..:|||||   ::..|...|:|.:...|.|.|..:..|.|..:         .||
  Rat   440 RKGTEG---VLGLQRSASSSVIEKASTQAREPRLARITPTPAQKVPEPFTLSEAAAPPSDHSAPP 501

  Fly   561 IRSQVTAKIAEKSNNGSSSTASVSDAESSKPPPKQSASNMIKNFFKSFVPPVRDEESETQRKAHA 625
            .|::..:.:  |.|..::|.|.::|:..             ::..:|:..||||||||:||||.:
  Rat   502 SRTEPGSPV--KPNVLTASAAPLADSRD-------------RDRRRSYQMPVRDEESESQRKARS 551

  Fly   626 KRVRETRRSTQGVTLDEIKSAEELVKKKNMGMANNNNNNNISTTTTNTISNSGNETSSASSTSAP 690
            :.:|::|||||||||.::|.||::..|                                    .|
  Rat   552 RLMRQSRRSTQGVTLTDLKEAEKVAGK------------------------------------VP 580

  Fly   691 TPSILGSNEQQDELQPPPPPTTPPPAVIPTTTTATDETEIEEVVSSPPAGQSQNDTTASFTLSAP 755
            .|.           ||..|...|
  Rat   581 EPE-----------QPALPSLDP------------------------------------------ 592

  Fly   756 VRRSLSTEGEADANSDPEGDQDQTVVSASYTIMPRRERLPESSENVESIRSPQKTEPVAKSSSED 820
                                             .||.|:| ..||.|.
  Rat   593 ---------------------------------SRRPRVP-GVENAEG----------------- 606

  Fly   821 KSEEPPHARPTDLPLIPAPAAPSTEAIKSSSAATTPAALESPVRLRDKRGLSGSQESETKSDTAS 885
                            ||..|.:.|
  Rat   607 ----------------PAQRAEAPE---------------------------------------- 615

  Fly   886 PVSSHPDFNARDSLLSLYARRTTDSSAGGGGVGGGAGVGAGGASGAATSSSTSAAERRPSWRLKF 950
                                            |.|.|..|             |.|.|.:
  Rat   616 --------------------------------GQGQGPQA-------------AREHRKA----- 630

  Fly   951 DAGSKFKLEDITSGGTYPPNNSTIIPSAPAVMAAANLSTTTGVQRRISSGPIALNASNQSLNSVG 1015
                                                     |.:||
  Rat   631 -----------------------------------------GHERR------------------- 635

  Fly  1016 RPVSAPSEGTNNSAYVTPSARKFETNATSTGATTAATTTSNSTSNSVSATSANHTTATAPNATSN 1080
                .|:||..    ..|:.|..|.:....|:|.
  Rat   636 ----GPAEGEE----AVPAERSPECSTVDGGSTV------------------------------- 661

  Fly  1081 HDDKDNDKENDNRTQTVIQRRRKPKRRSTGVVHIDMDELDPERQNESSNNDNEEKEKESGSERTS 1145
                               ||::.:|        |: .|:.::|:|         |.:.|
  Rat   662 -------------------RRQRSQR--------DL-ILESKQQHE---------EPDGG----- 684

  Fly  1146 RSRLGSTASTATTSESKSSSSNDKTENGDGIDYKALWEAEKLENDKLRQMLKQKDDEAVQTRATL 1210
                                            ::.|:...:.||::||:.|.:......|.:..|
  Rat   685 --------------------------------FRKLYTELRRENERLREALTETTLRLAQLKVEL 717

  Fly  1211 -------ERFANATTKNSLSELEKRERRAMERKLSELEEELKQLDAYKSDNHRLKEENAALIRVI 1268
                   ||||.   :.:|.|||:.||||:|||.:|||||||.|...::||.|||:|||||||||
  Rat   718 ERATQRQERFAE---RPALLELERFERRALERKAAELEEELKALSDLRADNQRLKDENAALIRVI 779

  Fly  1269 SKLSK 1273
            |||||
  Rat   780 SKLSK 784

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mbs	NP_001246786.1	ANKYR	50..300	CDD:440430	127/268 (47%)
		ANK repeat	78..109	CDD:293786	20/30 (67%)
		ANK repeat	111..142	CDD:293786	20/30 (67%)
		ANK repeat	209..239	CDD:293786	16/29 (55%)
		ANK repeat	241..272	CDD:293786	16/30 (53%)
		IPD_PPP1R12	606..648	CDD:412018	25/41 (61%)
		PRKG1_interact	1177..1273	CDD:464927	48/102 (47%)
Ppp1r12c	NP_001178875.2	ANKYR	<94..326	CDD:440430	118/272 (43%)
		ANK repeat	104..135	CDD:293786	20/30 (67%)
		ANK repeat	137..168	CDD:293786	20/30 (67%)
		ANK repeat	230..261	CDD:293786	17/30 (57%)
		ANK repeat	263..287	CDD:293786	14/23 (61%)
		PRK12323	<477..780	CDD:481241	126/739 (17%)
		IPD_PPP1R12	534..578	CDD:424067	25/43 (58%)
		PRKG1_interact	685..784	CDD:464927	48/101 (48%)