DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mbs and mel-11

DIOPT Version :10

Sequence 1:NP_001246786.1 Gene:Mbs / 49070 FlyBaseID:FBgn0005536 Length:1273 Species:Drosophila melanogaster
Sequence 2:NP_001021928.1 Gene:mel-11 / 174484 WormBaseID:WBGene00003196 Length:1124 Species:Caenorhabditis elegans


Alignment Length:1391 Identity:342/1391 - (24%)
Similarity:555/1391 - (39%) Gaps:424/1391 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 KRAEQLKRWEESDTNRAAPTPRHEHGRRIKFSSGCVFLAACLSGDKDEVVQLLDQGADINTANVD 78
            ||.:||:||:.|:.|  |...|.....:::|....:||:||:|||::||.:||::||:|||..||
 Worm    25 KRKDQLRRWQSSEMN--AEAARRTKRPKVQFQDSDIFLSACMSGDEEEVEELLNKGANINTCTVD 87

  Fly    79 GLTALHQACIDDNLDMVEFLVERGADINRQDNEGWTPLHATASCGFVSIARYLVENGADVAAVNS 143
            |||||||:.||...:||.||.|:|||:|.|||||||||||.|.||.|:|.|||.::|||::.|||
 Worm    88 GLTALHQSVIDSKPEMVRFLCEKGADVNAQDNEGWTPLHAAACCGNVAIVRYLCQHGADLSIVNS 152

  Fly   144 DGDLALDLAIDVQHMAMIDYMEKMVQELNINVDEARKAEELAMLNDAKKWLRSDAAEVDRPHPKT 208
            |.:||||||:|.|   ..||::...:...|::|..|..|...||.|...|: |.....|.||.:|
 Worm   153 DKELALDLAVDEQ---CRDYLDDDYKRQMIDLDACRDQELQTMLKDVNMWM-SQGEYRDIPHHRT 213

  Fly   209 GATALHVAAAKGYTKVLGLLLAGRGNVDRQDNDGWTPLHAASHWGQRETAEMLVESLADMDIRNY 273
            |.||:||||.:|||::|.||:...|||..||.:||||||||:||.:|:..::|:|:.|::....:
 Worm   214 GGTAMHVAAGRGYTQLLELLIKAGGNVRAQDVEGWTPLHAAAHWAERDACKILLENGAELSDLTF 278

  Fly   274 AGQSCIDVADRKIVKFLEELRANKRNKRRPSSQIRISDAMENHVEKTPTKLVRVEVRTDATKDAE 338
            .|...:.|||::.:.:|.||                                           |:
 Worm   279 TGADVLGVADKECIDYLVEL-------------------------------------------AD 300

  Fly   339 NVKPNQQIHAVEHPVEEEAPWRRKLPRTPSDSPT------NNQVPDRELGTNSSETANDVILRRT 397
            .||...               :||.|.:.|..||      |:::|..|....:||...| :..:.
 Worm   301 TVKVQN---------------KRKSPGSGSQPPTSILQEKNHRMPSHEEHVLTSERKRD-LQHKD 349

  Fly   398 QSFENDQKFYQKYNELRARIKANSCPILPANANANAAAANKSNNNNNLSSNNYHNNNNNNNKSDL 462
            |..||:  |...:               |:.|                                 
 Worm   350 QHSENE--FLHSH---------------PSTA--------------------------------- 364

  Fly   463 LLGYAAGTTTTTSTPTTTTTTTSSTFNNTHSNTNNTSTTQQQPAAAAAASAANQLYSVQRSASLK 527
                :.|:||:::|.|||||..        ...|:.|..|:....::..||.             
 Worm   365 ----SVGSTTSSNTNTTTTTIV--------IGENDISAAQKDSRESSKESAV------------- 404

  Fly   528 DNSMYYRKPTVTIATSTAATAINSPSTTVQTPPIRSQVTAKIAEKSNNGSSSTASVSDAESSKPP 592
            |:..|                                    :||.....:.......|.|..:  
 Worm   405 DDEEY------------------------------------VAEDEMEEAEEDEEEEDVEEEE-- 431

  Fly   593 PKQSASNMIKNFFKSFVPPVRDEESETQRKAHAKRVRETRRSTQGVTLDEIKSAEELVKKKNMGM 657
             ::.:...:||  ...:.|:|.|.:       :.|.....||..|.| |...|..|...:.:.. 
 Worm   432 -EEKSEAELKN--GKEISPLRSETT-------SSRSISITRSLDGYT-DRSSSGRETSAEMSEA- 484

  Fly   658 ANNNNNNNISTTTTNTISNSGNETSSASSTSAPTP-------SILGSNEQQDELQPPPPPTTPPP 715
            |::.:....|:::..|.|...::.|:|.|....||       |.:||.:|......|..|.:.||
 Worm   485 ASSASTGTTSSSSRFTSSTPSSQRSAAGSVHTETPRSSMENSSSVGSGDQNVSATIPIVPLSAPP 549

