Protein Alignment Src64B and LYN

DIOPT Version :10

• Sequence 1: NP_001286937.1
• Gene: Src64B / 48973
• FlyBaseID: FBgn0262733
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_002341.1
• Gene: LYN / 4067
• HGNCID: 6735
• Length: 512
• Species: Homo sapiens
• Alignment Length: 453
• Identity: 219/453 - (48%)
• Similarity: 314/453 - (69%)
• Gaps: 10/453 - (2%)

  Fly    99 VVVALYDYKSRDESDLSFMKGDRMEVIDDTESDWWRVVNLTTRQEGLIPLNFVAEERSVNSEDWF 163
            :|||||.|......||||.||::|:|::: ..:||:..:|.|::||.||.|:||:..::.:|:||
Human    67 IVVALYPYDGIHPDDLSFKKGEKMKVLEE-HGEWWKAKSLLTKKEGFIPSNYVAKLNTLETEEWF 130

  Fly   164 FENVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWEDGRGYHVKHYRIKPLDNGGYYI 228
            |:::.||:|::.|||..|..|.||:|.||.....:||||:|::...|..:|||:|:.||||||||
Human   131 FKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDNGGYYI 195

  Fly   229 ATNQTFPSLQALVMAYSKENALGLCHILSRPCPKPQPQM-WDLGPELRDKYEIPRSEIQLLRKLG 292
            :...|||.:..::..|.|: |.|||..|.:.|..|:||. ||     :|.:||||..|:|:::||
Human   196 SPRITFPCISDMIKHYQKQ-ADGLCRRLEKACISPKPQKPWD-----KDAWEIPRESIKLVKRLG 254

  Fly   293 RGNFGEVFYGKWRNSIDVAVKTLREGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQEEPIYIVQ 357
            .|.||||:.|.:.||..||||||:.||||..|||:||.:||..:|::||.||||.::||||||:.
Human   255 AGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIIT 319

  Fly   358 EYMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKIC 422
            |||:||||||||:..:|..:....||..:.|:|.||.|:|.|..|||||.|.|||:.|:.:.||.
Human   320 EYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIA 384

  Fly   423 DFGLARVIADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHS 487
            ||||||||.|:||..::|::||:||||||||.:|.|:|||||||:||||.|:.|||::||||..:
Human   385 DFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTN 449

  Fly   488 REVIENIERGFRMPKPTNHYFPDNIYQLLLQCWDAVPEKRPTFEFLNHYFESFSVTSEVPYRE 550
            .:|:..:.:|:|||:..|  .||.:|.::..||....|:||||::|....:.|...:|..|::
Human   450 ADVMTALSQGYRMPRVEN--CPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFYTATEGQYQQ 510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH2_Src_family	158..259	CDD:199827	45/100 (45%)
		PTKc_Src_like	289..538	CDD:270630	133/248 (54%)
		SH3_Src_like	99..150	CDD:212779	22/50 (44%)
LYN	NP_002341.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..62
		SH3_Lyn	67..122	CDD:212937	25/55 (45%)
		SH2_Src_Lyn	125..225	CDD:198227	45/100 (45%)
		PTKc_Lyn	239..510	CDD:270657	142/272 (52%)