DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mtr4 and MTR4

DIOPT Version :9

Sequence 1:	NP_524929.1	Gene:	Mtr4 / 48782	FlyBaseID:	FBgn0001986	Length:	1055	Species:	Drosophila melanogaster
Sequence 2:	NP_176185.1	Gene:	MTR4 / 842269	AraportID:	AT1G59760	Length:	988	Species:	Arabidopsis thaliana

Alignment Length:	995	Identity:	486/995 - (48%)
Similarity:	682/995 - (68%)	Gaps:	40/995 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 DNNADDEPTRTLDIDDSATLEALRTRIVTHLLDAPKSCTHEVAAHPDQEYIPLKP--FSGVPAKE 147
            :.::|..|.:.:..:|.:| :.:...:|        .|.|:|:.  .:.|:||.|  .:..|||:
plant    10 EESSDSAPPQKVQREDDST-QIINEELV--------GCVHDVSF--PENYVPLAPSVHNKPPAKD 63

  Fly   148 YPFVLDPFQRQAILCIDNSQSVLVSAHTSAGKTVVAEYAIAKSLAAKQRVIYTTPIKALSNQKFR 212
            :||.||.||.:||.|:||.:||:|||||||||||||.||||.||...||||||:|||||||||:|
plant    64 FPFTLDSFQSEAIKCLDNGESVMVSAHTSAGKTVVASYAIAMSLKENQRVIYTSPIKALSNQKYR 128

  Fly   213 EFTDEFKDVGLVTGDVTINPSASCLIMTTEILRNMLYRGSEIMREVGWVVFDEIHYMRDKERGVV 277
            :|.:||.||||:||||||:|:||||:|||||||:|.|:||||||||.|::|||:|||||.|||||
plant   129 DFKEEFSDVGLMTGDVTIDPNASCLVMTTEILRSMQYKGSEIMREVAWIIFDEVHYMRDSERGVV 193

  Fly   278 WEETLILLPDNVRYVFLSATIPNARQFAEWVCHLHKQPCHVVYTDYRPTPLQHYIFPAGGDGIHL 342
            |||::::.|.|.|:||||||:|||::||:||..:|:||||:|||||||||||||:|||||:|::|
plant   194 WEESIVMAPKNSRFVFLSATVPNAKEFADWVAKVHQQPCHIVYTDYRPTPLQHYVFPAGGNGLYL 258

  Fly   343 IVDEKGQFKEDNFTTAMAVLANAGEAGKGDQKGR--HGGIKGTNAGQTNIFKIVKMIMERNFAPV 405
            :||||.:|.||:|..::..|....|:.|....|:  .|.:.|....:::|||:||||::|.:.||
plant   259 VVDEKSKFHEDSFQKSLNALVPTNESDKKRDNGKFQKGLVIGKLGEESDIFKLVKMIIQRQYDPV 323

  Fly   406 IIFSFSKKDCEIYAMQMAKLDFNTPDEKKLVDEVFNNAMDVLTEEDRRLPQVENVLPLLRRGIGI 470
            |:||||||:||..||||:|:..|:.|||..|:.:|.:|:|:|:::|::||||.|:||:|:||||:
plant   324 ILFSFSKKECEALAMQMSKMVLNSDDEKDAVETIFASAIDMLSDDDKKLPQVSNILPILKRGIGV 388

  Fly   471 HHGGLLPILKETIEILFGEGLIKALFATETFAMGLNMPARTVLFTAPRKFDGKKFRWISSGEYIQ 535
            ||.||||||||.|||||.|||||.|||||||::||||||:||:||..|||||.||||:|||||||
plant   389 HHSGLLPILKEVIEILFQEGLIKCLFATETFSIGLNMPAKTVVFTNVRKFDGDKFRWLSSGEYIQ 453

  Fly   536 MAGRAGRRGLDDKGIVILMIDEKVSPAVGRDIVQGKADPINSAFHLTYNMVLNLLRVEEINPEYM 600
            |:|||||||:|.:||.|||:|||:.|||.:.:::|.||.:||||||:|||:||.||.||.:||.:
plant   454 MSGRAGRRGIDKRGICILMVDEKMEPAVAKSMLKGSADSLNSAFHLSYNMLLNQLRCEEGDPENL 518

