Protein Alignment Src64B and Bmx

DIOPT Version :10

• Sequence 1: NP_001286937.1
• Gene: Src64B / 48973
• FlyBaseID: FBgn0262733
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_001102486.1
• Gene: Bmx / 367786
• RGDID: 1565643
• Length: 655
• Species: Rattus norvegicus
• Alignment Length: 534
• Identity: 183/534 - (34%)
• Similarity: 267/534 - (50%)
• Gaps: 86/534 - (16%)

  Fly    64 DPNHRGP------LKIGGKGGVDIIRPRTTPTGVPGVVLK------RVVVALYD------YKSRD 110
            |..||.|      |||          ||..|      :||      ..:...||      |.|:.
  Rat   162 DEKHRAPTFPERILKI----------PRAVP------ILKMDASSSSAIPPQYDSHLKKSYDSQP 210

  Fly   111 ESDLSFMKGDRMEVIDDTESDWWRVVNLTTRQE----GLIPLNFVA-----------------EE 154
            ..::.::..:..       .|||::....:.::    ..:..|.|:                 ||
  Rat   211 TVNIRYIPREDC-------PDWWQIRKPKSEEDIARSNQLERNIVSHSPSKMSWGFPESSSSEEE 268

  Fly   155 RSVNSEDWFFENVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSV--KDWEDGRGYHVKHYR 217
            .::::.|||..|:.|.:::: ||.::...|.|:||.|. ....|::|:  |...|.:| .||||.
  Rat   269 ENLDAYDWFAGNISRSQSEQ-LLRQKGKEGAFMVRNSS-QMGMYTVSLFSKAVNDKKG-TVKHYH 330

  Fly   218 IKPLDNGGYYIATNQTFPSLQALVMAYSKENALGLCHILSRPC---PKPQPQMWDLGPELRDKYE 279
            :........|:|.|..|.|:..|: .|.:.|:.|:...|..|.   ....|....||..:   :|
  Rat   331 VHTNAENKLYLAENYCFDSIPKLI-HYHQHNSAGMITRLRHPVSTKANKVPVSVALGSGI---WE 391

  Fly   280 IPRSEIQLLRKLGRGNFGEVFYGKWRNSIDVAVKTLREGTMSTAAFLQEAAIMKKFRHNRLVALY 344
            :.|.||.||::||.|.||.|..|||:....||||.::||.||...|.|||..|.|..|.:||..|
  Rat   392 LKREEIALLKELGSGQFGVVQLGKWKGQYSVAVKMIKEGAMSEDEFFQEAQTMMKLSHPKLVKFY 456

  Fly   345 AVCSQEEPIYIVQEYMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLESKQLIHRDLAAR 409
            .|||::.|||||.||::.|.||::|: ..|:.|....|:.:...|..||.:|||.|.||||||||
  Rat   457 GVCSKKYPIYIVTEYITNGCLLNYLK-NHGKGLESSQLLEMCYDVCEGMAFLESHQFIHRDLAAR 520

  Fly   410 NVLIGENNVAKICDFGLARVIADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMEL 474
            |.|:..:...|:.|||:.|.:.||:|....|::|||||:|||...|.|:|.|||||::|||:.|:
  Rat   521 NCLVDSDLSVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEV 585

  Fly   475 FTYGQVPYPGMHSREVIENIERGFRMPKPTNHYFPDNIYQLLLQCWDAVPEKRPTFEFLNHYFES 539
            |:.|:.||....:.||:..:.:|.|:.:|  ....|.|||::..||..:|||||||:.|....|
  Rat   586 FSLGKQPYDLYDNSEVVVKVSQGHRLYRP--QLASDTIYQIMYSCWHELPEKRPTFQQLLSAIE- 647

  Fly   540 FSVTSEVPYREVQD 553
                   |.|| ||
  Rat   648 -------PLRE-QD 653

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH2_Src_family	158..259	CDD:199827	31/102 (30%)
		PTKc_Src_like	289..538	CDD:270630	113/248 (46%)
		SH3_Src_like	99..150	CDD:212779	7/60 (12%)
Bmx	NP_001102486.1	PH_Btk	25..151	CDD:269944
		SH2_Tec_Bmx	269..374	CDD:198262	32/108 (30%)
		Protein Kinases, catalytic domain	392..647	CDD:473864	118/257 (46%)