Protein Alignment Hsp70Aa and Hspa12b

DIOPT Version :10

• Sequence 1: NP_731651.1
• Gene: Hsp70Aa / 48581
• FlyBaseID: FBgn0013275
• Length: 642
• Species: Drosophila melanogaster
• Sequence 2: NP_082582.1
• Gene: Hspa12b / 72630
• MGIID: 1919880
• Length: 685
• Species: Mus musculus
• Alignment Length: 648
• Identity: 142/648 - (21%)
• Similarity: 232/648 - (35%)
• Gaps: 200/648 - (30%)

  Fly    25 IIANDQGNRTTPSYVAF---TDSERLI-------GDP------AKNQVAMNPRNTVFDAKRLIGR 73
            ::|.|.|  ||.|..||   :|.|.:.       |||      ....:.:.|.. :|.:.....|
Mouse    62 VVAIDFG--TTSSGYAFSFASDPEAIHMMRKWEGGDPGVAHQKTPTCLLLTPEG-IFHSFGYTAR 123

  Fly    74 KYD---DPKIAEDMKHW-PFKV----VSD----------GGKPKIGVEYKGESKRFAPEEISSMV 120
            .|.   ||:.|.|..:: .||:    .:|          .||..:.:|....:.||..|.    .
Mouse   124 DYYHDLDPEEARDWLYFEKFKMKIHSATDLTLKTQLEAVNGKKMLALEVFAHALRFFKEH----A 184

  Fly   121 LTKMKETAEAYLGESITDAVITVPAYFNDSQRQATKDAGHIAGL------NVLRIINEPTAAAL- 178
            |.:::|.:|..|.:.....|:||||.:....:|..::|.::|||      ..|.|..||.||::
Mouse   185 LQELREQSECMLEKGAVRWVLTVPAIWKQPAKQFMREAAYLAGLVSREDAEKLLIALEPEAASVY 249

  Fly   179 ------------------------AYGLDKNLKGERNVL-------------------------- 193
                                    ...:|.:.:..|..|
Mouse   250 CRKLRLHQLMDLSSRTAGRGRLGERRSIDSSFRHAREQLRRSRHSRTFLVEAGVGELWAEMQEGD 314

  Fly   194 ---IFDLGGGTFDVSILTIDE--GSLFEV-RSTAGDTHLGGED--FDNRLVTHLADEFKRKYKKD 250
               :.|.||||.|:::..:::  |:|.|: :::.|.....|.|  |:..|.....::|..|:|
Mouse   315 RYMVADCGGGTVDLTVHQLEQPHGTLKELYKASGGPYGAVGVDLAFEQLLCRIFGEDFIAKFK-- 377

  Fly   251 LRSNPRALRRLRTAAERAKRTLSSSTEATIEIDALFEGQDFYTKVSRARFE-------------- 301
             |..|.|...|..|.|..|||........:.|...|...|||.|......|
Mouse   378 -RQRPAAWVDLTIAFEARKRTAGPHRAGALNISLPFSFIDFYRKQRGHNVETALRRSSVNLVKWS 441

  Fly   302 ---------ELCADLFRNT----LQPVEKALNDAKMDKGQIHDIVLVGGSTRIPKVQSLLQDFFH 353
                     |...:||:.|    :|.:|..|  ||.:...:..:.||||......:|..:|:...
Mouse   442 SQGMLRMSCEAMNELFQPTVSGIIQHIEMLL--AKPEVQGVKLLFLVGGFAESAVLQHAVQEALG 504

  Fly   354 GKNLNLSINPDEAVAYGAAVQAAILSGDQSGKIQDVLLVDVAPLSLGIETAGGVMT--------- 409
            .:.|.:.:..|..:   ..::.|:|.|...|    |:.|..:||:.|:    ||:.
Mouse   505 TRGLRVVVPHDVGL---TILKGAVLFGQAPG----VVRVRRSPLTYGV----GVLNRFVPGHHPP 558

  Fly   410 -KLIERNCRIPCKQTKTFS-----------------TYADNQPG---VSIQVY----EGERAMT- 448
             ||:.|:.|..|  |..|.                 :|...:||   |.|.:|    |..|.:|
Mouse   559 EKLLVRDGRRWC--TDVFERFVAAEQSVALGEEVRRSYCPARPGQRRVLINLYCCAAEDARFITD 621

  Fly   449 ---KDNNAL-------GTFDLSGIPPAPRGVPQIEVTFDLDANGILNVSAKEMSTGKAKNITI 501
               :...||       |..:.:|..|:.|.:.......|.:    :.|:|.::||.::....|
Mouse   622 PGVRKCGALSLELEPEGCPENTGTSPSRREIRAAMQFGDTE----IKVTAVDVSTNRSVRAAI 680

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp70Aa	NP_731651.1	PTZ00009	2..642	CDD:240227	142/648 (22%)
Hspa12b	NP_082582.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..50
		ASKHA_ATPase-like	61..528	CDD:483947	105/480 (22%)