Protein Alignment Src64B and BLK

DIOPT Version :10

• Sequence 1: NP_001286937.1
• Gene: Src64B / 48973
• FlyBaseID: FBgn0262733
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: XP_011542126.1
• Gene: BLK / 640
• HGNCID: 1057
• Length: 531
• Species: Homo sapiens
• Alignment Length: 552
• Identity: 249/552 - (45%)
• Similarity: 336/552 - (60%)
• Gaps: 64/552 - (11%)

  Fly    43 MGGVLGQKHNNGGSLDSRYTPDPNHRGPLKIGGKGGVDIIRPRTTPTGVPGVVL----------- 96
            ||.|..:|.:....:..:   |.....|||:..       :.:..|...|.||.
Human     1 MGLVSSKKPDKEKPIKEK---DKGQWSPLKVSA-------QDKDAPPLPPLVVFNHLTPPPPDEH 55

  Fly    97 ----KRVVVALYDYKSRDESDLSFMKGDRMEVIDDTESDWWRVVNLTTRQEGLIPLNFVAEERSV 157
                |..|||||||.:.::.||..:||::::|:..| .|||...:|.|.:||.:|.||||...|:
Human    56 LDEDKHFVVALYDYTAMNDRDLQMLKGEKLQVLKGT-GDWWLARSLVTGREGYVPSNFVARVESL 119

  Fly   158 NSEDWFFENVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWEDGRGYHVKHYRIKPLD 222
            ..|.|||.:..||||::.|||..|..|:||:|.||.|...:|||||| ...:|..:|||:|:.||
Human   120 EMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKD-VTTQGELIKHYKIRCLD 183

  Fly   223 NGGYYIATNQTFPSLQALVMAYSKENALGLCHILSRPCPKPQPQMWDLGPELRDKYEIPRSEIQL 287
            .|||||:...|||||||||..|||:.. |||..|:.||.:|.||    .|..:|::||||..::|
Human   184 EGGYYISPRITFPSLQALVQHYSKKGD-GLCQRLTLPCVRPAPQ----NPWAQDEWEIPRQSLRL 243

  Fly   288 LRKLGRGNFGEVFYGKWRNSIDVAVKTLREGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQEEP 352
            :||||.|.||||:.|.::|::.||:|||:|||||..|||.||.:||..:|.|||.||||.: :||
Human   244 VRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLYAVVT-KEP 307

  Fly   353 IYIVQEYMSKGS--------------------------LLDFLREGDGRYLHFEDLIYIATQVAS 391
            ||||.|||::|.                          |||||:..:|..|....||.::.|:|.
Human   308 IYIVTEYMARGGAPRRAASSERGGRAGLSRRRRVRCGCLLDFLKTDEGSRLSLPRLIDMSAQIAE 372

  Fly   392 GMEYLESKQLIHRDLAARNVLIGENNVAKICDFGLARVIADDEYCPKQGSRFPVKWTAPEAIIYG 456
            ||.|:|....|||||.|.|:|:.|....||.||||||:| |.||..::|::||:||||||||.:|
Human   373 GMAYIERMNSIHRDLRAANILVSEALCCKIADFGLARII-DSEYTAQEGAKFPIKWTAPEAIHFG 436

  Fly   457 KFSIKSDVWSYGILLMELFTYGQVPYPGMHSREVIENIERGFRMPKPTNHYFPDNIYQ-LLLQCW 520
            .|:||:||||:|:||||:.|||:||||||.:.|||.|:|||:|||:|..  .|..:|: ::.:||
Human   437 VFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDT--CPPELYRGVIAECW 499

  Fly   521 DAVPEKRPTFEFLNHYFESFSVTSEVPYREVQ 552
            .:.||:|||||||....|.|...:|..| |:|
Human   500 RSRPEERPTFEFLQSVLEDFYTATERQY-ELQ 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH2_Src_family	158..259	CDD:199827	53/100 (53%)
		PTKc_Src_like	289..538	CDD:270630	139/275 (51%)
		SH3_Src_like	99..150	CDD:212779	21/50 (42%)
BLK	XP_011542126.1	SH3_Blk	62..115	CDD:212942	24/53 (45%)
		SH2_Src_Blk	120..219	CDD:198234	53/100 (53%)
		Protein Kinases, catalytic domain	233..522	CDD:473864	146/292 (50%)