Protein Alignment Src64B and fyn

DIOPT Version :10

• Sequence 1: NP_001286937.1
• Gene: Src64B / 48973
• FlyBaseID: FBgn0262733
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: XP_004914619.2
• Gene: fyn / 100488004
• XenbaseID: XB-GENE-6053489
• Length: 537
• Species: Xenopus tropicalis
• Alignment Length: 521
• Identity: 256/521 - (49%)
• Similarity: 349/521 - (66%)
• Gaps: 39/521 - (7%)

  Fly    30 FGQTHINSSGGGNM-GGVLGQKHNNGGSLDSRYTPDPNHRGPLKIGGKGGVDIIRPRTTPTGVPG 93
            :...|.|:..|..: |||      |..|          |.|.|:..|..||.:.
 Frog    50 YNNFHTNAGQGLTVFGGV------NSSS----------HTGTLRTRGGTGVTLF----------- 87

  Fly    94 VVLKRVVVALYDYKSRDESDLSFMKGDRMEVIDDTESDWWRVVNLTTRQEGLIPLNFVAEERSVN 158
                   ||||||::|.|.||||.||::.::::.:|.|||...:|||...|.||.|:||...|:.
 Frog    88 -------VALYDYEARTEDDLSFQKGEKFQILNSSEGDWWEARSLTTGGTGYIPSNYVAPVDSIQ 145

  Fly   159 SEDWFFENVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWEDGRGYHVKHYRIKPLDN 223
            :|:|:|..:.||:|::.||:..|||||:|:|.||.....||||::||:|.:|.|||||:|:.|||
 Frog   146 AEEWYFGKLGRKDAERQLLSFGNPRGTYLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDN 210

  Fly   224 GGYYIATNQTFPSLQALVMAYSKENALGLCHILSRPCPKPQPQMWDLGPELRDKYEIPRSEIQLL 288
            |||||.|...|.:||.||..|| |.|.|||..|..||.|..|::.||..:.:|.:||||..:||:
 Frog   211 GGYYITTRAQFETLQQLVQHYS-ERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLI 274

  Fly   289 RKLGRGNFGEVFYGKWRNSIDVAVKTLREGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQEEPI 353
            ::||.|.||||:.|.|..:..||:|||:.||||..:||:||.||||.:|::||.||||.| ||||
 Frog   275 KRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVS-EEPI 338

  Fly   354 YIVQEYMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNV 418
            |||.||||||||||||::|:||.|...:|:.:|.|||:||.|:|....|||||.:.|:|:|...:
 Frog   339 YIVTEYMSKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLI 403

  Fly   419 AKICDFGLARVIADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYP 483
            .||.||||||:|.|:||..:||::||:|||||||.:||:|:|||||||:||||.||.|.|:||||
 Frog   404 CKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYP 468

  Fly   484 GMHSREVIENIERGFRMPKPTNHYFPDNIYQLLLQCWDAVPEKRPTFEFLNHYFESFSVTSEVPY 548
            ||::|||:|.:|||:|||.|.:  .|:::::|:|.||...||:|||||:|..:.|.:...:|..|
 Frog   469 GMNNREVLEQVERGYRMPCPQD--CPNSLHELMLNCWKKDPEERPTFEYLQGFLEDYFTATEPQY 531

  Fly   549 R 549
            :
 Frog   532 Q 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH2_Src_family	158..259	CDD:199827	53/100 (53%)
		PTKc_Src_like	289..538	CDD:270630	145/248 (58%)
		SH3_Src_like	99..150	CDD:212779	24/50 (48%)
fyn	XP_004914619.2	SH3_Fyn_Yrk	85..140	CDD:212939	26/72 (36%)
		SH2_Src_Fyn_isoform_a_like	145..245	CDD:198281	53/100 (53%)
		PTKc_Fyn	261..534	CDD:270655	155/275 (56%)