DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mtr4 and skiv2l

DIOPT Version :9

Sequence 1:	NP_524929.1	Gene:	Mtr4 / 48782	FlyBaseID:	FBgn0001986	Length:	1055	Species:	Drosophila melanogaster
Sequence 2:	XP_017952200.1	Gene:	skiv2l / 100038207	XenbaseID:	XB-GENE-486233	Length:	1253	Species:	Xenopus tropicalis

Alignment Length:	1148	Identity:	398/1148 - (34%)
Similarity:	594/1148 - (51%)	Gaps:	169/1148 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EELFDCFDEVTPSVPPPALNQEEKPSGSSASKKG-NKRQAD-----GT-TASKEATSSKGAEGDD 61
            ||:...|:....:|||             ..|.| |.:|:|     || |.|....:.:.....|
Frog   176 EEVALDFNNDLLAVPP-------------GWKYGMNFKQSDILHPAGTLTLSSLLGTLEDFTFGD 227

  Fly    62 KGDVTEEPTKRLKQEASTVAVDDDNNADDEPTRTLDIDDSATLEALRTRIVTHLLDAP------- 119
            ..|..|...||             :.|..|.|:|..:..|.:||.|...:......:|
Frog   228 SSDDEEAGEKR-------------SGAGTERTKTEGLQRSNSLEELGLEVTEWTKSSPVLAPVLP 279

  Fly   120 -KSCTHEVAAHPDQEYIPLKPF-SGVP--AKEYPFVLDPFQRQAILCIDNSQSVLVSAHTSAGKT 180
             ....||..|.|.....|:..| ..:|  |.::||.|||||::||.|::...||.::||||||||
Frog   280 EAEVPHEQWAVPLDSNSPVANFYKQIPDLAFKHPFELDPFQKKAIQCLEAGSSVFIAAHTSAGKT 344

  Fly   181 VVAEYAIAKSLAAKQRVIYTTPIKALSNQKFREFTDEFKDVGLVTGDVTINPSASCLIMTTEILR 245
            ||||||||.||....|.|||:|||||||||||:|...|.||||:||||.:...||||||||||||
Frog   345 VVAEYAIALSLKHMTRAIYTSPIKALSNQKFRDFKITFGDVGLITGDVQLYTGASCLIMTTEILR 409

  Fly   246 NMLYRGSEIMREVGWVVFDEIHYMRDKERGVVWEETLILLPDNVRYVFLSATIPNARQFAEWVCH 310
            :|||.||:::|::.||:|||:||:.|.||||||||.||:|||:|..:.||||:||..:||:|:..
Frog   410 SMLYNGSDVIRDLEWVIFDEVHYINDAERGVVWEEVLIMLPDHVNIILLSATVPNTVEFADWIGR 474

  Fly   311 LHKQPCHVVYTDYRPTPLQHYIFPAGG----DGIHLIVDEKGQFKEDNFTTAMAVLANAGEAGKG 371
            :.|:..:|:.|..||.||:||::....    :...|::|..|.|:...:..  ||.|....:.|.
Frog   475 IKKKKIYVISTTRRPVPLEHYLYTGNSQKTQNQFFLLLDALGGFQTKGYYA--AVEAKKERSSKY 537

  Fly   372 DQ----KGRHGGIKGTNAGQTNIFKIVKMIMERNFAPVIIFSFSKKDCEIYAMQMAKLDFNTPDE 432
            .|    |..||...|.:.|  ....:|:.:..|:..||::|:||:..||..|..::.:|..:..|
Frog   538 SQTFGAKHPHGVGPGHDKG--TWLSLVQSLKIRDALPVVVFTFSRTRCEQNATALSTVDLCSTAE 600

  Fly   433 KKLVDEVFNNAMDVLTEEDRRLPQVENVLPLLRRGIGIHHGGLLPILKETIEILFGEGLIKALFA 497
            |..|...:...:..|...||:||||.::|.||:|||||||.|:||||||.:|:||..||:|.|||
Frog   601 KSEVQTYYTKCLSRLRGADRQLPQVLHMLDLLKRGIGIHHSGILPILKEVVEMLFSRGLVKILFA 665

  Fly   498 TETFAMGLNMPARTVLFTAPRKFDGKKFRWISSGEYIQMAGRAGRRGLDDKGIVILMIDEKVSPA 562
            |||||||:|||||||:|.:.||.||..||.::.||||||||||||||||:.|:||::....| |.
Frog   666 TETFAMGVNMPARTVVFDSIRKHDGSNFRDLTPGEYIQMAGRAGRRGLDNTGMVIILCKADV-PE 729

