DRSC/TRiP Functional Genomics Resources

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Protein Alignment NimC3 and Megf10

DIOPT Version :10

Sequence 1:NP_524928.2 Gene:NimC3 / 48772 FlyBaseID:FBgn0001967 Length:224 Species:Drosophila melanogaster
Sequence 2:NP_001001979.1 Gene:Megf10 / 70417 MGIID:2685177 Length:1147 Species:Mus musculus


Alignment Length:153 Identity:33/153 - (21%)
Similarity:51/153 - (33%) Gaps:54/153 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    59 HPIDLDSYVVYEERVRWDNIQVCCPGY---RTILFGFCEPVCQEACPAHSYCAEPDRCHCQRGYE 120
            |.|...:...:.|:..:.....||||:   |.:    |.|.|.:.| .|..|..|:.|.|:.|:.
Mouse    72 HRISYRTAYRHGEKTMYRRKSQCCPGFYESRDM----CVPHCADKC-VHGRCIAPNTCQCEPGWG 131

  Fly   121 PSH-------HHTTGH---------QLICRPV--------------CQGGCPE-------HSHCV 148
            .::       .|...|         :.:|.|:              |:..|.:       |..|.
Mouse   132 GTNCSSACDGDHWGPHCSSRCQCKNRALCNPITGACHCAAGYRGWRCEDRCEQGTYGNDCHQRCQ 196

  Fly   149 AHN---------ECECWPGFKDA 162
            ..|         ||.|.||:..|
Mouse   197 CQNGATCDHITGECRCSPGYTGA 219

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NimC3NP_524928.2 None
Megf10NP_001001979.1 Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern. /evidence=ECO:0000250|UniProtKB:Q96KG7 1..857 33/153 (22%)
EMI 31..100 CDD:462204 7/27 (26%)
EGF_Lam 281..318 CDD:214543
EGF_CA 542..587 CDD:473889
Necessary for formation of large intracellular vacuoles. /evidence=ECO:0000250|UniProtKB:Q96KG7 945..1147
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1093..1147
Blue background indicates that the domain is not in the aligned region.

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