DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Src64B and jak2b

DIOPT Version :10

Sequence 1:NP_001286937.1 Gene:Src64B / 48973 FlyBaseID:FBgn0262733 Length:553 Species:Drosophila melanogaster
Sequence 2:NP_571162.1 Gene:jak2b / 30298 ZFINID:ZDB-GENE-980526-123 Length:1126 Species:Danio rerio


Alignment Length:648 Identity:165/648 - (25%)
Similarity:258/648 - (39%) Gaps:189/648 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 KRQDQELALAYPTG-------GYKKSDYTFGQTHINSSGGGNMGGVLGQKHNN-------GGSLD 58
            |::|.||..:...|       |.:|....:|:||....    :..||.:.|.|       ..|:.
Zfish   524 KKEDLELGESQGQGTFTKIFKGIRKEQGDYGETHKTEV----IVKVLDKAHRNYSESFFEAASMM 584

  Fly    59 SRYTPDPNHRGPLKIGGKGGVDIIRPRTTPTGVPGVVLKRVVV--ALYDYKSRDESDLSFMKGDR 121
            |:.|    |:..:...|          ....|...::::..|.  :|..|..:::|.:|.....:
Zfish   585 SQLT----HKHLVLTYG----------ICVCGDENIMVQEYVKFGSLDTYLKKNKSSVSVNILWK 635

  Fly   122 MEVIDDTESDWWRVVNLTTRQEGLIPLNFVAEERSVNSEDWFFENVLR-KEADKLL-----LAEE 180
            :||.....   |.::.|              ||:|:...:...:|:|. :|.|:.|     :...
Zfish   636 LEVAKQLA---WAMLYL--------------EEKSLAHGNVCAKNILLIREEDRALGNTPFIKLS 683

  Fly   181 NPRGTFLVRPSE--------------HNPNGYSLSVKDWEDGRGYHVKHYRIKPLDNGGYYIATN 231
            :|..:..|.|.|              .:|...||:...|..|.       .:..:.:||.....|
Zfish   684 DPGISITVLPREILVERIPWVPPECILDPKNLSLATDKWSFGT-------TLWEICSGGEQPLAN 741

  Fly   232 QTFPSLQALVMAYSKENALGLCHILSRPCPKPQPQMW-----------DLGPELRDK-------- 277
                      |..||::.....| ...|.||     |           |..|..|..        
Zfish   742 ----------MDNSKKHLFYENH-HQLPAPK-----WTELANLINSCMDYEPTFRPSFKAIIRDL 790

  Fly   278 -------YEIPR-SEIQ----------------------------LLRKLGRGNFGEVFYGKWRN 306
                   |||.: |:|.                            .|::||:||||.|...::..
Zfish   791 NSLFCPDYEIVKESDIMPSRAAASIFNTGTFKNNEPVQFEERHLIFLQQLGKGNFGSVEMCRYDP 855

  Fly   307 SID-----VAVKTLREGTMS-TAAFLQEAAIMKKFRHNRLVALYAVC--SQEEPIYIVQEYMSKG 363
            ..|     ||||.|:..|.. ...|.:|..|:|..:|..:|....||  :....:.:|.||:..|
Zfish   856 LQDNTGEVVAVKKLQHSTTEHIRDFEREIEILKSLQHENIVKYKGVCYGAGRRNLRLVMEYLPYG 920

  Fly   364 SLLDFLREGDGRYLHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKICDFGLAR 428
            ||.|:|.:...|..| :.|::.|:|:..|||||.:|:.||||||.||:|:......||.||||.:
Zfish   921 SLRDYLNKNRDRIDH-QKLVHYASQICKGMEYLATKRYIHRDLATRNILVESECRVKIGDFGLTK 984

  Fly   429 VIADDE--YCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTY-------------- 477
            |:..|:  |..|:....|:.|.|||::...|||:.|||||:|::|.|||||              
Zfish   985 VLPQDKEYYKVKEPGESPIFWHAPESLTESKFSVASDVWSFGVVLYELFTYSDKLCSPPTVFLSM 1049

  Fly   478 ------GQ-VPYPGMHSREVIENIERGFRMPKPTNHYFPDNIYQLLLQCWDAVPEKRPTFEFL 533
                  || :.|      .:||.::||.|:|:|..  .|..:::::.:|||..|..||.|:.|
Zfish  1050 VGGDKQGQTIVY------HLIELLKRGNRLPQPMG--CPTEMFEIMQECWDNDPSLRPNFKEL 1104

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Src64BNP_001286937.1 SH2_Src_family 158..259 CDD:199827 21/120 (18%)
PTKc_Src_like 289..538 CDD:270630 99/276 (36%)
SH3_Src_like 99..150 CDD:212779 9/52 (17%)
jak2bNP_571162.1 FERM_F1 30..126 CDD:465733
FERM_F2 134..253 CDD:436450
FERM_C_JAK2 258..370 CDD:270141
SH2_Jak2 370..466 CDD:198242
Protein Kinases, catalytic domain 528..791 CDD:473864 58/320 (18%)
Protein Kinases, catalytic domain 829..1112 CDD:473864 100/285 (35%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.