  Fly   563 VG--RDIVQGKADPINSAFHLTYNMVLNLLRVEEINPEYMLERSFYQFQNQAALPGLHDQVEQKT 625
            :.  ..::.||...:.|.|.|||:|:|||||||.:..|.|::|||.:.:.|........:::..|
Frog   730 MSDLHKMMLGKPTQLQSQFRLTYSMILNLLRVEALRVEDMMKRSFAESRTQRDSKAHEQRIKLLT 794

  Fly   626 LELNKL-TIKDEHNIASYH----------HIRSQLDQH-------------------GKQFRQWI 660
            .:|..: .|:...::|..|          :.|..:.:.                   ..::..|:
Frog   795 QQLADVGDIECSGDLADLHDYFVTVQELIYTRETVQKRVVESINGMKCLSVGRIIIINTEYHSWV 859

  Fly   661 TKPQYLLPFLQPGRLVKVAAGSQEYDWGIVLNFKKQ-------DQSRKNPLKAEPSVTIDVLLHV 718
                       ||.:::|::.:....:..::.::|:       .::|:..:|..| |..|:|:
Frog   860 -----------PGVILQVSSDAANRIYTTLVLYEKRREIGVLHQETREKEVKKAP-VPEDLLM-- 910

  Fly   719 SEAAAKTGDTE-PCKPNERGCMEVVPVAHTLITQISSIRVYFPNDLR-SADNRRAVLKTIQEAK- 780
                .|....| ||.            ...|..:.|.|.:.....|| .||.   :|..|.:::
Frog   911 ----GKVFRPEGPCD------------YRLLKLRSSDINIVTGKTLRIHADK---ILDDIAKSQM 956

  Fly   781 ---KRFPLGPPV--------------------LNPIDDMNIKDREFRDIVNTISQFEKRLEEHPL 822
               :..|.||.:                    |.|::|:.:|:.|..:.|:...:.|:.|:....
Frog   957 PRYRNDPPGPALSSVTQELARLADLPSGSLSSLCPVNDLQLKELELVEAVSRGKRLEEALQSFSC 1021

  Fly   823 HKSPELERIHRRYQDKVTLQKQLQDLKAELKAAR------SLLQMDELKHRKRVLRRMGYCKPGD 881
            :.||       |:..:..|.:|...:..||:..|      ||..:.|.:.|..|||.:.|...|.
Frog  1022 YNSP-------RFNTQYILLEQRSQVLNELERLRFLTSDQSLSLLPEYQQRVNVLRTLQYIDDGG 1079

  Fly   882 VIEFKGRVACELSSADELLMTEMIFNGVFNDLTAPQAVALLSCFVCDEKSSESVKSATELSGPLR 946
            .::.|||||||:|| .|||:||::.:|..:.|...:..|||||.|...|:....:....|...::
Frog  1080 AVQLKGRVACEVSS-HELLVTELVLDGALSPLAPEEIAALLSCLVFQHKTQCEPRLTDTLKQGVK 1143

  Fly   947 SMQDLARRIAKVSTECKLDLDADTYVDKFKPFLMDVVLAWCKGSSFLAVCKMTDIFEGSIIRCMR 1011
            .:::||.|:|.:..||.|....:.:|.::|..|.:||..|.:|..|..:..:|||.||.|:||::
Frog  1144 KVRELAERLALIQRECGLRESVEDFVAQYKFGLTEVVYEWARGMPFSEIMTLTDIQEGLIVRCVQ 1208

  Fly  1012 RLEELLRQMCQASKTIGNTDLENKFSEGIRLLKRDIVFAASLY 1054
            ||:|..|.:..|::.:|:..|..|.....:|:||||:||||||
Frog  1209 RLDEACRDVRSAARLVGDATLCAKMDAASQLIKRDIIFAASLY 1251

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mtr4	NP_524929.1	Dob10	91..1055	CDD:226947	377/1054 (36%)
		DEAD	154..299	CDD:278688	95/144 (66%)
		HELICc	390..554	CDD:238034	87/163 (53%)
		rRNA_proc-arch	600..853	CDD:289976	52/315 (17%)
		DSHCT	881..1048	CDD:285374	59/166 (36%)
skiv2l	XP_017952200.1	Ski2_N	78..203	CDD:407762	10/39 (26%)
skiv2l	XP_017952200.1	Dob10	277..1251	CDD:226947	367/1019 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D176060at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920