Protein Alignment Mtr4 and Ddx60

DIOPT Version :10

• Sequence 1: NP_524929.1
• Gene: Mtr4 / 48782
• FlyBaseID: FBgn0001986
• Length: 1055
• Species: Drosophila melanogaster
• Sequence 2: NP_001280712.1
• Gene: Ddx60 / 234311
• MGIID: 2384570
• Length: 1710
• Species: Mus musculus
• Alignment Length: 1115
• Identity: 210/1115 - (18%)
• Similarity: 380/1115 - (34%)
• Gaps: 402/1115 - (36%)

  Fly    71 KRLKQEASTVAVDDDNNADDEPTRTLDI-------------DDSATLEALRTRIVTHLLDAPKSC 122
            :|:..:|...|..:...|:.|.|:.|.|             ..|..|:....:::...|.....|
Mouse   639 ERVGLQACLKAWKEHCQAEGETTKDLSIAVNMMKRIHSLLDKHSELLQEADQKLIARCLKYLGFC 703

  Fly   123 THEVAAHPDQEY---IPLKPFS----GV-PAK---EY------------------PFVLDPFQRQ 158
            ...|:.:|.|:.   |.:|..:    |: ||:   :|                  .|:.|.:||:
Mouse   704 ELAVSLYPTQDASDGIKMKKKNKYSVGIGPARFQLQYMGHYLIREERKDPDPRVQDFIPDTWQRE 768

  Fly   159 AILCIDNSQSVLVSAHTSAGKTVVAEYAIAKSLAAKQR--VIYTTPIKALSNQKFREFTDEFKDV 221
            .:..:||.:|.::.|.||:|||..:.|.:.|.|.....  |:|..|.|||.||.  ..|.|::..
Mouse   769 LLDVVDNYESAVIVAPTSSGKTYASYYCMEKVLKESDEGVVVYVAPTKALVNQV--AATVEYRYA 831

  Fly   222 ----------GLVTGDVTINPSASCLIMTT-----EILRNMLYRGSEIMREVGWVVFDEIHYMRD 271
                      |:.|.|.. :.:.:|.::.|     |||....:|.:.:.| :.:|:|||:|.:..
Mouse   832 KNMPAGESLCGVFTRDYR-HDALNCQVLITVPACFEILLLAPHRQNWVKR-IRYVIFDEVHCLGG 894

  Fly   272 KERGVVWEETLILLPDNVRYVFLSATIPNARQFAEW----------------------------- 307
            :....:||..|:::  ...::.|||||.|.:...||
Mouse   895 EIGAEIWEHLLVMI--RCPFLALSATISNPQHLTEWLQSVKRYWKQVDSTMEERTVSKRTGTSRG 957

  Fly   308 --------------------------------------VCHLHKQPCHVVYTDYRPTPLQHYIFP 334
                                                  ||..|..||..:..|:    ::.|.||
Mouse   958 SYYKDQAQARQSYKVRLVLYGERYNDLEKYLCSVRQGDVCFDHFHPCAALTIDH----IEKYGFP 1018

  Fly   335 AGGDGIHLIVDEKGQFKE-----------------DNFTT-AMAVLANAGEAGKGDQKGRH---G 378
            :   .:.|...|..|..:                 :|||. ...::....:|.|.::..:.   .
Mouse  1019 S---DLALSPRESIQLYDTMCQVWKSWPQAQSLCPENFTQFKNKIVIKKLDARKYEESLKEEFTN 1080

  Fly   379 GIKGTNAGQTN-IFK-------------------IVKMIMERNFAPVIIFSF------------- 410
            .:|..|..:.. :.|                   :|:.:.:....|.:.|.|
Mouse  1081 WVKNGNEEEARMVLKKLSPDYHEHSGRMLDFFPCLVEKLRKMEKLPALFFLFKLNIVEECAENAF 1145

