Protein Alignment Mtr4 and skic2

DIOPT Version :10

• Sequence 1: NP_524929.1
• Gene: Mtr4 / 48782
• FlyBaseID: FBgn0001986
• Length: 1055
• Species: Drosophila melanogaster
• Sequence 2: XP_073787022.1
• Gene: skic2 / 559653
• ZFINID: ZDB-GENE-010430-5
• Length: 1250
• Species: Danio rerio
• Alignment Length: 1139
• Identity: 390/1139 - (34%)
• Similarity: 578/1139 - (50%)
• Gaps: 191/1139 - (16%)

  Fly     1 MDIEELFDCFDEVTPSVPP--------------PALNQEE----KPSGSSASKKGNKRQADGTTA 47
            :::..|...||:|..:.|.              |..|..|    |.||||        |..|.|
Zfish   216 VNLLSLLSTFDDVLDAPPEDKEGVSQKEEIVKLPRTNSLEDLGIKDSGSS--------QPQGNT- 271

  Fly    48 SKEATSSKGAEGDDKGDVTEEPTKRLKQEASTVAVDDDNNADDEPTRTLDIDDSATLEALRTRIV 112
                           |.:||:..|.|::|..           |.....:.:|.|:.......||
Zfish   272 ---------------GSLTEQKKKNLEEEKG-----------DNKKWAIPVDISSPCADFYKRI- 309

  Fly   113 THLLDAPKSCTHEVAAHPDQEYIPLKPFSGVPAKEYPFVLDPFQRQAILCIDNSQSVLVSAHTSA 177
                             ||            ||.:|||.||.||:||||.::...||.|:|||||
Zfish   310 -----------------PD------------PAFKYPFELDVFQKQAILRLEAHDSVFVAAHTSA 345

  Fly   178 GKTVVAEYAIAKSLAAKQRVIYTTPIKALSNQKFREFTDEFKDVGLVTGDVTINPSASCLIMTTE 242
            |||||||||||.|.....|.|||:|||||||||||:|.:.|.||||:||||.:||..||||||||
Zfish   346 GKTVVAEYAIALSQKHMTRTIYTSPIKALSNQKFRDFKNTFGDVGLLTGDVQLNPEGSCLIMTTE 410

  Fly   243 ILRNMLYRGSEIMREVGWVVFDEIHYMRDKERGVVWEETLILLPDNVRYVFLSATIPNARQFAEW 307
            |||:|||.|||::|::.||:|||:||:.|.||||||||.||:||::|..:.||||:|||.:|:||
Zfish   411 ILRSMLYNGSEVIRDLEWVIFDEVHYINDAERGVVWEEVLIMLPEHVSIILLSATVPNAVEFSEW 475

  Fly   308 VCHLHKQPCHVVYTDYRPTPLQHYIFPAGG----DGIHLIVDEKGQFKEDNFTTAMAVLANAGEA 368
            :..:.|:..:|:.|..||.||:||::....    ..:.:::|..|.|....:..|:       ||
Zfish   476 IGRIKKRHIYVISTIKRPVPLEHYLYTGNSTKTQKELFMLLDATGNFLTKGYYAAV-------EA 533

  Fly   369 GKGDQKGRHGGIKGT-NAGQTNIF---------KIVKMIMERNFAPVIIFSFSKKDCEIYAMQMA 423
             |.::..:|....|| |..|.|..         .::..:.:|...||:.|:||:..|:..|..:.
Zfish   534 -KKERTSKHAQSFGTKNVSQHNTTASQDRAVWQTLLNYLSQRQQTPVVAFTFSRTRCDENARSLT 597

  Fly   424 KLDFNTPDEKKLVDEVFNNAMDVLTEEDRRLPQVENVLPLLRRGIGIHHGGLLPILKETIEILFG 488
            .||..|..||..:......::..|...||:|||:..:..||:||||:||.|:||||||.||:||.
Zfish   598 SLDLTTSIEKSEIHSFLQKSLTRLRGGDRQLPQILLMRDLLKRGIGVHHSGILPILKEVIEMLFS 662

