DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atpalpha and atp1a1a.3

DIOPT Version :9

Sequence 1:	NP_732572.1	Gene:	Atpalpha / 48971	FlyBaseID:	FBgn0002921	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	NP_571763.1	Gene:	atp1a1a.3 / 64614	ZFINID:	ZDB-GENE-001212-3	Length:	1024	Species:	Danio rerio

Alignment Length:	1029	Identity:	744/1029 - (72%)
Similarity:	878/1029 - (85%)	Gaps:	12/1029 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 DSYRVATVIATDDDNRTADGQYKSRRKMPAKVNKKENLDDLKQELDIDFHKISPEELYQRFQTHP 77
            |.|::|   ||.:     ||..|.::   .|.|||: :|:||:|:::|.||::.|||.:::.|..
Zfish     8 DEYKLA---ATSE-----DGVKKPKK---GKKNKKD-MDELKKEVEMDDHKLTLEELSRKYGTDL 60

  Fly    78 ENGLSHAKAKENLERDGPNALTPPKQTPEWVKFCKNLFGGFAMLLWIGAILCFVAYSIQASTSEE 142
            ..|||..:|||.|.||||||||||..||||||||:.|||||..||||||:|||.||||||::.||
Zfish    61 NKGLSITRAKEILARDGPNALTPPVTTPEWVKFCRQLFGGFQTLLWIGALLCFFAYSIQAASEEE 125

  Fly   143 PADDNLYLGIVLSAVVIVTGIFSYYQESKSSKIMESFKNMVPQFATVIREGEKLTLRAEDLVLGD 207
            ||:||||||:||:.||.|.|.||||||:|||:||:||:|:|||.|.|:|||||..:.|||:|:||
Zfish   126 PANDNLYLGLVLAFVVTVNGCFSYYQEAKSSRIMDSFRNLVPQKALVVREGEKSVIDAEDVVVGD 190

  Fly   208 VVEVKFGDRIPADIRIIEARNFKVDNSSLTGESEPQSRGAEFTHENPLETKNLAFFSTNAVEGTA 272
            :||||.||||||||||:.::..||||||||||||||:|..|.:.:|||||:|:||||||.|:|.|
Zfish   191 LVEVKGGDRIPADIRIVSSQGCKVDNSSLTGESEPQTRAPEMSSDNPLETRNIAFFSTNCVDGAA 255

  Fly   273 KGVVISCGDHTVMGRIAGLASGLDTGETPIAKEIHHFIHLITGVAVFLGVTFFVIAFILGYHWLD 337
            :|||::.||.|||||||.|||.|:.|:||||:||.||||:|||||||||:||.|::.||||:||:
Zfish   256 RGVVVNTGDRTVMGRIASLASSLEGGQTPIAREIEHFIHIITGVAVFLGLTFLVLSLILGYNWLE 320

  Fly   338 AVIFLIGIIVANVPEGLLATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQN 402
            .||||||||||||||||.|||||||||||||||.|||||||||||||||||:|||||||||||||
Zfish   321 GVIFLIGIIVANVPEGLPATVTVCLTLTAKRMAKKNCLVKNLEAVETLGSTTTICSDKTGTLTQN 385

  Fly   403 RMTVAHMWFDNQIIEADTTEDQSGVQYDRTSPGFKALSRIATLCNRAEFKGGQDGVPILKKEVSG 467
            |||||||||||.|..|||||:|:|..:||:|..:.||:|:|.|||||.|:..|..:|:||::.:|
Zfish   386 RMTVAHMWFDNHIHIADTTENQTGASFDRSSATWSALARVAGLCNRAVFQSNQSHIPVLKRDTAG 450

  Fly   468 DASEAALLKCMELALGDVMNIRKRNKKIAEVPFNSTNKYQVSIHETEDTNDPRYLLVMKGAPERI 532
            ||||:|||||:||:.|.|..:|:...|:||:|||||||||||||:..::::|::|||||||||||
Zfish   451 DASESALLKCIELSCGSVAEMRENYTKLAEIPFNSTNKYQVSIHKNPNSSEPKHLLVMKGAPERI 515