  Fly   411 --------------SKKDCEIYAMQMAKLDFNTPDEKKLVDEVFNNAMDVLTE------------ 449
                          :.|:....|.::.|:. .:.:::|.|||....:...|.|
Mouse  1146 EFLEKKQEEKRPPKADKEARTTANKLRKVK-KSLEKQKTVDEKGQKSSRRLDESVMHETEHNYLL 1209

  Fly   450 ---------------------EDRRLPQV----------ENVLPLLRRGIGIHHGGLLPILKETI 483
                                 :|:.|.:|          |.:..|..||||.||..:....|:.:
Mouse  1210 QTLEKNLEIPKDCTYANQKAIDDQLLQRVFHRVRFERKGETLKRLAERGIGYHHSSMSAKEKQLV 1274

  Fly   484 EILFGEGLIKALFATETFAMGLNMPARTVLFTAPRKFDGKKFRWISSGEYIQMAGRAGRRGLDDK 548
            ||||.:|.|:.:.||.|.|:|:|||.::|:|       .:...::.:..|.||:|||||||.|..
Mouse  1275 EILFRKGFIRVVTATGTLALGINMPCKSVVF-------AQNSVYLDALNYRQMSGRAGRRGQDLL 1332

  Fly   549 GIVILMIDEKVSPAVGRDIVQGKADPINSAFHLTYNMVLNLL----RVEEINPE-----YMLERS 604
            |.|...  :...|.:|: :::.|...:...|.|:.:::|.|:    :.:::...     .:|:.|
Mouse  1333 GDVYFF--DIPLPKIGK-LIKSKVPELRGQFPLSISLILRLMLLASKADDLEDGKAKALSVLKHS 1394

  Fly   605 FYQFQNQAALPGLHDQVEQKTLELNKLTIKDEHNIASYHHIRSQLDQHGKQ--FRQWITKPQYLL 667
            ...|:...|:    |.::...|...:..:|:.|           :||.|..  |...::.    |
Mouse  1395 LLSFKQPRAI----DMLKLYFLYSLQFLVKEGH-----------IDQEGNPTGFAGLVSH----L 1440

  Fly   668 PFLQPGRLVKVAAGSQEYDWGIVLNFKKQDQSRKNPLKAEPSVTIDVLLHVSEAAAKTGDTEPCK 732
            .:.:|..||.|                              |..:..|.|           :.|:
Mouse  1441 HYHEPSNLVFV------------------------------SFLVKGLFH-----------KLCQ 1464

  Fly   733 PNERGCMEVVP------VAHTLITQISSI--RVYFPNDLRSADNRRAVLKTIQEAKKRFPLGPPV 789
            |...|     |      |...|:..::::  |.|.|......:::....|..
Mouse  1465 PTREG-----PKRFSEDVMEKLVLVLANLFGRRYIPAKFYEVNSKFYQSKVF------------- 1511

  Fly   790 LNPIDDMNIKDREFRDIVNTISQFEKRLEEHPLHKSPELERIHRRYQDKVTLQKQLQDLKAELKA 854
               :||:.      .|..:.:.::..::.|.              :...:.:..:|.|:|.|.:.
Mouse  1512 ---LDDLP------EDFSHALLEYNTQVTED--------------FASFLLMVSRLADMKQEYQL 1553

  Fly   855 ARSLLQM--DELKHRKRVLRRMGYCKPGDVIEFKGRVA-----CELSSADELLMTEMIFNGV--- 909
            :.|.::.  .|.:....|...|. ||       :||||     |...:.|..|::..:.|.|
Mouse  1554 SLSKIEFTGKECEDSPLVSHLMN-CK-------EGRVAVSPFVCLSGNFDVDLLSPGVPNHVILH 1610

  Fly   910 ---FNDLTAP 916
               .|...||
Mouse  1611 TLGINHTQAP 1620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mtr4	NP_524929.1	Dob10	145..1048	CDD:443638	191/1020 (19%)
Ddx60	NP_001280712.1	DEXHc_DDX60	761..938	CDD:350783	51/182 (28%)
		BRR2	766..1440	CDD:440817	143/716 (20%)