Protein Alignment Src64B and srms

DIOPT Version :10

• Sequence 1: NP_001286937.1
• Gene: Src64B / 48973
• FlyBaseID: FBgn0262733
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_001129722.2
• Gene: srms / 100192213
• ZFINID: ZDB-GENE-081022-95
• Length: 492
• Species: Danio rerio
• Alignment Length: 480
• Identity: 183/480 - (38%)
• Similarity: 293/480 - (61%)
• Gaps: 39/480 - (8%)

  Fly    77 GGVDIIRPRTTPTGVPGVVLKRVVVALYDYKSRDESDLSFMKGDRMEVIDDTESDWWRVVNLT-T 140
            |.:.:..|:..|.        ::..||:|:.:|.|.:||..:||::.|| :...|:.....|| :
Zfish    38 GDIRVPAPKKKPA--------QLYAALFDFVARSEEELSVKEGDKLSVI-EKRGDYVFAKKLTGS 93

  Fly   141 RQEGLIPLNFVA--EERSVNSEDWFFENVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSVK 203
            .:.||||.|:||  ::...|.: |::.|:.|::|:||||:.||..|:||||.||.:.:.|::|.:
Zfish    94 LESGLIPANYVALLKDEFANYK-WYYGNINRQKAEKLLLSSENKTGSFLVRISESHSDEYTISAR 157

  Fly   204 DWEDGRGYHVKHYRIKPLDNGGYYIATNQTFPSLQALVMAYSKEN-ALGLCHILSRPCPKPQPQM 267
            ....     |.|:||.....|.|:::...:|.:|..|:..|.:.: :|| ||| .:||.: :.::
Zfish   158 SENS-----VFHFRIHRSPIGAYFVSEKISFGTLDELIRYYQQNSRSLG-CHI-DQPCVQ-RREL 214

  Fly   268 WDLGPELRDKYEIPRSEIQLLRKLGRGNFGEVFYGKWR-NSIDVAVKTLREGTMSTAAFLQEAAI 331
            :|:.|     :|.||.|..|::|||.|:||||:...|: ....||:|.|::.......|::|...
Zfish   215 FDMEP-----WERPREEFMLVKKLGEGHFGEVWEAIWKTQKKKVAIKMLKQEDTKLDEFVKEVHA 274

  Fly   332 MKKFRHNRLVALYAVCSQEEPIYIVQEYMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYL 396
            :|...|.:|:.|.|:||:.||:|||.|.|:||||..:|...:|:.|....|||:|.|:|.||.||
Zfish   275 LKNLHHPKLIELLALCSRGEPVYIVTELMAKGSLKSYLSSAEGQLLTSAHLIYMAAQIAEGMAYL 339

  Fly   397 ESKQLIHRDLAARNVLIGENNVAKICDFGLARVIADDEYCPKQGSRFPVKWTAPEAIIYGKFSIK 461
            |.:.::||||||||:|:|.:.|.|:.||||||:|.|..:...:.::.||:||||||.:|.:||:|
Zfish   340 EDRHIVHRDLAARNILVGNDLVCKVADFGLARIIKDSVFTASKTTKIPVRWTAPEAALYQRFSVK 404

  Fly   462 SDVWSYGILLMELFTYGQVPYPGMHSREVIENIERGFRMPKPTNHYFPDNIYQLLLQCWDAVPEK 526
            |||||:|:||.|:.:.|::||.|..::||:|.:..|:|:..| || .|.|||:::|:||:....|
Zfish   405 SDVWSFGVLLYEMMSRGKMPYDGKTNKEVMEALSSGYRLACP-NH-CPPNIYRIMLECWNNEASK 467

  Fly   527 RPTFEFLNH---------YFESFSV 542
            ||:|..|:.         ||::..|
Zfish   468 RPSFHALHSQLDNIYSRLYFKTIEV 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Src64B	NP_001286937.1	SH2_Src_family	158..259	CDD:199827	35/101 (35%)
		PTKc_Src_like	289..538	CDD:270630	113/258 (44%)
		SH3_Src_like	99..150	CDD:212779	18/51 (35%)
srms	NP_001129722.2	SH3	52..106	CDD:473055	20/54 (37%)
		SH2	116..193	CDD:425423	28/81 (35%)
		Protein Kinases, catalytic domain	220..481	CDD:473864	117/262 (45%)