Protein Alignment Hsp70Aa and LHS1

DIOPT Version :10

• Sequence 1: NP_731651.1
• Gene: Hsp70Aa / 48581
• FlyBaseID: FBgn0013275
• Length: 642
• Species: Drosophila melanogaster
• Sequence 2: NP_012850.1
• Gene: LHS1 / 853789
• SGDID: S000001556
• Length: 881
• Species: Saccharomyces cerevisiae
• Alignment Length: 676
• Identity: 159/676 - (23%)
• Similarity: 296/676 - (43%)
• Gaps: 113/676 - (16%)

  Fly     4 IGIDLG-TTYSCVGVYQHGKVEIIANDQGNRTTPSYVAF-----------TDSERLIGDPAKNQV 56
            :|:|.| .....:.|.....:|::...:..|...|.::.           ...||:.|....:..
Yeast    23 LGVDYGQQNIKAIVVSPQAPLELVLTPEAKRKEISGLSIKRLPGYGKDDPNGIERIYGSAVGSLA 87

  Fly    57 AMNPRNTVFDAKRLIGRKYDDPKIAE--DMKHWPFKVVSDGGKPKIGVEYKGESKRFAPEEISSM 119
            ...|:||:...|.|:|:..:|.....  ..:|...::||..   :..:.:..::..:..||:.:|
Yeast    88 TRFPQNTLLHLKPLLGKSLEDETTVTLYSKQHPGLEMVSTN---RSTIAFLVDNVEYPLEELVAM 149

  Fly   120 VLTKMKETAEAYLGES-------ITDAVITVPAYFNDSQRQATKDAGHI-AGLNVLRIINEPTAA 176
            .:.::...|.:.|.:.       :.....|:|.:|:..||:|..||..| .|:....:::|..:.
Yeast   150 NVQEIANRANSLLKDRDARTEDFVNKMSFTIPDFFDQHQRKALLDASSITTGIEETYLVSEGMSV 214

  Fly   177 ALAYGLDKNL--KGE-RNVLIFDLGGGTFDVSILTI------DEGSLFEVRSTAGDTHLGGEDF- 231
            |:.:.|.:..  .|| ::.:::|:|.|:...|:.:|      .:....|......:.||||..|
Yeast   215 AVNFVLKQRQFPPGEQQHYIVYDMGSGSIKASMFSILQPEDTTQPVTIEFEGYGYNPHLGGAKFT 279

  Fly   232 -------DNR-LVTHLA---DEFKRKYKKDLRSNPRALRRLRTAAERAKRTLSSSTEATIEIDAL 285
                   :|: |.||.|   ||        |.:||:||.::..|||:||..||:::||:|.|::|
Yeast   280 MDIGSLIENKFLETHPAIRTDE--------LHANPKALAKINQAAEKAKLILSANSEASINIESL 336

  Fly   286 FEGQDFYTKVSRARFEELCADLFRNTLQPVEKALNDA--KMDKG------QIHDIVLVGGSTRIP 342
            ....||.|.::|..|||..||    :|..:.|.:|||  |...|      :|:.::|.|||:|||
Yeast   337 INDIDFRTSITRQEFEEFIAD----SLLDIVKPINDAVTKQFGGYGTNLPEINGVILAGGSSRIP 397

  Fly   343 KVQSLLQDFFHGKNLNLSINPDEAVAYGAAVQAAILSGDQSGKIQDVLLVDVAPLSLGIETAG-G 406
            .||..|......:.:..::|.||:...|..::...||  .|.|.:.:.:||.:..:...:.:. .
Yeast   398 IVQDQLIKLVSEEKVLRNVNADESAVNGVVMRGIKLS--NSFKTKPLNVVDRSVNTYSFKLSNES 460

  Fly   407 VMTKLIERNCRIPCKQTKTFSTYADNQP-GVSIQVYEGER---AMTKDNNALGTFDLSGIPPAPR 467
            .:..:..|....|.| |...:...|:.| ..:|.::|..:   .:|.::.|:.....|  .....
Yeast   461 ELYDVFTRGSAYPNK-TSILTNTTDSIPNNFTIDLFENGKLFETITVNSGAIKNSYSS--DKCSS 522

  Fly   468 GVPQIEVTFDLDANGILNVS------AKEMSTGKAKNITIKNDKGRLS----QAEIDRM------ 516
            || ...:||||.::.:.::.      ..|...|.:|.  |||...||:    ..||.|:
Yeast   523 GV-AYNITFDLSSDRLFSIQEVNCICQSENDIGNSKQ--IKNKGSRLAFTSEDVEIKRLSPSERS 584

  Fly   517 -VNEAEKYADEDEKHR-QRITSRNALESYVFNVK------QAVEQAPAGKLDEADK--NSVLDKC 571
             ::|..|..|:.:|.| |...:.|.|||.:::.:      :.::..|..:::|..:  ...||
Yeast   585 RLHEHIKLLDKQDKERFQFQENLNVLESNLYDARNLLMDDEVMQNGPKSQVEELSEMVKVYLD-- 647

  Fly   572 NDTIRWL-DSNTTAEKEEFDHKLEEL 596
                 || |::...:.|:...::.|:
Yeast   648 -----WLEDASFDTDPEDIVSRIREI 668

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp70Aa	NP_731651.1	PTZ00009	2..642	CDD:240227	159/676 (24%)
LHS1	NP_012850.1	ASKHA_NBD_HSP70_HYOU1	21..431	CDD:466828	106/422 (25%)