Protein Alignment Src64B and src-2

DIOPT Version :10

• Sequence 1: NP_001286937.1
• Gene: Src64B / 48973
• FlyBaseID: FBgn0262733
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_493502.1
• Gene: src-2 / 173296
• WormBaseID: WBGene00005078
• Length: 507
• Species: Caenorhabditis elegans
• Alignment Length: 526
• Identity: 220/526 - (41%)
• Similarity: 312/526 - (59%)
• Gaps: 42/526 - (7%)

  Fly    43 MGGVLGQKHNNGGSLDSRYTPD-------PNHR-----GPLKIGGKGGVDIIRPRTTPTGVPGVV 95
            ||..:|::....|:....:|..       |:|.     ||:.....|        .|......:.
 Worm     1 MGSCIGKEDPPPGATSPVHTSSTLGRESLPSHPRIPSIGPIAASSSG--------NTIDKNQNIS 57

  Fly    96 LKRVVVALYDYKSRDESDLSFMKGDRMEVIDDTESDWWRVVNLTTRQEGLIPLNFVAEERSVNSE 160
            .....|||:.|.:|.:.||||.|.|.:|:::||:.|||...:..|.:.|.||.|:||.|:|:.|:
 Worm    58 QSANFVALFQYDARTDDDLSFKKDDILEILNDTQGDWWFARHKATGRTGYIPSNYVAREKSIESQ 122

  Fly   161 DWFFENVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWEDGRGYHVKHYRIKPLDNGG 225
            .|:|..:.|.:|:|.||...|..|.||||.||...:..||||::.:.     ||||||:.||:||
 Worm   123 PWYFGKMRRIDAEKCLLHTLNEHGAFLVRDSESRQHDLSLSVRENDS-----VKHYRIRQLDHGG 182

  Fly   226 YYIATNQTFPSLQALVMAYSKENALGLCHILSRPCPKPQ-PQ----MWDLGPELRDKYEIPRSEI 285
            |:||..:.|.:|..|:..|.:| |.|||..|..||.|.: ||    .:|      |::|:.|..:
 Worm   183 YFIARRRPFATLHDLIAHYQRE-ADGLCVNLGAPCAKSEAPQTTTFTYD------DQWEVDRRSV 240

  Fly   286 QLLRKLGRGNFGEVFYGKWRNSIDVAVKTLREGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQE 350
            :|:|::|.|.||||:.|:|..::.||||.|:.||.....||.||.||||.||.:|::|||||:::
 Worm   241 RLIRQIGAGQFGEVWEGRWNVNVPVAVKKLKAGTADPTDFLAEAQIMKKLRHPKLLSLYAVCTRD 305

  Fly   351 EPIYIVQEYMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGE 415
            |||.||.|.|.: :||.||:. .||......|:.|:.|||:||.|||....|||||||||:||..
 Worm   306 EPILIVTELMQE-NLLTFLQR-RGRQCQMPQLVEISAQVAAGMAYLEEMNFIHRDLAARNILINN 368

  Fly   416 NNVAKICDFGLARVI-ADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQ 479
            :...||.||||||:: .::||..:.|:|||:|||||||..|.:|:.||||||:||||.|:.|:|:
 Worm   369 SLSVKIADFGLARILMKENEYEARTGARFPIKWTAPEAANYNRFTTKSDVWSFGILLTEIVTFGR 433

  Fly   480 VPYPGMHSREVIENIERGFRMPKPTNHYFPDNIYQLLLQCWDAVPEKRPTFEFLNHYFESFSVTS 544
            :|||||.:.||::.::.|:|||.|..  .|..:|.::.|||.:.|:||||||.|....|......
 Worm   434 LPYPGMTNAEVLQQVDAGYRMPCPAG--CPVTLYDIMQQCWRSDPDKRPTFETLQWKLEDLFNLD 496

  Fly   545 EVPYRE 550
            ...|:|
 Worm   497 SSEYKE 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH2_Src_family	158..259	CDD:199827	43/100 (43%)
		PTKc_Src_like	289..538	CDD:270630	127/249 (51%)
		SH3_Src_like	99..150	CDD:212779	21/50 (42%)
src-2	NP_493502.1	SH3_Src_like	61..112	CDD:212779	21/50 (42%)
		SH2_Src_Src42	120..215	CDD:198233	43/100 (43%)
		PTKc_Frk_like	231..496	CDD:270653	132/268 (49%)