Protein Alignment Mtr4 and skic2

DIOPT Version :10

• Sequence 1: NP_524929.1
• Gene: Mtr4 / 48782
• FlyBaseID: FBgn0001986
• Length: 1055
• Species: Drosophila melanogaster
• Sequence 2: XP_017952200.1
• Gene: skic2 / 100038207
• XenbaseID: XB-GENE-486233
• Length: 1253
• Species: Xenopus tropicalis
• Alignment Length: 1148
• Identity: 398/1148 - (34%)
• Similarity: 594/1148 - (51%)
• Gaps: 169/1148 - (14%)

  Fly     4 EELFDCFDEVTPSVPPPALNQEEKPSGSSASKKG-NKRQAD-----GT-TASKEATSSKGAEGDD 61
            ||:...|:....:|||             ..|.| |.:|:|     || |.|....:.:.....|
 Frog   176 EEVALDFNNDLLAVPP-------------GWKYGMNFKQSDILHPAGTLTLSSLLGTLEDFTFGD 227

  Fly    62 KGDVTEEPTKRLKQEASTVAVDDDNNADDEPTRTLDIDDSATLEALRTRIVTHLLDAP------- 119
            ..|..|...||             :.|..|.|:|..:..|.:||.|...:......:|
 Frog   228 SSDDEEAGEKR-------------SGAGTERTKTEGLQRSNSLEELGLEVTEWTKSSPVLAPVLP 279

  Fly   120 -KSCTHEVAAHPDQEYIPLKPF-SGVP--AKEYPFVLDPFQRQAILCIDNSQSVLVSAHTSAGKT 180
             ....||..|.|.....|:..| ..:|  |.::||.|||||::||.|::...||.::||||||||
 Frog   280 EAEVPHEQWAVPLDSNSPVANFYKQIPDLAFKHPFELDPFQKKAIQCLEAGSSVFIAAHTSAGKT 344

  Fly   181 VVAEYAIAKSLAAKQRVIYTTPIKALSNQKFREFTDEFKDVGLVTGDVTINPSASCLIMTTEILR 245
            ||||||||.||....|.|||:|||||||||||:|...|.||||:||||.:...||||||||||||
 Frog   345 VVAEYAIALSLKHMTRAIYTSPIKALSNQKFRDFKITFGDVGLITGDVQLYTGASCLIMTTEILR 409

  Fly   246 NMLYRGSEIMREVGWVVFDEIHYMRDKERGVVWEETLILLPDNVRYVFLSATIPNARQFAEWVCH 310
            :|||.||:::|::.||:|||:||:.|.||||||||.||:|||:|..:.||||:||..:||:|:..
 Frog   410 SMLYNGSDVIRDLEWVIFDEVHYINDAERGVVWEEVLIMLPDHVNIILLSATVPNTVEFADWIGR 474

  Fly   311 LHKQPCHVVYTDYRPTPLQHYIFPAGG----DGIHLIVDEKGQFKEDNFTTAMAVLANAGEAGKG 371
            :.|:..:|:.|..||.||:||::....    :...|::|..|.|:...:..  ||.|....:.|.
 Frog   475 IKKKKIYVISTTRRPVPLEHYLYTGNSQKTQNQFFLLLDALGGFQTKGYYA--AVEAKKERSSKY 537

  Fly   372 DQ----KGRHGGIKGTNAGQTNIFKIVKMIMERNFAPVIIFSFSKKDCEIYAMQMAKLDFNTPDE 432
            .|    |..||...|.:.|  ....:|:.:..|:..||::|:||:..||..|..::.:|..:..|
 Frog   538 SQTFGAKHPHGVGPGHDKG--TWLSLVQSLKIRDALPVVVFTFSRTRCEQNATALSTVDLCSTAE 600

  Fly   433 KKLVDEVFNNAMDVLTEEDRRLPQVENVLPLLRRGIGIHHGGLLPILKETIEILFGEGLIKALFA 497
            |..|...:...:..|...||:||||.::|.||:|||||||.|:||||||.:|:||..||:|.|||
 Frog   601 KSEVQTYYTKCLSRLRGADRQLPQVLHMLDLLKRGIGIHHSGILPILKEVVEMLFSRGLVKILFA 665

