DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mtr4 and mtrex

DIOPT Version :9

Sequence 1:	NP_524929.1	Gene:	Mtr4 / 48782	FlyBaseID:	FBgn0001986	Length:	1055	Species:	Drosophila melanogaster
Sequence 2:	NP_999933.1	Gene:	mtrex / 406795	ZFINID:	ZDB-GENE-040426-2854	Length:	1034	Species:	Danio rerio

Alignment Length:	1067	Identity:	661/1067 - (61%)
Similarity:	814/1067 - (76%)	Gaps:	54/1067 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EELFDCFDEVTPSVPPPALNQEEKPSGSSASKKGNKRQADGTTASKEATSSKGAEGDDKGDVTEE 68
            ::||..|||........|..:....:|.:..|.| |.|.|..:..|.       :.||.|
Zfish     7 DDLFSVFDEEQAGSSKKAAPKSAANAGKTPDKAG-KPQGDSASLRKR-------DADDDG----- 58

  Fly    69 PTKRL---KQEASTVAVDDDNNADDEPTRTLDIDDSATLEALRTRIVTHLLDAPKSCTHEVAAHP 130
            |.:.|   :|:..||:.::.|                 |..|..::.:..::..:.|||||....
Zfish    59 PDEMLLGKRQKLETVSAEEIN-----------------LSELMPKVKSEQVETVEGCTHEVVLPA 106

  Fly   131 DQEYIPLKPFSGVPAKEYPFVLDPFQRQAILCIDNSQSVLVSAHTSAGKTVVAEYAIAKSLAAKQ 195
            ::||.||||..|..||||||:||||||:|||||||:|||||||||||||||.||||||.:|..||
Zfish   107 NEEYTPLKPRVGKAAKEYPFILDPFQREAILCIDNNQSVLVSAHTSAGKTVCAEYAIALALREKQ 171

  Fly   196 RVIYTTPIKALSNQKFREFTDEFKDVGLVTGDVTINPSASCLIMTTEILRNMLYRGSEIMREVGW 260
            |||:|:|||||||||:||..:||:||||:||||||||:||||:|||||||:|||||||:||||.|
Zfish   172 RVIFTSPIKALSNQKYREMYEEFQDVGLMTGDVTINPTASCLVMTTEILRSMLYRGSEVMREVAW 236

  Fly   261 VVFDEIHYMRDKERGVVWEETLILLPDNVRYVFLSATIPNARQFAEWVCHLHKQPCHVVYTDYRP 325
            |:|||||||||.|||||||||:|||||||.:||||||:|||||||||:|||||||||||||||||
Zfish   237 VIFDEIHYMRDSERGVVWEETIILLPDNVHHVFLSATVPNARQFAEWICHLHKQPCHVVYTDYRP 301

  Fly   326 TPLQHYIFPAGGDGIHLIVDEKGQFKEDNFTTAMAVLANAGEAG-----KGDQKGRHGGIKGTNA 385
            ||||||||||||||:||:|||.|:|:||||.|||.||.:||:.|     |.|.|||.||.|
Zfish   302 TPLQHYIFPAGGDGLHLVVDENGEFREDNFNTAMQVLRDAGDTGGNTGAKWDPKGRKGGTK---- 362

  Fly   386 GQTNIFKIVKMIMERNFAPVIIFSFSKKDCEIYAMQMAKLDFNTPDEKKLVDEVFNNAMDVLTEE 450
            |.:|:||||||||||||.||||||||||:||.||:|::||||||.:|||||:||||||.|.|::|
Zfish   363 GPSNVFKIVKMIMERNFQPVIIFSFSKKECEAYALQVSKLDFNTDEEKKLVEEVFNNATDCLSDE 427

  Fly   451 DRRLPQVENVLPLLRRGIGIHHGGLLPILKETIEILFGEGLIKALFATETFAMGLNMPARTVLFT 515
            |::|||||:|||||:||||||||||||||||||||||.|||:||||||||||||:||||||||||
Zfish   428 DKKLPQVEHVLPLLKRGIGIHHGGLLPILKETIEILFSEGLLKALFATETFAMGINMPARTVLFT 492

  Fly   516 APRKFDGKKFRWISSGEYIQMAGRAGRRGLDDKGIVILMIDEKVSPAVGRDIVQGKADPINSAFH 580
            :.||||||.||||||||||||:|||||||:|::||||.|:|||:|||||:.:::|.|||:|||||
Zfish   493 SARKFDGKDFRWISSGEYIQMSGRAGRRGMDERGIVIFMVDEKMSPAVGKQLLKGSADPLNSAFH 557

