Protein Alignment Src64B and FGFR2

DIOPT Version :10

• Sequence 1: NP_001286937.1
• Gene: Src64B / 48973
• FlyBaseID: FBgn0262733
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_075259.4
• Gene: FGFR2 / 2263
• HGNCID: 3689
• Length: 822
• Species: Homo sapiens
• Alignment Length: 611
• Identity: 172/611 - (28%)
• Similarity: 257/611 - (42%)
• Gaps: 135/611 - (22%)

  Fly     9 RQDQELALAYPTGGYK--KSDYTFGQTHINSSGGGNMGGVLGQKHNNGGSLDSRYTPDPNHRGPL 71
            :..:|....:..||||  ...::.....:..|..||...|:   .|..||::..|..|...|.|.
Human   193 KNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVV---ENEYGSINHTYHLDVVERSPH 254

  Fly    72 KIGGKGGVDIIRPRTTPTGVPGVVLKRVVVALYDYKSRDESDLSFMKGDRMEVIDDTES--DWWR 134
            :...:.|:    |....|.|.|                   |:.|:    .:|..|.:.  .|.:
Human   255 RPILQAGL----PANASTVVGG-------------------DVEFV----CKVYSDAQPHIQWIK 292

  Fly   135 VVNLTTRQEGL--IPLNFVAEERSVNS---EDWFFENVLRKEADKLL------LAEENPRGTFLV 188
            .|.....:.|.  :|...|.:...:||   |.....||...:|.:.:      :.:.|......|
Human   293 HVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTEADAGEYICKVSNYIGQANQSAWLTV 357

  Fly   189 RPSEHNPNG---------------YSLSV---------------------KDWEDGRGYHVKHYR 217
            .|.:..|..               |.:.|                     .|:......|....|
Human   358 LPKQQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKR 422

  Fly   218 IKPLDNGGYYIATNQTFPSLQALVMAYSKENA---LGLCHILSRPCPKPQPQM------WDLGPE 273
            | ||..              |..|.|.|..:.   ..|..|.:|........|      ::| ||
Human   423 I-PLRR--------------QVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYEL-PE 471

  Fly   274 LRDKYEIPRSEIQLLRKLGRGNFGEVFYG--------KWRNSIDVAVKTLREGT--MSTAAFLQE 328
             ..|:|.||.::.|.:.||.|.||:|...        |.:.::.||||.|::..  ...:..:.|
Human   472 -DPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSE 535

  Fly   329 AAIMKKF-RHNRLVALYAVCSQEEPIYIVQEYMSKGSLLDFLR--------------EGDGRYLH 378
            ..:||.. :|..::.|...|:|:.|:|::.||.|||:|.::||              ......:.
Human   536 MEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMT 600

  Fly   379 FEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKICDFGLARVIADDEYCPK-QGSR 442
            |:||:....|:|.|||||.|::.|||||||||||:.||||.||.||||||.|.:.:|..| ...|
Human   601 FKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGR 665

  Fly   443 FPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREVIENIERGFRMPKPTNHY 507
            .||||.||||:....::.:|||||:|:|:.|:||.|..||||:...|:.:.::.|.||.||.|
Human   666 LPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPAN-- 728

  Fly   508 FPDNIYQLLLQCWDAVPEKRPTFEFL 533
            ..:.:|.::..||.|||.:||||:.|
Human   729 CTNELYMMMRDCWHAVPSQRPTFKQL 754

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH2_Src_family	158..259	CDD:199827	24/148 (16%)
		PTKc_Src_like	289..538	CDD:270630	108/271 (40%)
		SH3_Src_like	99..150	CDD:212779	8/54 (15%)
FGFR2	NP_075259.4	IgI_1_FGFR	31..124	CDD:409362
		Ig strand A	31..34	CDD:409362
		Ig strand A'	47..53	CDD:409362
		Ig strand B	56..66	CDD:409362
		Ig strand C	69..74	CDD:409362
		Ig strand C'	77..79	CDD:409362
		Ig strand D	84..88	CDD:409362
		Ig strand E	91..96	CDD:409362
		Ig strand F	102..111	CDD:409362
		Ig strand G	114..124	CDD:409362
		IgI_2_FGFR	154..248	CDD:409443	13/57 (23%)
		Ig strand A	154..157	CDD:409443
		Ig strand A'	165..170	CDD:409443
		Ig strand B	174..182	CDD:409443
		Ig strand C	188..193	CDD:409443	172/611 (28%)
		Ig strand C'	196..198	CDD:409443	0/1 (0%)
		Ig strand D	207..210	CDD:409443	2/2 (100%)
		Ig strand E	214..219	CDD:409443	0/4 (0%)
		Ig strand F	228..235	CDD:409443	2/9 (22%)
		Ig strand G	238..248	CDD:409443	3/9 (33%)
		Ig	256..358	CDD:472250	21/128 (16%)
		Ig strand B	274..278	CDD:409353	1/7 (14%)
		Ig strand C	287..291	CDD:409353	0/3 (0%)
		Ig strand E	323..327	CDD:409353	1/3 (33%)
		Ig strand F	337..342	CDD:409353	0/4 (0%)
		Ig strand G	350..353	CDD:409353	1/2 (50%)
		PTKc_FGFR2	457..769	CDD:270679	117/302 (39%)