Protein Alignment Atpalpha and ENA2

DIOPT Version :10

• Sequence 1: NP_732572.1
• Gene: Atpalpha / 48971
• FlyBaseID: FBgn0002921
• Length: 1041
• Species: Drosophila melanogaster
• Sequence 2: NP_010324.3
• Gene: ENA2 / 851609
• SGDID: S000002446
• Length: 1091
• Species: Saccharomyces cerevisiae
• Alignment Length: 1149
• Identity: 325/1149 - (28%)
• Similarity: 492/1149 - (42%)
• Gaps: 274/1149 - (23%)

  Fly    61 FHKISPEELYQRFQTHPENGLSHAKAKENLERDGPNALTPPKQTPEWVKFCKNLFGGFAMLLWIG 125
            :|.::.||..:...|....||:..::...|:..|.|.|....:..........:.....|:|.|.
Yeast    17 YHTLTTEEAAEFIGTSLTEGLTQDESLRRLKAVGENTLGDDTKIDYKAMVLHQVCNAMIMVLVIS 81

  Fly   126 AILCFVAYSIQASTSEEPADDNLYLGIVLSAVVIVTGIFSYYQESKSSKIMESFKNMVPQFATVI 190
            ..:.|             |..:...|.|:|.|:.|..:....||.|::|.|.|.||:....|.||
Yeast    82 MAISF-------------AVRDWITGGVISFVIAVNVLIGLVQEYKATKTMNSLKNLSSPNAHVI 133

  Fly   191 REGEKLTLRAEDLVLGDVVEVKFGDRIPADIRIIEARNFKVDNSSLTGESEPQSRGAEFTHENPL 255
            |.|:..|:.::|:|.||:..||.||.||||:|:||.:||..|.|.|||||.|.|:.|........
Yeast   134 RNGKSETINSKDVVPGDICLVKVGDTIPADLRLIETKNFDTDESLLTGESLPVSKDANLVFGKEE 198

  Fly   256 ETK-----NLAFFSTNAVEGTAKGVVISCGDHTVMGRIA-------GLAS--------------- 293
            ||.     ||||.|:..|:|.|||:||....::.:|:||       ||.|
Yeast   199 ETSVGDRLNLAFSSSAVVKGRAKGIVIKTALNSEIGKIAKSLQGDSGLISRDPSKSWLQNTWIST 263

  Fly   294 --------GLDTGETPIAKEIHHFIHLITGVAVFLGVTFFVIAFILGYHWLD----AVIFLIGII 346
                    |.:.| ||:.:::.....|:..:||...:      .::.....|    ..|:.|.:.
Yeast   264 KKVTGAFLGTNVG-TPLHRKLSKLAVLLFWIAVLFAI------IVMASQKFDVDKRVAIYAICVA 321

  Fly   347 VANVPEGLLATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMW- 410
            ::.:|..|:..:|:.:::.|..|.|:|.:|:.|:::|.||:.:.|||||||||||.:|....:|
Yeast   322 LSMIPSSLVVVLTITMSVGAAVMVSRNVIVRKLDSLEALGAVNDICSDKTGTLTQGKMLARQIWI 386

  Fly   411 ----------------------------------------------FDNQIIEADTTEDQSGVQY 429
                                                          |.:::.|.|..||   :..
Yeast   387 PRFGTITISNSDDPFNPNEGNVSLIPRFSPYEYSHNEDGDVGILQNFKDRLYEKDLPED---IDM 448

  Fly   430 DRTSPGFKALSRIATLCNRAE-FKGGQDGVPILKKEVSGDASEAAL---LKCMEL---AL----- 482
            |.    |:.....|||.|.|. ||  .|.....|  ..||.:|.|:   ...|:|   ||
Yeast   449 DL----FQKWLETATLANIATVFK--DDATDCWK--AHGDPTEIAIQVFATKMDLPHNALTGEKS 505

