Protein Alignment Mtr4 and skih-2

DIOPT Version :10

• Sequence 1: NP_524929.1
• Gene: Mtr4 / 48782
• FlyBaseID: FBgn0001986
• Length: 1055
• Species: Drosophila melanogaster
• Sequence 2: NP_502084.2
• Gene: skih-2 / 178017
• WormBaseID: WBGene00008502
• Length: 1266
• Species: Caenorhabditis elegans
• Alignment Length: 1173
• Identity: 379/1173 - (32%)
• Similarity: 575/1173 - (49%)
• Gaps: 187/1173 - (15%)

  Fly    11 DEVTPSVPPPALNQEEKPSGSSASKKGNKRQADGTTASKEATSSKGAEGDDKGDVTE-------- 67
            |:.|.....|.:.|...|:.||..|..            |...|...|..|..|:.:
 Worm   149 DDATLLNTIPTIGQIVLPNHSSVKKPA------------ETPKSINIEEMDMFDLLDMVTSNEYI 201

  Fly    68 -----EPTKRLKQEASTVAVDDDNNADDEPTRTLDIDDSATLEALRTRIVTHLLDAPKSCTHE-- 125
                 .|.|:.:...|....:||....:.....::|    .:....|..|..:..|....|.|
 Worm   202 IHTVAAPVKKSESIESEETPEDDKKVSENEIDEIEI----PIIPGNTEKVIEIFGAATEPTKEKF 262

  Fly   126 -------VAAHPDQEYIPLKPFSGVPAKEYPFVLDPFQRQAILCIDNSQSVLVSAHTSAGKTVVA 183
                   ::|..:.||..|.|   ..|::|||.|||||:.::||::..:|:.|:|||||||||||
 Worm   263 EFAQRLVLSADEEDEYKRLVP---TMARKYPFSLDPFQQSSVLCMERGESLFVAAHTSAGKTVVA 324

  Fly   184 EYAIAKSLAAKQRVIYTTPIKALSNQKFREFTDEFKDVGLVTGDVTINPSASCLIMTTEILRNML 248
            |||||...|.|.|.:||:|||||||||||:|...|.||||||||:.::|.|:||||||||||:||
 Worm   325 EYAIALCQAHKTRAVYTSPIKALSNQKFRDFKQIFGDVGLVTGDIQLHPEAACLIMTTEILRSML 389

  Fly   249 YRGSEIMREVGWVVFDEIHYMRDKERGVVWEETLILLPDNVRYVFLSATIPNARQFAEWVCHLHK 313
            |.|||::|::.||||||:||:.::|||.||||.||:||.:|:.|.||||:||..:||:||..:..
 Worm   390 YNGSEVIRDLEWVVFDEVHYINNEERGHVWEEVLIMLPAHVKIVMLSATVPNCVEFADWVGRIKN 454

  Fly   314 QPCHVVYTDYRPTPLQHYIFPAGGDG-----IHLIVDEKGQFKEDNFTTAMAVLAN-------AG 366
            :..:|:.||.||.||:|::: .|.||     :..|:|..|||....:..|....|.       .|
 Worm   455 RKINVISTDRRPVPLEHFLY-TGQDGKTQKDLFKIIDRSGQFILKGYNDAKDSKAKIYEKEKAGG 518

  Fly   367 EAGKGDQKGRHGGIKGTNAGQT-------NIF-KIVKMIMERNFAPVIIFSFSKKDCEIYAMQMA 423
            ..|:|.|:|...|..|...|:.       ||: .::..:...:..|:::|.||:|.|:..|..:|
 Worm   519 AGGRGTQRGGGRGGGGNGGGRNWPGKNDKNIYLNLINYMKCSDQLPMVVFVFSRKRCDENAQMLA 583

  Fly   424 KLDFNTPDEKKLVDEVFNNAMDVLTEEDRRLPQVENVLPLLRRGIGIHHGGLLPILKETIEILFG 488
            .::..|..||:.|...|:..:..|...|:.||||..:..|..||..:||.|:||||||.:|:||.
 Worm   584 SMNLTTEVEKQHVRLFFSQCVQRLKGSDKELPQVLTMRDLCLRGFAVHHSGILPILKEVVELLFQ 648

  Fly   489 EGLIKALFATETFAMGLNMPARTVLFTAPRKFDGKKFRWISSGEYIQMAGRAGRRGLDDKGIVIL 553
            :|.:|.||||||||||:|||||.|:|.:..|.||.:.|.::.|||.||||||||||||..|.||:
 Worm   649 KGYVKILFATETFAMGVNMPARCVVFDSIMKHDGTERRMLNPGEYTQMAGRAGRRGLDLTGTVII 713