  Fly   533 LERCSTIFINGKEKVLDEEMKEAFNNAYMELGGLGERVLGFCDFMLPSDKYPNGFKFNTDDINFP 597
            |||||||||.|||:.:|:|||:||.|||:|||||||||||||.|.||.|::|.||.|:|:::|||
Zfish   516 LERCSTIFIQGKEQPMDDEMKDAFQNAYLELGGLGERVLGFCHFCLPDDQFPEGFAFDTEEMNFP 580

  Fly   598 IDNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNETVEDI 662
            .:||.|||||||||||||||||||||||||||||||||||||||||||||.|||||||||||:||
Zfish   581 TENLCFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVDDI 645

  Fly   663 AQRLNIPVSEVNPREAKAAVVHGAELRDVSSDQLDEILRYHTEIVFARTSPQQKLIIVEGCQRMG 727
            |.||.|.:.|||||:|||.|:||.||::::.:|||::|::|||||||||||||||||||||||.|
Zfish   646 AARLKIHIDEVNPRDAKACVIHGGELKNMTDEQLDDVLQHHTEIVFARTSPQQKLIIVEGCQRQG 710

  Fly   728 AIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKK 792
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   711 AIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKK 775

  Fly   793 SIAYTLTSNIPEISPFLAFILCDIPLPLGTVTILCIDLGTDMVPAISLAYEHAEADIMKRPPRDP 857
            ||||||||.|||:||||.|:|..||||||||||||||||||||||||||||.||:|||||.||:.
Zfish   776 SIAYTLTSKIPEMSPFLMFVLVGIPLPLGTVTILCIDLGTDMVPAISLAYETAESDIMKRQPRNA 840

  Fly   858 FNDKLVNSRLISMAYGQIGMIQAAAGFFVYFVIMAENGFLPKKLFGIRKMWDSKAVNDLTDSYGQ 922
            ..|:|||.||||::|||||||||..|||.||||:|||||||..|.|||..|:.:.:|||.|||||
Zfish   841 ATDRLVNERLISVSYGQIGMIQAVGGFFTYFVILAENGFLPYDLVGIRVGWEDRFLNDLEDSYGQ 905

  Fly   923 EWTYRDRKTLEYTCHTAFFISIVVVQWADLIICKTRRNSIFQQGMRNWALNFGLVFETVLAAFLS 987
            :|||..||.:|||||||||.|||:|||.||:||||||.|||||||:|..|.|||:.||.||||||
Zfish   906 QWTYESRKIVEYTCHTAFFASIVIVQWTDLLICKTRRLSIFQQGMKNRVLTFGLLEETALAAFLS 970

  Fly   988 YCPGMEKGLRMYPLKLVWWFPAIPFALAIFIYDETRRFYLRRNPGGWLEQETYY 1041
            ||||||..:||||||.:|||.|.|::|.||||||.|::.||||||||:|:||||
Zfish   971 YCPGMEVAVRMYPLKPLWWFCAFPYSLLIFIYDEVRKYILRRNPGGWVERETYY 1024

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	733/995 (74%)
		Cation_ATPase_N	58..132	CDD:214842	46/73 (63%)
		E1-E2_ATPase	152..383	CDD:278548	167/230 (73%)
		Cation_ATPase	445..539	CDD:289987	58/93 (62%)
		COG4087	<695..770	CDD:226572	69/74 (93%)
		Cation_ATPase_C	817..1025	CDD:279079	153/207 (74%)
atp1a1a.3	NP_571763.1	ATPase-IIC_X-K	32..1024	CDD:273445	730/992 (74%)
		Cation_ATPase_N	41..115	CDD:214842	46/73 (63%)
		E1-E2_ATPase	135..366	CDD:278548	167/230 (73%)
		Cation_ATPase	428..522	CDD:289987	58/93 (62%)
		COG4087	604..753	CDD:226572	126/148 (85%)
		Cation_ATPase_C	800..1009	CDD:279079	153/208 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	457	1.000	Domainoid score	I475
eggNOG	1	0.900	-	-		E2759_KOG0203
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1592	1.000	Inparanoid score	I79
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D388324at2759
OrthoFinder	1	1.000	-	-		FOG0000283
OrthoInspector	1	1.000	-	-		otm24672
orthoMCL	1	0.900	-	-		OOG6_100215
Panther	1	1.100	-	-	O	PTHR43294
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X416
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.840