  Fly   489 EGLIKALFATETFAMGLNMPARTVLFTAPRKFDGKKFRWISSGEYIQMAGRAGRRGLDDKGIVIL 553
            .||:|.||||||||||:|||||||:|.:.||.||..||.:..||||||||||||||||..|.||:
Zfish   663 RGLVKVLFATETFAMGVNMPARTVVFDSIRKHDGTGFRNLLPGEYIQMAGRAGRRGLDATGTVII 727

  Fly   554 MIDEKVSPAVG--RDIVQGKADPINSAFHLTYNMVLNLLRVEEINPEYMLERSFYQFQNQAALPG 616
            :....|.. :|  ..::.||...::|.|.|||.|:|||||||.:....|::|||  .:|......
Zfish   728 LCKAGVHD-MGELHSMMLGKPTVLHSQFRLTYTMILNLLRVEALRVTDMMKRSF--SENHRDTQA 789

  Fly   617 LHDQVEQKTLELNKLTIKDEH----NIASYHHIRSQLDQHGKQFRQWITKPQYLLPFLQPGRLVK 677
            ...::.:....|:.|...|..    ::.||:|..::|....:..:|.:.:....|..|..||:|.
Zfish   790 HEKRISELRNTLSSLPPLDTEGQLSDLLSYYHTITELHITTQSLQQAVLESVNGLKALSVGRVVI 854

  Fly   678 VAAGSQEYDWGIVLNFKKQDQSRKNPLKAEPSVTIDVLLHV----SEAAAKTGDTEPCKPNERGC 738
            |.........|::|.......:|          |...|:..    .|||:.....:...|.....
Zfish   855 VNNSQHHNSLGVILQVSSDAVNR----------TFTALIICEKGNEEAASDEQSNKVALPIYSKT 909

  Fly   739 MEVV--PVAHTL----ITQISSIRVYFPNDLRSADNRRAVLKTIQE---------AKKRFPLGPP 788
            :.:.  |.:||:    :..||:|..             ..||.|.|         .:.||.|.||
Zfish   910 LFIPEGPCSHTVQKLKLQDISAITT-------------KALKVIPERIIDNYNKRLQPRFRLDPP 961

  Fly   789 -----------------------VLNPIDDMNIKDREFRDIVNTISQFEKRLEE-----HPLHKS 825
                                   ||:|::|:::|.   .|:|..:.: ::.|::     |.:| |
Zfish   962 GQAISTATQELLRLAEANMGGMTVLDPVNDLHLKG---VDVVEGVMR-QRVLQDSLKDFHCIH-S 1021

  Fly   826 PELERIHRRYQDKVTLQKQLQDLKAELKAARSLLQMDELKHRKRVLRRMGYCKPGDVIEFKGRVA 890
            |.......|.|:::::|::|..| ..|.:.:||..:.|...|.:||..:.|......::.|||||
Zfish  1022 PTFSEQFTRVQERMSVQEELDKL-LFLVSDQSLTLLPEYHQRIKVLEALQYVDSSGAVQLKGRVA 1085

  Fly   891 CELSSADELLMTEMIFNGVFNDLTAPQAVALLSCFVCDEKSSESVKSATELSGPLRSMQDLARRI 955
            |::|| .|||:||::|....:.|...::.|||||.|..:.:.........|...:..:..:|:||
Zfish  1086 CQISS-HELLLTELLFENTLSPLAPEESAALLSCLVFTQNTQIEPHITNTLQEGINQVLAVAQRI 1149

  Fly   956 AKVSTECKLDLDADTYVDKFKPFLMDVVLAWCKGSSFLAVCKMTDIFEGSIIRCMRRLEELLRQM 1020
            ..:..:|.:...|:.:|.:||..|.:||..|.:|..|..:.::||:.||:|:||::||:|:|:::
Zfish  1150 GDLQRDCGIAQTAEDFVAQFKFGLTEVVYCWARGMPFAEIAQLTDVQEGTIVRCIQRLDEVLKEV 1214

  Fly  1021 CQASKTIGNTDLENKFSEGIRLLKRDIVFAASLY 1054
            .||::.:|::.|.:|.......::|||||.||||
Zfish  1215 RQAARIVGDSVLGSKMERASLAIRRDIVFTASLY 1248

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mtr4	NP_524929.1	Dob10	145..1048	CDD:443638	353/969 (36%)
skic2	XP_073787022.1	None