  Fly   581 LTYNMVLNLLRVEEINPEYMLERSFYQFQNQAALPGLHDQVEQKTLELNKLTIKDEHNIASYHHI 645
            ||||||||||||||||||||||:||||||:..|:||:.|::::...|.|.:.|..|.::.:|:.|
Zfish   558 LTYNMVLNLLRVEEINPEYMLEKSFYQFQHYRAVPGVVDRMKKLEEEYNAIRIPKEESVVTYYKI 622

  Fly   646 RSQLDQHGKQFRQWITKPQYLLPFLQPGRLVKVAAGSQEYDWGIVLNFKKQDQSRKNPLKA---- 706
            |.||.:.||:..::|.||:|.||||||||||||.....::.||:|:||:|     |:.:||
Zfish   623 RQQLAKLGKEIEEFIHKPRYCLPFLQPGRLVKVKKEDLDFGWGVVVNFQK-----KSNVKAGGDL 682

  Fly   707 EPSVTIDVLLHVSEAAAKTGDTE---PCKPNERGCMEVVPVAHTLITQISSIRVYFPNDLRSADN 768
            :|...::||:|.|:.:.|...||   |..|.|:|.|:||||...|||.|||:|:|.|.|||..||
Zfish   683 DPLFVVEVLVHCSKDSVKNAATESARPAGPAEKGEMQVVPVILHLITSISSVRLYIPKDLRPYDN 747

  Fly   769 RRAVLKTIQEAKKRFPLGPPVLNPIDDMNIKDREFRDIVNTISQFEKRLEEHPLHKSPELERIHR 833
            |:::||:|||.:||||.|.|:|:|||||.|||...:.::..:..||.|:..||||..|.||.:::
Zfish   748 RQSMLKSIQEVQKRFPDGIPLLDPIDDMGIKDPALKKVIQKVEAFEHRMYTHPLHSDPNLEAVYK 812

  Fly   834 RYQDKVTLQKQLQDLKAELKAARSLLQMDELKHRKRVLRRMGYCKPGDVIEFKGRVACELSSADE 898
            ..:.|..:...::..|.|||.||::|||||||.|||||||:|:....||||.|||||||.||.||
Zfish   813 LCEKKALIAGDIKAAKRELKKARTVLQMDELKCRKRVLRRLGFATSSDVIEMKGRVACETSSGDE 877

  Fly   899 LLMTEMIFNGVFNDLTAPQAVALLSCFVCDEKSSESVKSATELSGPLRSMQDLARRIAKVSTECK 963
            ||:|||:|||:||||||.||.|||||||..|.::|..|...:|.||||.||:.|:||||||.|.|
Zfish   878 LLLTEMMFNGLFNDLTAEQATALLSCFVFQENANEMPKLTEQLGGPLRQMQECAKRIAKVSAEAK 942

  Fly   964 LDLDADTYVDKFKPFLMDVVLAWCKGSSFLAVCKMTDIFEGSIIRCMRRLEELLRQMCQASKTIG 1028
            |::|.|:|:::|:|.|||||..|..||||..:|||||:||||||||||||||||||||||:|.||
Zfish   943 LEVDEDSYLNQFRPHLMDVVYTWANGSSFSQICKMTDVFEGSIIRCMRRLEELLRQMCQAAKAIG 1007

  Fly  1029 NTDLENKFSEGIRLLKRDIVFAASLYL 1055
            ||:|||||:.||..:||||||||||||
Zfish  1008 NTELENKFATGITKIKRDIVFAASLYL 1034

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mtr4	NP_524929.1	Dob10	91..1055	CDD:226947	637/975 (65%)
		DEAD	154..299	CDD:278688	119/144 (83%)
		HELICc	390..554	CDD:238034	135/163 (83%)
		rRNA_proc-arch	600..853	CDD:289976	114/259 (44%)
		DSHCT	881..1048	CDD:285374	115/166 (69%)
mtrex	NP_999933.1	Dob10	15..1034	CDD:226947	655/1057 (62%)
		DEAD	130..275	CDD:278688	119/144 (83%)
		HELICc	433..521	CDD:197757	78/87 (90%)
		rRNA_proc-arch	577..832	CDD:289976	114/259 (44%)
		DSHCT	860..1027	CDD:285374	115/166 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594833
Domainoid	1	1.000	251	1.000	Domainoid score	I2062
eggNOG	1	0.900	-	-		E1_COG4581
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6257
Inparanoid	1	1.050	1305	1.000	Inparanoid score	I150
OMA	1	1.010	-	-		QHG53687
OrthoDB	1	1.010	-	-		D176060at2759
OrthoFinder	1	1.000	-	-		FOG0003580
OrthoInspector	1	1.000	-	-		oto41692
orthoMCL	1	0.900	-	-		OOG6_100340
Panther	1	1.100	-	-	LDO	PTHR12131
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R764
SonicParanoid	1	1.000	-	-		X2451
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800