  Fly   601 LERSFYQFQNQAALPGLHDQVEQKTLELNKLTIKDEHNIASYHHIRSQLDQHGKQFRQWITKPQY 665
            |..||:|||...|:|.|..|::....|.:.|.|::|.::.:|:::..|.....|..|:.:..|:|
plant   519 LRNSFFQFQADRAIPDLEKQIKSLEEERDSLVIEEEESLKNYYNLILQYKSLKKDIREIVFTPKY 583

  Fly   666 LLPFLQPGRLVKVAAGSQEYD-----------WGIVLNFKK-----QDQSRKNPLKAEPSVTIDV 714
            .||||.|.|.|.:...:.:.:           ||:::.|.|     :|...:.|  .:.:.|:||
plant   584 CLPFLLPNRAVCLDCTNDDEEPQSFSIEDQDTWGVIMKFNKVKSLSEDDDSRRP--EDANYTVDV 646

  Fly   715 LLHVSEAAAKTGDTE----PCKPNERGCMEVVPVAHTLITQISSIRVYFPNDLRSADNRRAVLKT 775
            |.....:....|..:    |.|  |||...||.|..:.|..:||..:..|.||...:.|...||.
plant   647 LTRCMVSKDGVGKKKVKAVPIK--ERGEPVVVTVPLSQIKSLSSAIMNIPKDLVPLEARENALKK 709

  Fly   776 IQEAKKRFPLGPPVLNPIDDMNIKDREFRDIVNTISQFEKRLEEHPLHKSPELERIHRRYQDKVT 840
            :.|...|.|.|.| |:|..||.||...::..|..:...|...|:|.:.|||.:....:..|.|..
plant   710 VSELLSRHPDGIP-LDPEVDMKIKSSSYKKTVRRLEALENLFEKHKIAKSPLITEKLKVLQMKEE 773

  Fly   841 LQKQLQDLKAELKAARSLLQMDELKHRKRVLRRMGYCKPGDVIEFKGRVACELSSADELLMTEMI 905
            |..:::.||..::::.:|...||||.|||||||:||....:|:|.||:||||:|||:||.:||::
plant   774 LIAKIKSLKKTVRSSTALAFKDELKARKRVLRRLGYITSDNVVELKGKVACEISSAEELTLTELM 838

  Fly   906 FNGVFNDLTAPQAVALLSCFVCDEKSSESVKSATELSGPLRSMQDLARRIAKVSTECKLDLDADT 970
            |:|:|.|....:.|:||||||..|:..::.|...||......:||.|||:|:|..:||:::|.::
plant   839 FSGIFKDAKVEELVSLLSCFVWRERLPDAAKPREELDLLFIQLQDTARRVAEVQLDCKVEIDVES 903

  Fly   971 YVDKFKPFLMDVVLAWCKGSSFLAVCKMTDIFEGSIIRCMRRLEELLRQMCQASKTIGNTDLENK 1035
            :|..|:|.:|:.|.||.|||.|..|.::..:||||:||.:||:||:|:|:..|:|:||.|.||.|
plant   904 FVQSFRPDIMEAVYAWAKGSKFYEVMEIARVFEGSLIRAIRRMEEVLQQLIVAAKSIGETQLEAK 968

  Fly  1036 FSEGIRLLKRDIVFAASLYL 1055
            ..|.:..:||||||||||||
plant   969 LEEAVSKIKRDIVFAASLYL 988

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mtr4	NP_524929.1	Dob10	91..1055	CDD:226947	483/987 (49%)
		DEAD	154..299	CDD:278688	105/144 (73%)
		HELICc	390..554	CDD:238034	111/163 (68%)
		rRNA_proc-arch	600..853	CDD:289976	78/272 (29%)
		DSHCT	881..1048	CDD:285374	76/166 (46%)
MTR4	NP_176185.1	Dob10	40..988	CDD:226947	478/954 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	230	1.000	Domainoid score	I657
eggNOG	1	0.900	-	-		E1_COG4581
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6257
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53687
OrthoDB	1	1.010	-	-		D176060at2759
OrthoFinder	1	1.000	-	-		FOG0003580
OrthoInspector	1	1.000	-	-		oto3007
orthoMCL	1	0.900	-	-		OOG6_100340
Panther	1	1.100	-	-	O	PTHR12131
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2451
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.790