Protein Alignment Hsp70Aa and hspa12b

DIOPT Version :10

• Sequence 1: NP_731651.1
• Gene: Hsp70Aa / 48581
• FlyBaseID: FBgn0013275
• Length: 642
• Species: Drosophila melanogaster
• Sequence 2: NP_001036151.1
• Gene: hspa12b / 735291
• ZFINID: ZDB-GENE-070226-1
• Length: 691
• Species: Danio rerio
• Alignment Length: 675
• Identity: 142/675 - (21%)
• Similarity: 238/675 - (35%)
• Gaps: 216/675 - (32%)

  Fly     4 IGIDLGTT---YSCVGVYQHGKVEIIANDQG------NRTTPSYVAFTDSERLIGDPAKNQVAMN 59
            :.||.|||   |:...:.....:.::...:|      |:.:|:.:..|...|.      :.....
Zfish    63 VAIDFGTTSSGYAFSFIEDPETIHMMRRWEGGDPGVANQKSPTCLLLTPDLRF------HSFGFA 121

  Fly    60 PRNTVFDAKRLIGRKYDDPKIAEDMKHW----PFKV----VSD----------GGKPKIGVEYKG 106
            .|::..|.         ||   |:.:||    .||:    .||          .|:....:|...
Zfish   122 ARDSYHDL---------DP---EEARHWLYFDKFKMKIHSTSDLTMETELESVSGRRVQAIEVFA 174

  Fly   107 ESKRFAPEEISSMVLTKMKETAEAYLGESITDAVITVPAYFNDSQRQATKDAGHIAGL------N 165
            .:.||..|.    .|.::|:.:.:.|..:....||||||.:....:|..::|.::|||      .
Zfish   175 HALRFFREH----ALKEVKDQSSSVLEGNEVRWVITVPAVWRQPAKQFMREAAYLAGLVPPDSPE 235

  Fly   166 VLRIINEPTAAAL------------------AYGLDKNLKGER---------------------- 190
            .|.|..||.||::                  ..|.|  :.|.|
Zfish   236 QLLIALEPEAASIYCRKLRLHQVTDLSQRPVTNGFD--IDGSRPFDSSFRQAREQLRRARHSRTF 298

  Fly   191 -----------------NVLIFDLGGGTFDVSILTID--EGSLFEV-RSTAGDTHLGGED--FDN 233
                             ..::.|.||||.|:::..|:  :|:|.|: :::.|.....|.|  |:.
Zfish   299 LVESGTGELWSEMQTGDRYIVADCGGGTVDLTVHQIEQPQGTLKELYKASGGPYGAVGVDLAFET 363

  Fly   234 RLV----THLADEFKRKYKKDLRSNPRALRRLRTAAERAKRTLSSSTEATIEIDALFEGQDFY-- 292
            .|.    |...|.||.|       .|.|...|..|.|..|||.:.....|:.|...|...|||
Zfish   364 MLCQIFGTDFIDSFKAK-------RPAAWVDLTIAFEARKRTAAPGRANTLNISLPFSFIDFYKQ 421

  Fly   293 ---------TKVSRARF------------EELCADLFRNTLQPVEKALNDAKMDKGQIHDI---V 333
                     .:.|...|            .|...:||:.|:..:.|.:.:. |.|.::..:   .
Zfish   422 HRGQSVETALRKSNMNFIKWSSQGMLRLSTEATNELFQPTINNIIKHIENV-MQKEEVKGVRFLF 485

  Fly   334 LVGGSTRIPKVQSLLQDFFHGKNLNLSINPDEAVAYGAAVQAAILSG-DQSGKIQDVLLVDVAPL 397
            ||||....|.:|..:|:.. |:|..:.|..|..:   ..::.|:|.| |.:     |:.|...||
Zfish   486 LVGGFAESPMLQRAIQNTL-GRNCRIIIPHDVGL---TILKGAVLFGLDPT-----VVRVRRCPL 541

  Fly   398 SLGIETAGGVMTKLIERNCRIPCKQTKTFSTYADNQPGVSIQVYEG--------ERAMTKDNN-A 453
            :.|:    ||:.:.:|                 ...|...:.:.:|        :|.::.|.: |
Zfish   542 TYGV----GVLNRFVE-----------------GRHPHDKLLIKDGREWCTDILDRFVSVDQSVA 585

  Fly   454 LGTFDLSGIPPAPRGVPQI----------EVTFDLDAN----GILNVSAKEMSTGKAKNITIKND 504
            ||........||..|..:|          ::|:..|..    |.:.:...|  :|:|...|..||
Zfish   586 LGEVVRRSYTPARMGQRKIIINIYCSDTDDITYITDPGVRKCGAITLDLLE--SGEASASTGDND 648

  Fly   505 KGRLSQAEIDRMVNEAEKYADEDEK 529
            ||...:.   |.:....::.|.:.|
Zfish   649 KGSAFER---REIRTTMQFGDTEIK 670

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp70Aa	NP_731651.1	PTZ00009	2..642	CDD:240227	142/675 (21%)
hspa12b	NP_001036151.1	ASKHA_NBD_HSP70_HSPA12B	61..528	CDD:466842	107/500 (21%)