Protein Alignment Src64B and FGFR3

DIOPT Version :10

• Sequence 1: NP_001286937.1
• Gene: Src64B / 48973
• FlyBaseID: FBgn0262733
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: XP_006713931.1
• Gene: FGFR3 / 2261
• HGNCID: 3690
• Length: 811
• Species: Homo sapiens
• Alignment Length: 603
• Identity: 174/603 - (28%)
• Similarity: 259/603 - (42%)
• Gaps: 146/603 - (24%)

  Fly    21 GGYK--KSDYTFGQTHINSSGGGNMGGVLGQKHNNGGSLDSRYTPDPNHRGPLKIGGKGGVDIIR 83
            ||.|  ...::.....:..|..||...|:   .|..||:...||.|...|.|.:...:.|:.
Human   202 GGIKLRHQQWSLVMESVVPSDRGNYTCVV---ENKFGSIRQTYTLDVLERSPHRPILQAGLP--- 260

  Fly    84 PRTTPTGVPGVVLKRVVVALYDYKSRDESDLSFMKGDRMEVIDDTES--DWWRVVNLTTRQEGLI 146
              ...|.|.|                  ||:.|    ..:|..|.:.  .|.:.|.:...:.|..
Human   261 --ANQTAVLG------------------SDVEF----HCKVYSDAQPHIQWLKHVEVNGSKVGPD 301

  Fly   147 PLNFVAEERSVNSEDWFFENVLRKEAD-KLLLAEENPR--GTFLVRPSEHNPNGYSLSVKD-WED 207
            ...:|...:|     |..|:|   ||| :|.||..:.|  |.:|.|.:    |...::.|. |..
Human   302 GTPYVTVLKS-----WISESV---EADVRLRLANVSERDGGEYLCRAT----NFIGVAEKAFWLS 354

  Fly   208 GRGYHVKHYRIKPLDNGGYYIATNQTFPSLQALVMAYS--------KENALGLCHILSRP----- 259
            ..|.......:...|..|          |:.|.:::|.        ...|:.||.:.|.|
Human   355 VHGPRAAEEELVEADEAG----------SVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLG 409

  Fly   260 ---------------------------CPKPQPQMWDL----GPELRD----------KYEIPRS 283
                                       ...|..::..|    ||.|.:          |:|:.|:
Human   410 SPTVHKISRFPLKRQVTVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRA 474

  Fly   284 EIQLLRKLGRGNFGEVFYG--------KWRNSIDVAVKTLREGT--MSTAAFLQEAAIMKKF-RH 337
            .:.|.:.||.|.||:|...        :....:.||||.|::..  ...:..:.|..:||.. :|
Human   475 RLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKH 539

  Fly   338 NRLVALYAVCSQEEPIYIVQEYMSKGSLLDFLR--------------EGDGRYLHFEDLIYIATQ 388
            ..::.|...|:|..|:|::.||.:||:|.:|||              :.....|.|:||:..|.|
Human   540 KNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQ 604

  Fly   389 VASGMEYLESKQLIHRDLAARNVLIGENNVAKICDFGLARVIADDEYCPK-QGSRFPVKWTAPEA 452
            ||.|||||.|::.|||||||||||:.|:||.||.||||||.:.:.:|..| ...|.||||.||||
Human   605 VARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEA 669

  Fly   453 IIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREVIENIERGFRMPKPTN--HYFPDNIYQL 515
            :....::.:|||||:|:||.|:||.|..||||:...|:.:.::.|.||.||.|  |    ::|.:
Human   670 LFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTH----DLYMI 730

  Fly   516 LLQCWDAVPEKRPTFEFL 533
            :.:||.|.|.:||||:.|
Human   731 MRECWHAAPSQRPTFKQL 748

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH2_Src_family	158..259	CDD:199827	26/112 (23%)
		PTKc_Src_like	289..538	CDD:270630	109/273 (40%)
		SH3_Src_like	99..150	CDD:212779	8/52 (15%)
FGFR3	XP_006713931.1	Ig	37..109	CDD:472250
		Ig strand B	57..61	CDD:409362
		Ig strand C	69..75	CDD:409362
		Ig strand E	92..96	CDD:409362
		IgI_2_FGFR	151..245	CDD:409443	12/45 (27%)
		Ig strand A	151..154	CDD:409443
		Ig strand A'	162..167	CDD:409443
		Ig strand B	171..179	CDD:409443
		Ig strand C	185..190	CDD:409443
		Ig strand C'	193..195	CDD:409443
		Ig strand D	204..207	CDD:409443	1/2 (50%)
		Ig strand E	211..216	CDD:409443	0/4 (0%)
		Ig strand F	225..232	CDD:409443	2/9 (22%)
		Ig strand G	235..245	CDD:409443	4/9 (44%)
		IgI_3_FGFR	253..354	CDD:409363	30/139 (22%)
		Ig strand A	253..256	CDD:409363	0/2 (0%)
		Ig strand A'	260..264	CDD:409363	0/8 (0%)
		Ig strand B	272..279	CDD:409363	2/10 (20%)
		Ig strand C	283..290	CDD:409363	1/6 (17%)
		Ig strand D	305..310	CDD:409363	1/4 (25%)
		Ig strand E	321..326	CDD:409363	1/4 (25%)
		Ig strand F	334..342	CDD:409363	3/11 (27%)
		Ig strand G	345..353	CDD:409363	1/7 (14%)
		Protein Kinases, catalytic domain	463..797	CDD:473864	113/290 (39%)