Protein Alignment Src64B and syk

DIOPT Version :10

• Sequence 1: NP_001286937.1
• Gene: Src64B / 48973
• FlyBaseID: FBgn0262733
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: XP_005155595.1
• Gene: syk / 405769
• ZFINID: ZDB-GENE-040702-3
• Length: 608
• Species: Danio rerio
• Alignment Length: 638
• Identity: 174/638 - (27%)
• Similarity: 267/638 - (41%)
• Gaps: 164/638 - (25%)

  Fly    28 YTFG-------QTHINSSGGGNMGGVLGQKHN--NGGSLDSRY-------------------TPD 64
            |.||       :.::...|.|:...:|.|..:  .|.:|...|                   ...
Zfish    10 YFFGNITREESEVYLQQGGSGDGLYLLRQSRSFLGGYALSLSYGRQFYHYTIERELNDTYAIAGG 74

  Fly    65 PNHRGPLKIGGKGGVDII-------------------RPR-TTPTGVPGVVLKRVVVALYDYKSR 109
            .:||.|        :|:|                   ||| |.|...|...||..::..|..::.
Zfish    75 KSHRTP--------IDVINYHSQESDGLICLLKKPFHRPRGTEPKVGPFEDLKEQLIRQYVEQTW 131

  Fly   110 DESDLSFMKGDRMEVIDDTESDWWRVVNLTTRQEGLIPLNFVAEERSVNSEDWFFENVLRKEADK 174
            :      :||..::         ..:::...:.|.||..  .|.|:.    .||...:.|::::.
Zfish   132 N------LKGSALD---------QAIISQRPQLEKLIAT--TAHEKM----PWFHGKIDREDSEL 175

  Fly   175 LLLAEENPRGTFLVRPSEHN--PNGYSLSVKDWEDGRGYHVKHYRIKPLDNGGYYIATNQTFPSL 237
            .||......|.||:|..|::  ...|:|.:.     ....|.||||.....|...|...:.|.:|
Zfish   176 RLLNTSRVNGKFLIRQRENSGRNESYALCLL-----HNNQVMHYRIDKDRAGKLSIPDGKKFDTL 235

  Fly   238 QALVMAYSKENALGLCHILSRPCPKPQ------------------------------PQMWDLGP 272
            ..||..||.:.. ||..:|:..||:|.                              ...:.:.|
Zfish   236 WQLVEHYSYKPD-GLLRVLTETCPRPSHHSERGATGGIISRLKSYSFPKPGQKKGSAENPYKITP 299

  Fly   273 ELRDK------------------YEIPRSEIQLLR--------------KLGRGNFGEVFYGKW- 304
            ..:|.                  ||.|.::...||              :||.||||.|..|.:
Zfish   300 NGKDDYSKQGNFLDSAMPMDTQVYESPYADPDELRSTKVNRSDLTLEDGELGSGNFGTVLRGVYQ 364

  Fly   305 --RNSIDVAVKTLREGTMSTAA---FLQEAAIMKKFRHNRLVALYAVCSQEEPIYIVQEYMSKGS 364
              :....||||.|:....:.|.   .|:||.:|::..:..:|.:..:| :.|.:.:|.|....|.
Zfish   365 MKKTQKVVAVKILKNDDDNAAVKDEMLREANVMQQLDNPYIVRMIGIC-EAENLMLVMELAELGP 428

  Fly   365 LLDFLREGDGRYLHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKICDFGLARV 429
            |..||::  .:::..::|..:..||:.||:|||....:||||||||||:...:.|||.||||::.
Zfish   429 LHKFLQK--NKHITVKNLTELVHQVSMGMKYLEEHNFVHRDLAARNVLLVTQHYAKISDFGLSKA 491

  Fly   430 IADDE--YCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREVIE 492
            :.:||  |..|...::|:||.|||.:.|.|||.||||||:|:|:.|.|:|||.||.||...|||:
Zfish   492 LTEDENYYKAKGHGKWPLKWYAPECMNYLKFSSKSDVWSFGVLMWEAFSYGQKPYKGMKGNEVIQ 556

  Fly   493 NIERGFRMPKPTNHYFPDNIYQLLLQCWDAVPEKRPTFEF----LNHYFESFS 541
            .||.|.||..|.:  .|..:|.|:.:||...|::||.|..    |.||:...|
Zfish   557 MIENGQRMSAPPD--CPPEMYDLMKKCWTYKPDERPGFSVVEPRLRHYYYDIS 607

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH2_Src_family	158..259	CDD:199827	28/102 (27%)
		PTKc_Src_like	289..538	CDD:270630	105/274 (38%)
		SH3_Src_like	99..150	CDD:212779	6/50 (12%)
syk	XP_005155595.1	SH2_N-SH2_Zap70_Syk_like	8..111	CDD:198191	19/108 (18%)
		SH2_C-SH2_Syk_like	159..260	CDD:198264	31/110 (28%)
		PTKc_Syk	348..604	CDD:133247	104/260 (40%)