  Fly   716 AVI-------------------PTTTTATDETEIEEVVSSPPAGQSQ-------NDTTASFTL-- 752
            ..:                   .::.|.:..|.:.|::|.|.:..||       |.||.:.|:  
 Worm   550 KAVHQSPSSWINRGVPLSSRSSTSSVTRSSSTPVSEIISPPSSIHSQLSFPSVSNTTTTTATVAP 614

  Fly   753 ------SAPVRRSLSTEGEADANSDPEGDQDQTVVSASYTIMPRRERLPESSENVESIRSPQKTE 811
                  |.||...::....:.|.:.|......|.::|::                        ::
 Worm   615 TSSTVPSTPVSNVMAATISSTAKNTPSPAGSVTTINATF------------------------SK 655

  Fly   812 PVAKSSSEDKSEEPPHARPTDLP---LIPAPAAPSTEAIKS----------SSAATTP--AALES 861
            |.::..||:....|  ::||::|   |.......||..|:|          ||.::.|  :|..|
 Worm   656 PSSRHPSEEVYRSP--SQPTNVPWASLWHNVNNASTGQIRSHIEQLRNASFSSLSSYPRVSAFRS 718

  Fly   862 PVRLRDKRGLSGSQESETKSDTASPVSSHPDFNARDSLLSLYARRTTDSSAGGGGVGGGAGVGAG 926
            |::.        :..|.:.:..:||:...|  :....:::.|.|...........:         
 Worm   719 PIKT--------TASSTSVNSASSPLLLQP--HPHPPVIAEYPRGFVPQQINPNKM--------- 764

  Fly   927 GASGAATSSSTSAAERRPSWRL--------------KFDAGSKFKLEDITSGGTYPPNNSTIIPS 977
             :...:.:.:.|.||||.:.|:              :.:..|||..:::..      .||.::.:
 Worm   765 -SRWQSKTVTESEAERRNNSRMQRQHRRSTQGVTKEQLEEASKFATDEVAR------RNSQVLST 822

  Fly   978 APAVMAA------ANLSTTTGVQRRISSGPIALNASNQSLNSVGRPVSAPSEGTNNSAYVTPSAR 1036
            .|..:.|      .:||:|:.   .:..|.::..|:...:||       |:   :|||.|...::
 Worm   823 YPNSLHARLASEEKDLSSTSD---DLKDGDVSTTATVSLINS-------PN---SNSANVRRKSQ 874

  Fly  1037 KFETNATSTGAT--------TAATTTSNSTSNSVSATSANHTTATAPNATSNHDDKDNDKENDNR 1093
            ....:.::..||        ..|.:...:|:...|..|......|.|..||...:|         
 Worm   875 GLSISRSNRRATGPVNPEDLAPAMSLRLATAQPYSPASVRSNAGTLPTMTSRFSEK--------- 930

  Fly  1094 TQTVIQRRRKPKRRSTGVVHIDMDELDPERQNESSNNDNEEKE------KESGSERTSRSRLGST 1152
                                  ...|.|.....||......:.      ..:.|.||: :.|.||
 Worm   931 ----------------------AQSLPPASNGMSSTQPLSTRSAIVAGLSSAPSMRTT-APLSST 972

  Fly  1153 ASTATTSESKSSSSNDKTENGD--------------GIDYKALWEAEKLENDKLRQMLKQKDDEA 1203
            |:::....|.|.|||..:.|..              .::||||:|.|:.|.::||     ::.|.
 Worm   973 ATSSRFMPSSSLSSNGSSANQQPSSIYGLQSRPTETNLNYKALFEKERSECERLR-----REMEE 1032

  Fly  1204 VQTRATLERFANATTK----------------------NSLSELEKRERRAMERKLSELEEELKQ 1246
            ::...|.:.:..|:|:                      .||:..::.|||:||||:|:||.:||.
 Worm  1033 MRRSQTADSYRGASTQLAWRARNASPSAQPHNLSVAKSTSLASFDENERRSMERKISDLELQLKT 1097

  Fly  1247 LDAYKSDNHRLKEENAALIRVISKLS 1272
            ....:.:|.||||||.||:|||||::
 Worm  1098 ATNLRMENQRLKEENGALVRVISKMT 1123

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MbsNP_001246786.1 ANKYR 50..300 CDD:440430 124/249 (50%)
ANK repeat 78..109 CDD:293786 19/30 (63%)
ANK repeat 111..142 CDD:293786 19/30 (63%)
ANK repeat 209..239 CDD:293786 16/29 (55%)
ANK repeat 241..272 CDD:293786 14/30 (47%)
IPD_PPP1R12 606..648 CDD:412018 10/41 (24%)
PRKG1_interact 1177..1273 CDD:464927 41/118 (35%)
mel-11NP_001021928.1 ANKYR <54..307 CDD:440430 127/314 (40%)
ANK repeat 87..118 CDD:293786 19/30 (63%)
ANK repeat 120..151 CDD:293786 19/30 (63%)
ANK repeat 153..244 CDD:293786 40/94 (43%)
ANK repeat 246..271 CDD:293786 13/24 (54%)
ANK repeat 279..306 CDD:293786 10/69 (14%)
IPD_PPP1R12 760..806 CDD:412018 6/55 (11%)
PRKG1_interact 1011..1124 CDD:464927 41/118 (35%)

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