Protein Alignment Hsp70Aa and Hspa4

DIOPT Version :10

• Sequence 1: NP_731651.1
• Gene: Hsp70Aa / 48581
• FlyBaseID: FBgn0013275
• Length: 642
• Species: Drosophila melanogaster
• Sequence 2: NP_032326.3
• Gene: Hspa4 / 15525
• MGIID: 1342292
• Length: 842
• Species: Mus musculus
• Alignment Length: 831
• Identity: 223/831 - (26%)
• Similarity: 357/831 - (42%)
• Gaps: 208/831 - (25%)

  Fly     1 MPAIGIDLGTTYSCVGVYQHGKVEIIANDQGNRTTPSYVAFTDSERLIGDPAKNQVAMNPRNTVF 65
            |..:|||||.....|.|.:.|.:|.|||:..:|.||:.|:|....|.||..||:||..|.:|||.
Mouse     1 MSVVGIDLGFQSCYVAVARAGGIETIANEYSDRCTPACVSFGPKNRSIGAAAKSQVISNAKNTVQ 65

  Fly    66 DAKRLIGRKYDDPKIAEDMKHWPFKVVS-DGGKPKIGVEYKGESKRFAPEEISSMVLTKMKETAE 129
            ..||..||.:.||.:..:..:..:.:|. ..|...|.|.|..|.:.|..|::::|:|:|:|||||
Mouse    66 GFKRFHGRAFSDPFVEAEKSNLAYDIVQLPTGLTGIKVTYMEEERNFTTEQVTAMLLSKLKETAE 130

  Fly   130 AYLGESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGLDKN-----LKGE 189
            :.|.:.:.|.|::||:::.|::|::..||..|||||.||::||.||.|||||:.|.     .:..
Mouse   131 SVLKKPVVDCVVSVPSFYTDAERRSVMDATQIAGLNCLRLMNETTAVALAYGIYKQDLPALEEKP 195

  Fly   190 RNVLIFDLGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVTHLADEFKRKYKKDLRSN 254
            |||:..|:|...:.||:...::|.| :|.:||.||.|||..||..||.|..:||.:|||.|::|.
Mouse   196 RNVVFVDMGHSAYQVSVCAFNKGKL-KVLATAFDTTLGGRKFDEVLVNHFCEEFGKKYKLDIKSK 259

  Fly   255 PRALRRLRTAAERAKRTLS-SSTEATIEIDALFEGQDFYTKVSRARFEELCADLFRNTLQPVEKA 318
            .|||.||....|:.|:.:| ::::..:.|:......|....::|.:|.|:|.||......|:...
Mouse   260 IRALLRLSQECEKLKKLMSANASDLPLSIECFMNDIDVSGTMNRGKFLEMCDDLLARVEPPLRSV 324

  Fly   319 LNDAKMDKGQIHDIVLVGGSTRIPKVQSLLQDFFHGKNLNLSINPDEAVAYGAAVQAAILSGDQS 383
            |..:|:.|..|:.:.:|||:||||.|:..:..|| ||.|:.::|.||||..|.|:|.||||  .:
Mouse   325 LEQSKLKKEDIYAVEIVGGATRIPAVKEKISKFF-GKELSTTLNADEAVTRGCALQCAILS--PA 386

  Fly   384 GKIQDVLLVDVAPLSLGIETAGGVMTKLIERNCRI-PCKQTKTFS---TYADNQPGVSIQVYEGE 444
            .|:::..:.||.|..:.:.........|  .:|.: |......||   |:...:|......|...
Mouse   387 FKVREFSITDVVPYPISLRWNSPAEEGL--SDCEVFPKNHAAPFSKVLTFYRKEPFTLEAYYSSP 449

  Fly   445 RAMTKDNNALGTFDLSGIPPAPRG-VPQIEVTFDLDANGILNVS--------------------- 487
            :.:...:.|:..|.:..:.|...| ..:::|...::.:||.:||
Mouse   450 QDLPYPDPAIAQFSVQKVTPQSDGSSSKVKVKVRVNVHGIFSVSSAALVEVHKSEESEEPMETDQ 514

  Fly   488 ---------------------------------AKEMSTGKAKNITIKND------KGRLSQAEI 513
                                             ::||.|.:|.:...|.|      |.::..:.:
Mouse   515 NAKEEEKMQVDQEEPHTEEQQQQPQTPAENKAESEEMETSQAGSKDKKTDQPPQAKKAKVKTSTV 579

  Fly   514 DRMV------------------NEAEKYADEDEKHRQRITSRNALESYVFNVK------------ 548
            |..:                  ||. |...:|:..::|..::||:|.||:.::
Mouse   580 DLPIESQLLWQLDREMLGLYTENEG-KMIMQDKLEKERNDAKNAVEEYVYEMRDKLSGEYEKFVS 643

  Fly   549 ------------------------------------------------QAVEQAP-----AGK-- 558
                                                            |..|:.|     .||
Mouse   644 EDDRNTFTLKLEDTENWLYEDGEDQPKQVYVDKLAELKSLGQPIKTRFQESEERPKLFEELGKQI 708

  Fly   559 -------------------LDEADKNSVLDKCNDTIRWLDS------------NTTAEKEEFDHK 592
                               ||.||...|....|:.:.|::|            :...:.:|.:.|
Mouse   709 QQYMKVISSFKNKEDQYEHLDAADVTKVEKSTNEAMEWMNSKLNLQNKQSLTVDPVVKTKEIEAK 773

  Fly   593 LEELTRHCSPIMTK------------MHQQGAGAGAGGPGANCGQQAGGFG 631
            ::|||..||||::|            .|.:..|. ..|.|.|.|.||...|
Mouse   774 IKELTSICSPIISKPKPKVEPPKEEPKHAEQNGP-VDGQGDNPGSQAAEHG 823

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp70Aa	NP_731651.1	PTZ00009	2..642	CDD:240227	222/830 (27%)
Hspa4	NP_032326.3	ASKHA_NBD_HSP70_HSPA4	2..382	CDD:466843	147/381 (39%)
		PTZ00121	<499..745	CDD:173412	29/246 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	500..577		7/76 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	784..842		11/41 (27%)