Protein Alignment Hsp70Aa and Hspa4

DIOPT Version :10

• Sequence 1: NP_731651.1
• Gene: Hsp70Aa / 48581
• FlyBaseID: FBgn0013275
• Length: 642
• Species: Drosophila melanogaster
• Sequence 2: NP_705893.1
• Gene: Hspa4 / 266759
• RGDID: 628878
• Length: 840
• Species: Rattus norvegicus
• Alignment Length: 830
• Identity: 223/830 - (26%)
• Similarity: 359/830 - (43%)
• Gaps: 208/830 - (25%)

  Fly     1 MPAIGIDLGTTYSCVGVYQHGKVEIIANDQGNRTTPSYVAFTDSERLIGDPAKNQVAMNPRNTVF 65
            |..:|||||.....|.|.:.|.:|.|||:..:|.||:.|:|....|.:|..||:||..|.:|||.
  Rat     1 MSVVGIDLGFQSCYVAVARAGGIETIANEYSDRCTPACVSFGPKNRSVGAAAKSQVISNAKNTVQ 65

  Fly    66 DAKRLIGRKYDDPKIAEDMKHWPFKVVS-DGGKPKIGVEYKGESKRFAPEEISSMVLTKMKETAE 129
            ..||..||.:.||.:..:..:..:.:|. ..|...|.|.|..|.:.|..|::::|:|:|:|||||
  Rat    66 GFKRFHGRAFSDPFVEAEKSNLAYDIVQLPTGLTGIKVTYMEEERNFTTEQVTAMLLSKLKETAE 130

  Fly   130 AYLGESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGLDKN-----LKGE 189
            :.|.:.:.|.|::||:::.|::|::..||..|||||.||::||.||.|||||:.|.     .:..
  Rat   131 SVLKKPVVDCVVSVPSFYTDAERRSVMDATQIAGLNCLRLMNETTAVALAYGIYKQDLPALEEKP 195

  Fly   190 RNVLIFDLGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVTHLADEFKRKYKKDLRSN 254
            |||:..|:|...:.||:...:.|.| :|.:||.||.|||..||..||.|..:||.:|||.|::|.
  Rat   196 RNVVFVDMGHSAYQVSVCAFNRGKL-KVLATAFDTTLGGRKFDEVLVNHFCEEFGKKYKLDIKSK 259

  Fly   255 PRALRRLRTAAERAKRTLS-SSTEATIEIDALFEGQDFYTKVSRARFEELCADLFRNTLQPVEKA 318
            .|||.||....|:.|:.:| ::::..:.|:......|....::|.:|.|:|.||......|:...
  Rat   260 VRALLRLSQECEKLKKLMSANASDLPLSIECFMNDIDVSGTMNRGKFLEMCDDLLARVEPPLRSI 324

  Fly   319 LNDAKMDKGQIHDIVLVGGSTRIPKVQSLLQDFFHGKNLNLSINPDEAVAYGAAVQAAILSGDQS 383
            |:.:|:.|..|:.:.:|||:||||.|:..:..|| ||.|:.::|.||||..|.|:|.||||  .:
  Rat   325 LDQSKLKKEDIYAVEIVGGATRIPAVKEKISKFF-GKELSTTLNADEAVTRGCALQCAILS--PA 386

  Fly   384 GKIQDVLLVDVAPLSLGIE-----TAGGVMTKLIERNCRIPCKQTKTFSTYADNQPGVSIQVYEG 443
            .|:::..:.||.|..:.:.     ..|....::..:|...|..:..||..   .:|......|..
  Rat   387 FKVREFSITDVVPYPISLRWNSPAEEGSSDCEVFPKNHAAPFSKVLTFYR---KEPFTLEAYYSS 448

  Fly   444 ERAMTKDNNALGTFDLSGIPPAPRG-VPQIEVTFDLDANGILNVS-------------------- 487
            .:.:...:.|:..|.:..:.|...| ..:::|...::.:||.:||
  Rat   449 PQDLPYPDPAIAQFSVQKVTPQSDGSSSKVKVKVRVNVHGIFSVSSAALVEVHKSEESEEPMETD 513

  Fly   488 --------------------------------AKEMSTGKAKNITIKND------KGRLSQAEID 514
                                            ::||.|.:|.:...|.|      |.::..:.:|
  Rat   514 QNAKEEEKMQVDQEEPHTEEQQPQTPAENKAESEEMETSQAGSKDKKMDQPPQAKKAKVKTSTVD 578

  Fly   515 RMV------------------NEAEKYADEDEKHRQRITSRNALESYVFNVK------------- 548
            ..:                  ||. |...:|:..::|..::||:|.||:.::
  Rat   579 LPIESQLLWQLDREMLGLYTENEG-KMIMQDKLEKERNDAKNAVEEYVYEMRDKLSGEYEKFVSE 642

  Fly   549 -----------------------------------------------QAVEQAP-----AGK--- 558
                                                           |..|:.|     .||
  Rat   643 DDRNNFTLKLEDTENWLYEDGEDQPKQVYVDKLAELRTLGQPIKTRFQESEERPKLFEELGKQIQ 707

  Fly   559 ------------------LDEADKNSVLDKCNDTIRWLDS--------NTTAE----KEEFDHKL 593
                              ||.||...|....|:.:.|::|        :.||:    .:|.:.|:
  Rat   708 QYMKVISSFKNKEDQYEHLDAADMTKVEKSTNEAMEWMNSKLNLQNKQSLTADPVVKTKEIEAKI 772

  Fly   594 EELTRHCSPIMTK------------MHQQGAGAGAGGPGANCGQQAGGFG 631
            :|||..||||::|            .|.:..|. ..|.|.|.|.||...|
  Rat   773 KELTNICSPIISKPKPKVEPPKEEPKHAEQNGP-VDGQGDNPGTQAAEHG 821

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp70Aa	NP_731651.1	PTZ00009	2..642	CDD:240227	222/829 (27%)
Hspa4	NP_705893.1	ASKHA_NBD_HSP70_HSPA4	2..382	CDD:466843	146/381 (38%)
		PTZ00121	<499..743	CDD:173412	29/244 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	500..575		7/74 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	781..840		12/42 (29%)