  Fly   483 ------GDVMNIRKRNKK--------IAEVPFNSTNKYQVSIHETEDTNDPRYLLVMKGAPERIL 533
                  .|..::.:.|:|        |||.||:||.|...|::  .:.::..|.:..|||.|.|:
Yeast   506 TNQSNENDQSSLSQHNEKPGSAQFEHIAEFPFDSTVKRMSSVY--YNNHNETYNIYGKGAFESII 568

  Fly   534 ERCSTIFINGKEKV-----LDEEMKEAFNNAYMELGGLGERVLGFCDFMLPSDKYPNGFKFNTDD 593
            ..||:.:  ||:.|     .|.:::....|.| .|...|.|||||.......|      :.|.|.
Yeast   569 SCCSSWY--GKDGVKITPLTDCDVETIRKNVY-SLSNEGLRVLGFASKSFTKD------QVNDDQ 624

  Fly   594 INFPIDN-------LRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKSVGI 651
            :.....|       |.|:||:.:.||||.....||.|...|||.|.|:|||...||||||:.|||
Yeast   625 LKNITSNRATAESDLVFLGLIGIYDPPRNETAGAVKKFHQAGINVHMLTGDFVGTAKAIAQEVGI 689

  Fly   652 ISE-----GNETVEDIAQRLNIPVSEVNPREAKAAVVHGAELRDVSSDQLDE--ILRYHTEIVFA 709
            :..     ..|.|:.:                   |:.|::...:|.:::|:  :|    .:|.|
Yeast   690 LPTNLYHYSQEIVDSM-------------------VMTGSQFDGLSEEEVDDLPVL----PLVIA 731

  Fly   710 RTSPQQKLIIVEGCQRMGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFA 774
            |.|||.|:.::|...|.....|:|||||||||:||.|::|:||||.||||||:|:|::|.|||||
Yeast   732 RCSPQTKVRMIEALHRRKKFCAMTGDGVNDSPSLKMANVGIAMGINGSDVSKEASDIVLSDDNFA 796

  Fly   775 SIVTGVEEGRLIFDNLKKSIAYTLTSNIPE-ISPFLAFILCD----IPLPLGTVTILCIDLGTDM 834
            ||:..|||||.:.||::|.:...|..|:.: :...:..:..|    ...||..|.:|.|.:.|..
Yeast   797 SILNAVEEGRRMTDNIQKFVLQLLAENVAQALYLIIGLVFRDENGKSVFPLSPVEVLWIIVVTSC 861

  Fly   835 VPAISLAYEHAEADIMKRPPRDPFNDKLVNSRLISMAYGQIGMI--QAAAGFFVYFVIMAEN--G 895
            .||:.|..|.|..|:|.|||.|                .::|:.  :.....|.|.:||..:  .
Yeast   862 FPAMGLGLEKAAPDLMDRPPHD----------------SEVGIFTWEVIIDTFAYGIIMTGSCMA 910

  Fly   896 FLPKKLFGIRKMWDSKAVNDLTDSYGQEW--TYRDRKTLEYTCHTAFFISIVVVQWADLI----I 954
            .....|:||.   ..:..:|...:|....  .||.|..           :...:.|..||    :
Yeast   911 SFTGSLYGIN---SGRLGHDCDGTYNSSCRDVYRSRSA-----------AFATMTWCALILAWEV 961

  Fly   955 CKTRRN-----------------SIFQQGMRNWALNFGLVFETVLAAF-LSYCPGMEKGLRMY-P 1000
            ...||:                 ||:......|::.||.|     :|| :.|.|.:...:.:: |
Yeast   962 VDMRRSFFRMHPDTDSPVKEFFRSIWGNQFLFWSIIFGFV-----SAFPVVYIPVINDKVFLHKP 1021

  Fly  1001 LKLVWWFPAIPFALAIFI----YDETRRFYLR----RNPGGWLE 1036
            :...|.. ||.|.:|.:|    |...:|.|.:    .||...||
Yeast  1022 IGAEWGL-AIAFTIAFWIGAELYKCGKRRYFKTQRAHNPENDLE 1064

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	325/1149 (28%)
ENA2	NP_010324.3	ATPase-IID_K-Na	11..1055	CDD:130586	321/1138 (28%)