  Fly   498 TETFAMGLNMPARTVLFTAPRKFDGKKFRWISSGEYIQMAGRAGRRGLDDKGIVILMIDEKVSPA 562
            |||||||:|||||||:|.:.||.||..||.::.||||||||||||||||:.|:||::....| |.
 Frog   666 TETFAMGVNMPARTVVFDSIRKHDGSNFRDLTPGEYIQMAGRAGRRGLDNTGMVIILCKADV-PE 729

  Fly   563 VG--RDIVQGKADPINSAFHLTYNMVLNLLRVEEINPEYMLERSFYQFQNQAALPGLHDQVEQKT 625
            :.  ..::.||...:.|.|.|||:|:|||||||.:..|.|::|||.:.:.|........:::..|
 Frog   730 MSDLHKMMLGKPTQLQSQFRLTYSMILNLLRVEALRVEDMMKRSFAESRTQRDSKAHEQRIKLLT 794

  Fly   626 LELNKL-TIKDEHNIASYH----------HIRSQLDQH-------------------GKQFRQWI 660
            .:|..: .|:...::|..|          :.|..:.:.                   ..::..|:
 Frog   795 QQLADVGDIECSGDLADLHDYFVTVQELIYTRETVQKRVVESINGMKCLSVGRIIIINTEYHSWV 859

  Fly   661 TKPQYLLPFLQPGRLVKVAAGSQEYDWGIVLNFKKQ-------DQSRKNPLKAEPSVTIDVLLHV 718
                       ||.:::|::.:....:..::.::|:       .::|:..:|..| |..|:|:
 Frog   860 -----------PGVILQVSSDAANRIYTTLVLYEKRREIGVLHQETREKEVKKAP-VPEDLLM-- 910

  Fly   719 SEAAAKTGDTE-PCKPNERGCMEVVPVAHTLITQISSIRVYFPNDLR-SADNRRAVLKTIQEAK- 780
                .|....| ||.            ...|..:.|.|.:.....|| .||.   :|..|.:::
 Frog   911 ----GKVFRPEGPCD------------YRLLKLRSSDINIVTGKTLRIHADK---ILDDIAKSQM 956

  Fly   781 ---KRFPLGPPV--------------------LNPIDDMNIKDREFRDIVNTISQFEKRLEEHPL 822
               :..|.||.:                    |.|::|:.:|:.|..:.|:...:.|:.|:....
 Frog   957 PRYRNDPPGPALSSVTQELARLADLPSGSLSSLCPVNDLQLKELELVEAVSRGKRLEEALQSFSC 1021

  Fly   823 HKSPELERIHRRYQDKVTLQKQLQDLKAELKAAR------SLLQMDELKHRKRVLRRMGYCKPGD 881
            :.||       |:..:..|.:|...:..||:..|      ||..:.|.:.|..|||.:.|...|.
 Frog  1022 YNSP-------RFNTQYILLEQRSQVLNELERLRFLTSDQSLSLLPEYQQRVNVLRTLQYIDDGG 1079

  Fly   882 VIEFKGRVACELSSADELLMTEMIFNGVFNDLTAPQAVALLSCFVCDEKSSESVKSATELSGPLR 946
            .::.|||||||:|| .|||:||::.:|..:.|...:..|||||.|...|:....:....|...::
 Frog  1080 AVQLKGRVACEVSS-HELLVTELVLDGALSPLAPEEIAALLSCLVFQHKTQCEPRLTDTLKQGVK 1143

  Fly   947 SMQDLARRIAKVSTECKLDLDADTYVDKFKPFLMDVVLAWCKGSSFLAVCKMTDIFEGSIIRCMR 1011
            .:::||.|:|.:..||.|....:.:|.::|..|.:||..|.:|..|..:..:|||.||.|:||::
 Frog  1144 KVRELAERLALIQRECGLRESVEDFVAQYKFGLTEVVYEWARGMPFSEIMTLTDIQEGLIVRCVQ 1208

  Fly  1012 RLEELLRQMCQASKTIGNTDLENKFSEGIRLLKRDIVFAASLY 1054
            ||:|..|.:..|::.:|:..|..|.....:|:||||:||||||
 Frog  1209 RLDEACRDVRSAARLVGDATLCAKMDAASQLIKRDIIFAASLY 1251

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mtr4	NP_524929.1	Dob10	145..1048	CDD:443638	355/981 (36%)
skic2	XP_017952200.1	Ski2_N	78..203	CDD:465562	10/39 (26%)
		Dob10	312..1245	CDD:443638	354/978 (36%)