  Fly   554 MIDEKV--SPAVGRDIVQGKADPINSAFHLTYNMVLNLLRVEEINPEYMLERSFYQFQNQAALPG 616
            :..:..  .|.|.::::.|:|..:.|.|.:||:|:|||||||::..|.||:||:.:..:
 Worm   714 ICKDSTVPQPDVLKNLISGQALRLESKFRVTYSMILNLLRVEQLKIEDMLQRSYVESDS------ 772

  Fly   617 LHDQVE-QKTLELNKLTIKDEHNI-ASYHHIRSQLDQHGKQFRQWITKPQYLLP----------F 669
            |.:..| :|:|...|..|:....| .|.....|||..:......::.|.:::.|          .
 Worm   773 LRESKEKRKSLVDTKNAIQTMSTIECSTCSPNSQLRDYHDALAVFLRKSEHIWPKLNDENVINKL 837

  Fly   670 LQPGRLVKVAAGSQEYDWGIVLNFKK---------------QDQSRKNPL--------KAEPSVT 711
            |..||.:.|.:..|:.....||..|:               .:.:.||..        |:|.|..
 Worm   838 LCSGRFLIVNSAQQQLQNECVLLIKELNNKTLQILVASADADETTNKNAAAIGFSKLPKSELSWL 902

  Fly   712 IDVLLHVSEAAAKTGDTEPCKPNERG-----------------CMEVVPVAHTL----ITQISSI 755
            .:....:|.:...|.....|..|.|.                 |.:.|.....|    :|||...
 Worm   903 TEENSLLSTSKFGTRGAAHCSTNIRSFRLCEIPLSGIVAVMKKCAKGVQSGEILQEYNMTQIPRF 967

  Fly   756 RVYFPNDLRSADNRRAVLKTIQEAKKRFPLGPPVLNPIDDMNIK---------DREF-RDIVNTI 810
            |     |...::|.:.:|:.|..|......|     .|:....|         |..| .|::..:
 Worm   968 R-----DRELSENVKKLLQQITTAVPGLKSG-----EIETYTWKELGSFCQNLDTSFDTDLLEKL 1022

  Fly   811 SQFEKRLEEHPLHKSPELERIHRRYQDKVTLQKQLQDLKAELKAARSLLQMDELKHRKRVLRRMG 875
            .......:..|.......:......:|::.::::::.|:.|| ::.:||..:|..:|.:||..:.
 Worm  1023 EYNLNLPQSFPARHCTRFDEHFSVLRDRIRIERKIESLEYEL-SSDALLLSEEYHNRLKVLEALN 1086

  Fly   876 YCKPGDVIEFKGRVACELSSADELLMTEMIFNGVFNDLTAPQAVALLSCFVCDEKS--------- 931
            :.:. .::..|||:.||:.. .|||:||:|.:..|:..:..:..||||...|...|
 Worm  1087 FVEQ-KMVSLKGRIGCEIHH-QELLITELILDYKFHQRSPAELAALLSTLTCQYNSGREMQFGGD 1149

  Fly   932 ------SESVKSATELSGPLRSMQDLARR----IAKVSTECKLDLDADTYVDKFKPFLMDVVLAW 986
                  ||||||.      |..::.:|.:    |:.:..|.:.|             ||:||..|
 Worm  1150 TVFGEISESVKSV------LTRLESVASKHKSQISDLGCEIRFD-------------LMEVVYEW 1195

  Fly   987 CKGSSFLAVCKMTDIFEGSIIRCMRRLEELLRQMCQASKTIGNTDLENKFSEGIRLLKRDIVFAA 1051
            ..|:.|..:.:|||..||.|::|::||:|:.:.:..|.:.:|:..|..|..|....::|||||||
 Worm  1196 ANGTPFYQIMEMTDCQEGLIVKCIQRLDEVCKDVRNAGRIVGDPALVEKMEEVSASIRRDIVFAA 1260

  Fly  1052 SLY 1054
            |||
 Worm  1261 SLY 1263

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mtr4	NP_524929.1	Dob10	145..1048	CDD:443638	342/1009 (34%)
skih-2	NP_502084.2	Ski2_N	<66..158	CDD:465562	2/8 (25%)
		Dob10	289..>766	CDD:443638	226/477 (47%)
		DSHCT	1093..1257	CDD:462374	53/183 (29%)