Protein Alignment Hsp70Aa and Hsph1

DIOPT Version :10

• Sequence 1: NP_731651.1
• Gene: Hsp70Aa / 48581
• FlyBaseID: FBgn0013275
• Length: 642
• Species: Drosophila melanogaster
• Sequence 2: XP_006504979.1
• Gene: Hsph1 / 15505
• MGIID: 105053
• Length: 877
• Species: Mus musculus
• Alignment Length: 684
• Identity: 201/684 - (29%)
• Similarity: 324/684 - (47%)
• Gaps: 122/684 - (17%)

  Fly    37 SYVAFTDSERLIGDPAKNQVAMNPRNTVFDAKRLIGRKYDDPKIAEDMKHWPFKVV--SDGGKPK 99
            |.::|....|.||..||||...:..|||...||..||.::||.|.::.::..:.:|  .:||
Mouse    56 SVISFGSKNRTIGVAAKNQQITHANNTVSSFKRFHGRAFNDPFIQKEKENLSYDLVPMKNGG--- 117

  Fly   100 IGVE--YKGESKRFAPEEISSMVLTKMKETAEAYLGESITDAVITVPAYFNDSQRQATKDAGHIA 162
            :|::  |..|...|:.|:|::|:|||:|||||..|.:.:||.||:||::|.|::|::..||..|.
Mouse   118 VGIKVMYMDEEHFFSVEQITAMLLTKLKETAENNLKKPVTDCVISVPSFFTDAERRSVLDAAQIV 182

  Fly   163 GLNVLRIINEPTAAALAYGLDK----NLKGERNVLIF-DLGGGTFDVSILTIDEGSLFEVRSTAG 222
            |||.||::|:.||.||.||:.|    |.:.:..|::| |:|..:|.||....::|.| :|..||.
Mouse   183 GLNCLRLMNDMTAVALNYGIYKQDLPNAEEKPRVVVFVDMGHSSFQVSACAFNKGKL-KVLGTAF 246

  Fly   223 DTHLGGEDFDNRLVTHLADEFKRKYKKDLRSNPRALRRLRTAAERAKRTLSS-STEATIEIDALF 286
            |..|||::||.:||.|...|||.|||.|.:|..|||.||....|:.|:.:|| ||:..:.|:...
Mouse   247 DPFLGGKNFDEKLVEHFCAEFKTKYKLDAKSKIRALLRLHQECEKLKKLMSSNSTDLPLNIECFM 311

  Fly   287 EGQDFYTKVSRARFEELCADLFRNTLQPVEKALNDAKMDKGQIHDIVLVGGSTRIPKVQSLLQDF 351
            ..:|...|::|::||||||:|.:....|:...:...::....:..|.:|||:||||.|:..:..|
Mouse   312 NDKDVSGKMNRSQFEELCAELLQKIEVPLHSLMAQTQLKAEDVSAIEIVGGATRIPAVKERIAKF 376

  Fly   352 FHGKNLNLSINPDEAVAYGAAVQAAILSGDQSGKIQDVLLVDVAPLSLGI-------ETAGGVMT 409
            | ||:::.::|.|||||.|.|:|.||||  .:.|:::..:.|..|..:.:       ||.|  :.
Mouse   377 F-GKDVSTTLNADEAVARGCALQCAILS--PAFKVREFSVTDAVPFPISLVWNHDSEETEG--VH 436

  Fly   410 KLIERNCRIPCKQTKTF---------STYADNQ--------------PGVSIQVYEGERAMTK-- 449
            ::..||...|..:..||         :.|:|.|              ..||.| .:||::..|
Mouse   437 EVFSRNHAAPFSKVLTFLRRGPFELEAFYSDPQGVPYPEAKIGRFVVQNVSAQ-KDGEKSRVKVK 500

  Fly   450 -----------------------------------------------------DNNALGT----- 456
                                                                 ||:..||
Mouse   501 VRVNTHGIFTISTASMVEKVPTEEEDGSSLEADMECPNQRPTESSDVDKNIQQDNSEAGTQPQVQ 565

  Fly   457 ---FDLSGIPPAPRGVPQIEVTFDLD-ANGILNVSAKEMSTGKAKNITIK-----NDKGRLSQAE 512
               ...|..||:|....:...|.|.| ||........|....|.|.:.::     |...:|.:..
Mouse   566 TDGQQTSQSPPSPELTSEESKTPDADKANEKKVDQPPEAKKPKIKVVNVELPVEANLVWQLGRDL 630

  Fly   513 IDRMVNEAEKYADEDEKHRQRITSRNALESYVFNVKQAVEQAPAGK-LDEADKNSVLDKCNDTIR 576
            ::..:....|...:|:..::|..::||:|..|:..:..: ..|..| :.|.:....|....:|..
Mouse   631 LNMYIETEGKMIMQDKLEKERNDAKNAVEECVYEFRDKL-CGPYEKFICEQEHEKFLRLLTETED 694

  Fly   577 WL-DSNTTAEKEEFDHKLEELTRHCSPIMTKMHQ 609
            || :......|:.:..|||||.:..:|:..:..:
Mouse   695 WLYEEGEDQAKQAYIDKLEELMKMGTPVKVRFQE 728

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp70Aa	NP_731651.1	PTZ00009	2..642	CDD:240227	201/684 (29%)
Hsph1	XP_006504979.1	ASKHA_ATPase-like	56..400	CDD:483947	138/348 (40%)