Protein Alignment Src64B and Matk

DIOPT Version :10

• Sequence 1: NP_001286937.1
• Gene: Src64B / 48973
• FlyBaseID: FBgn0262733
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: XP_006513357.1
• Gene: Matk / 17179
• MGIID: 99259
• Length: 506
• Species: Mus musculus
• Alignment Length: 452
• Identity: 166/452 - (36%)
• Similarity: 247/452 - (54%)
• Gaps: 32/452 - (7%)

  Fly   113 DLSFMKGDRMEVIDDTE-SDWWRVVNLTTRQEGLIPLNFVAEERSVNSE------DWFFENVLRK 170
            :|:|.|||.:.:::..| ..|:|..:..:.||||:....:.:..:::::      .||...:..:
Mouse    65 ELAFRKGDMVTILEACEDKSWYRAKHHGSGQEGLLAAAALRQREALSTDPKLSLMPWFHGKISGQ 129

  Fly   171 EADKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWEDGRGYHVKHYRIKPLDNGGYYIATNQTFP 235
            ||.:.|...|:  |.||||.|..:|..|.|.|....|     |.|||:...| |...|.....|.
Mouse   130 EAIQQLQPPED--GLFLVRESARHPGDYVLCVSFGRD-----VIHYRVLHRD-GHLTIDEAVCFC 186

  Fly   236 SLQALVMAYSKENALGLCHILSRPCPKPQPQMWDLGPEL-RDKYEIPRSEIQLLRKLGRGNFGEV 299
            :|..:|..|:|:.. .:|..|.:|..|...:..:  .|| :..:.:....:.|..::|.|.||.|
Mouse   187 NLMDMVEHYTKDKG-AICTKLVKPRRKQGAKSAE--EELAKAGWLLDLQHLTLGAQIGEGEFGAV 248

  Fly   300 FYGKWRNSIDVAVKTLREGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQEEPIYIVQEYMSKGS 364
            ..|::... .||||.:: ..::..|||.|.|:|.|.:|..||.|..|. ....:|||.|::|||:
Mouse   249 LQGEYLGQ-KVAVKNIK-CDVTAQAFLDETAVMTKLQHRNLVRLLGVI-LHHGLYIVMEHVSKGN 310

  Fly   365 LLDFLREGDGRYLHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKICDFGLARV 429
            |::|||......:....|:..|..||.||||||||:|:||||||||:|:.|:.|||:.|||||:.
Mouse   311 LVNFLRTRGRALVSTSQLLQFALHVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKA 375

  Fly   430 IADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREVIENI 494
                |......||.|||||||||:..|:||.||||||:|:||.|:|:||:.|||.|..:||.|.:
Mouse   376 ----ERKGLDSSRLPVKWTAPEALKNGRFSSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAV 436

  Fly   495 ERGFRMPKPTNHYFPDNIYQLLLQCWDAVPEKRPTF----EFLNHYFESFSVTSEVPYREVQ 552
            |:|:||..|..  .|.:::.|:..||:|.|.:||.|    |.|.....|..|::....:|.:
Mouse   437 EKGYRMEPPDG--CPGSVHTLMGSCWEAEPARRPPFRKIVEKLGRELRSVGVSAPAGGQEAE 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH2_Src_family	158..259	CDD:199827	31/106 (29%)
		PTKc_Src_like	289..538	CDD:270630	115/252 (46%)
		SH3_Src_like	99..150	CDD:212779	12/37 (32%)
Matk	XP_006513357.1	SH3	49..107	CDD:473055	12/41 (29%)
		SH2_csk_like	117..214	CDD:198190	33/105 (31%)
		Protein Kinases, catalytic domain	227..480	CDD:473864	116/261 (44%)