Protein Alignment Src64B and map3k21

DIOPT Version :10

• Sequence 1: NP_001286937.1
• Gene: Src64B / 48973
• FlyBaseID: FBgn0262733
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: XP_005156983.1
• Gene: map3k21 / 561518
• ZFINID: ZDB-GENE-090312-24
• Length: 1017
• Species: Danio rerio
• Alignment Length: 488
• Identity: 124/488 - (25%)
• Similarity: 185/488 - (37%)
• Gaps: 141/488 - (28%)

  Fly    65 PNHRGPLKIGGKGGVDIIRPRTTPTGVPGVVLKRVVVALYDYKSRDESDLSFMKGDRMEVID--- 126
            ||..|.|.:......:....|......| |..:.:..|::||::..|.:||..:||.:||:.
Zfish     9 PNGEGRLSLQDHVCTESSNSRAWAHSAP-VCPRSLWTAVFDYEASGEDELSLRRGDVVEVLSKDA 72

  Fly   127 --DTESDWWRVVNLTTRQEGLIPLNFVAEERSVNSEDWFFENVLRKEADKLLLAEENPRGTFLVR 189
              ..:..||  ......:.|:.|.|:|.           |:.|:
Zfish    73 AISGDEGWW--TGKINHRVGIFPSNYVT-----------FQPVI--------------------- 103

  Fly   190 PSEHNPNGYSLSVKDWEDGRGYHVKHYRIKPLDNGGYYIATNQTFPSLQALVMAYSKENALGLCH 254
                                      ||.         :...::.||...
Zfish   104 --------------------------YRA---------VGARESDPSAPV--------------- 118

  Fly   255 ILSRPCPKPQPQMWDLGPELRDKYEIPRSEIQLLRKLGRGNFGEVFYGKWRNSIDVAVKTLR--- 316
                                    .||.||:.|...:|.|.||:|:.|.|:.. :||||..|
Zfish   119 ------------------------RIPFSELVLQEIIGVGGFGKVYRGTWKVQ-EVAVKAARQDP 158

  Fly   317 -EGTMSTA-AFLQEAAIMKKFRHNRLVALYAVCSQEEPIYIVQEYMSKGSLLDFLREGDGRYLHF 379
             |...:|| :..|||.:....:|..::.|..||.:|..:.:|.||...|:|   .|...||.:..
Zfish   159 DEDIKATADSVKQEAKLFSMLQHPNIIKLEGVCLEEPNLCLVMEYARGGTL---NRALTGRRIPP 220

  Fly   380 EDLIYIATQVASGMEYLESK---QLIHRDLAARNVLIGE--------NNVAKICDFGLARVIADD 433
            ..|:..|.|:|.||:||..:   .:|||||.:.|:|:.|        ....||.||||||   :.
Zfish   221 HILVNWAVQIARGMQYLHEEAVVPIIHRDLKSSNILLLEKIENDDIGRKTLKITDFGLAR---EW 282

  Fly   434 EYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREVIENIE-RG 497
            ....|..:.....|.|||.|....||..|||||||:||.||.| |::||.|:....|...:. ..
Zfish   283 HKTTKMSAAGTYSWMAPEVIKSSLFSKGSDVWSYGVLLWELLT-GEIPYRGIDGLAVAYGVAVNK 346

  Fly   498 FRMPKPTNHYFPDNIYQLLLQCWDAVPEKRPTF 530
            ..:|.|:.  .|:...:|:.:||:..|..||:|
Zfish   347 LTLPIPST--CPEPFAKLMEECWEQDPHIRPSF 377

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH2_Src_family	158..259	CDD:199827	6/100 (6%)
		PTKc_Src_like	289..538	CDD:270630	90/259 (35%)
		SH3_Src_like	99..150	CDD:212779	14/55 (25%)
map3k21	XP_005156983.1	SH3_MLK1-3	42..99	CDD:212992	16/69 (23%)
		STKc_MLK4	130..387	CDD:271048	90/258 (35%)