Protein Alignment Src64B and Yes1

DIOPT Version :10

• Sequence 1: NP_001286937.1
• Gene: Src64B / 48973
• FlyBaseID: FBgn0262733
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_033561.1
• Gene: Yes1 / 22612
• MGIID: 99147
• Length: 541
• Species: Mus musculus
• Alignment Length: 558
• Identity: 265/558 - (47%)
• Similarity: 360/558 - (64%)
• Gaps: 31/558 - (5%)

  Fly     1 MGNKCCSKRQDQELALAYP----TGGYKKSDYTFGQTH-----INSSGGGNMGGVLGQKHNNGGS 56
            ||  |...::::..|:.|.    |.....|...:|..|     .:|:.|.::         |..|
Mouse     1 MG--CIKSKENKSPAIKYTPENLTEPVSPSASHYGVEHATVAPTSSTKGASV---------NFNS 54

  Fly    57 LDSRYTPDPNHRGPLKIGGKGGVDIIRPRTTPTGVPGVVLKRVVVALYDYKSRDESDLSFMKGDR 121
            |.  .||.....|....||......:...:.|||:.|.|  .:.||||||::|...||||.||:|
Mouse    55 LS--MTPFGGSSGVTPFGGASSSFSVVSSSYPTGLTGGV--TIFVALYDYEARTTEDLSFKKGER 115

  Fly   122 MEVIDDTESDWWRVVNLTTRQEGLIPLNFVAEERSVNSEDWFFENVLRKEADKLLLAEENPRGTF 186
            .::|::||.|||...::.|.:.|.||.|:|....|:.:|:|:|..:.||:|::|||...|.||.|
Mouse   116 FQIINNTEGDWWEARSIATGKSGYIPSNYVVPADSIQAEEWYFGKMGRKDAERLLLNPGNQRGIF 180

  Fly   187 LVRPSEHNPNGYSLSVKDWEDGRGYHVKHYRIKPLDNGGYYIATNQTFPSLQALVMAYSKENALG 251
            |||.||.....||||::||::.||.:||||:|:.||||||||.|...|.:||.||..|: |:|.|
Mouse   181 LVRESETTKGAYSLSIRDWDEVRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHYT-EHADG 244

  Fly   252 LCHILSRPCPKPQPQMWDLGPELRDKYEIPRSEIQLLRKLGRGNFGEVFYGKWRNSIDVAVKTLR 316
            |||.|:..||..:||...|.   :|.:||||..::|..|||:|.||||:.|.|..:..||:|||:
Mouse   245 LCHKLTTVCPTVKPQTQGLA---KDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLK 306

  Fly   317 EGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQEEPIYIVQEYMSKGSLLDFLREGDGRYLHFED 381
            .|||...||||||.||||.||::||.||||.| |||||||.|:||||||||||:||||:||....
Mouse   307 PGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVS-EEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQ 370

  Fly   382 LIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKICDFGLARVIADDEYCPKQGSRFPVK 446
            |:.:|.|:|.||.|:|....|||||.|.|:|:|||.:.||.||||||:|.|:||..:||::||:|
Mouse   371 LVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKFPIK 435

  Fly   447 WTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREVIENIERGFRMPKPTNHYFPDN 511
            ||||||.:||:|:|||||||:|||..||.|.|:||||||.:|||:|.:|||:|||.|..  .|::
Mouse   436 WTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQG--CPES 498

  Fly   512 IYQLLLQCWDAVPEKRPTFEFLNHYFESFSVTSEVPYR 549
            :::|:..||...|::|||||::..:.|.:...:|..|:
Mouse   499 LHELMNLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQ 536

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH2_Src_family	158..259	CDD:199827	53/100 (53%)
		PTKc_Src_like	289..538	CDD:270630	147/248 (59%)
		SH3_Src_like	99..150	CDD:212779	24/50 (48%)
Yes1	NP_033561.1	SH3_Yes	92..149	CDD:212940	26/56 (46%)
		SH2_Src_family	152..251	CDD:199827	53/99 (54%)
		PTKc_Yes	262..540	CDD:270654	157/281 (56%)